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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by adamie on November 14, 2001, at 22:03:06
hi. JohnX2, earlier you have said that Zyprexa may interact with Moclobemide (I think it deffinetly does). I stopped zyprexa yesterday. How long would it take for the zyprexa to be gone enough from my system in order for me to try Moclobemide (or any med that may have interacted with the zyprexa).
Posted by adamie on November 14, 2001, at 23:08:52
In reply to JohnX2, or anyone regarding stopping zyprexa, posted by adamie on November 14, 2001, at 22:03:06
since moclobemide raises the amount of zyprexa in my system... would taking moclobemide prevent it from leaving my system or would it all go away regardless since I am not taking zyprexa anymore?> hi. JohnX2, earlier you have said that Zyprexa may interact with Moclobemide (I think it deffinetly does). I stopped zyprexa yesterday. How long would it take for the zyprexa to be gone enough from my system in order for me to try Moclobemide (or any med that may have interacted with the zyprexa).
Posted by jay on November 15, 2001, at 3:41:44
In reply to also..., posted by adamie on November 14, 2001, at 23:08:52
>
> since moclobemide raises the amount of zyprexa in my system... would taking moclobemide prevent it from leaving my system or would it all go away regardless since I am not taking zyprexa anymore?
>
> > hi. JohnX2, earlier you have said that Zyprexa may interact with Moclobemide (I think it deffinetly does). I stopped zyprexa yesterday. How long would it take for the zyprexa to be goneenough from my system in order for me to try Moclobemide (or any med that may have interacted with the zyprexa).
Not quite sure about the Zyprexa....I would say a few days. The moclobemide has a very short half-life, but just to be safe, go with a day. This is all IMHO...you should ask your doc.
Jay
Posted by JohnX2 on November 16, 2001, at 14:41:00
In reply to Re: also... » adamie, posted by jay on November 15, 2001, at 3:41:44
I agree ask your pdoc.
Generally I would expect zyprexa to clear
out most of the way in about 4+ days, but
with the manerix in your body it may take
longer. Also, I don't recommend quiting
zyprexa cold turkey. I suggest tapering
down at least over 1 week.-john
> >
> > since moclobemide raises the amount of zyprexa in my system... would taking moclobemide prevent it from leaving my system or would it all go away regardless since I am not taking zyprexa anymore?
> >
> > > hi. JohnX2, earlier you have said that Zyprexa may interact with Moclobemide (I think it deffinetly does). I stopped zyprexa yesterday. How long would it take for the zyprexa to be gone
>
> enough from my system in order for me to try Moclobemide (or any med that may have interacted with the zyprexa).
>
> Not quite sure about the Zyprexa....I would say a few days. The moclobemide has a very short half-life, but just to be safe, go with a day. This is all IMHO...you should ask your doc.
>
> Jay
Posted by adamie on November 16, 2001, at 15:44:15
In reply to Re: also..., posted by JohnX2 on November 16, 2001, at 14:41:00
I stopped zyprexa 3-4 days ago and I have had no withdrawl issues. i will be seeing a new pdoc on Wednesday. Maybe I will try ECT again. I have been feeling completely horrible but today I am slightly better. I feel that is from getting up from bed earlier. I will continue to sleep less. Yesterday I was not feeling too horrible when I first woke up at 11am. Then I went to sleep again and woke up at 2pm... I was feeling quite worse.
> I agree ask your pdoc.
> Generally I would expect zyprexa to clear
> out most of the way in about 4+ days, but
> with the manerix in your body it may take
> longer. Also, I don't recommend quiting
> zyprexa cold turkey. I suggest tapering
> down at least over 1 week.
>
> -john
>
>
>
> > >
> > > since moclobemide raises the amount of zyprexa in my system... would taking moclobemide prevent it from leaving my system or would it all go away regardless since I am not taking zyprexa anymore?
> > >
> > > > hi. JohnX2, earlier you have said that Zyprexa may interact with Moclobemide (I think it deffinetly does). I stopped zyprexa yesterday. How long would it take for the zyprexa to be gone
> >
> > enough from my system in order for me to try Moclobemide (or any med that may have interacted with the zyprexa).
> >
> > Not quite sure about the Zyprexa....I would say a few days. The moclobemide has a very short half-life, but just to be safe, go with a day. This is all IMHO...you should ask your doc.
> >
> > Jay
Posted by JohnX2 on November 17, 2001, at 2:16:53
In reply to Re: also... » JohnX2, posted by adamie on November 16, 2001, at 15:44:15
I really hope you find relief to your problems.
I empathize to the amount of turbulence you
have experienced.There are a few routes you haven't tried that
I would give a go:
- Anticonvulsant - > Lamictal for starters
can also try Trileptal,Tegetrol,Depakote,etc.
- MOAB Inhibitor - > Parnate or Selegiline.This is my personal opinion and experience
so take it with a grain of salt. If you take
Lamictal, and dose it *really* slowly over
1.5-2 months, you can reach the therapeutic
range and it may stabilize your situation
substantially. With slow dosing, the likelihood
of it making things worse is very very low
in my opinion. Very few people get worse on
Lamictal and a lot of people get relief from
major depression. You may need an adjunctive
anti-depressant to rid any risidual anhedonia,
but if you really are some form of bipolar then
you really need to be on a med that stabilizes
electrical conductance (i.e. an anti-convulsant).
ECT is just a quick method to increase conductance
in the brain, how it cures depression is a bit
of a mystery. The anti-convulsants generally
stabilize glutamate (the primary stimulatory
chemical) and gaba (the primary dampening chemical).
Think about it this way, what if the accelerator
on your car didn't have a feed-back control mechanism
in place? It would go haywire, you would continue
to accelerate quickly until you exhausted your
engine. This is what happens in bipolar. We need
to have "referees" standing by keeping these
electrical signals in "check". Without this it
is difficult to "stabilize" the situation. You
seem to be going through so many ups-n-downs
I really think a mood stabilizer (generally
an anti-epileptic=anti-convulsant) would be in
order if you haven't tried one. This is standard
procedure. Again, this is just my opinion.
I tried near every anti-depressant and alternative
form of anti-depressant on planet earth before
finding out that the mood-stabilizers were the
right solution. I think it would be prudent
to test a mood stablizer before trying more and
more and more anti-depressants.Please feel better. I really want to see things
stabilize for you it really sounds like you are
going through hell..I'm really sorry.regards,
john
>
> I stopped zyprexa 3-4 days ago and I have had no withdrawl issues. i will be seeing a new pdoc on Wednesday. Maybe I will try ECT again. I have been feeling completely horrible but today I am slightly better. I feel that is from getting up from bed earlier. I will continue to sleep less. Yesterday I was not feeling too horrible when I first woke up at 11am. Then I went to sleep again and woke up at 2pm... I was feeling quite worse.
>
> > I agree ask your pdoc.
> > Generally I would expect zyprexa to clear
> > out most of the way in about 4+ days, but
> > with the manerix in your body it may take
> > longer. Also, I don't recommend quiting
> > zyprexa cold turkey. I suggest tapering
> > down at least over 1 week.
> >
> > -john
> >
> >
> >
> > > >
> > > > since moclobemide raises the amount of zyprexa in my system... would taking moclobemide prevent it from leaving my system or would it all go away regardless since I am not taking zyprexa anymore?
> > > >
> > > > > hi. JohnX2, earlier you have said that Zyprexa may interact with Moclobemide (I think it deffinetly does). I stopped zyprexa yesterday. How long would it take for the zyprexa to be gone
> > >
> > > enough from my system in order for me to try Moclobemide (or any med that may have interacted with the zyprexa).
> > >
> > > Not quite sure about the Zyprexa....I would say a few days. The moclobemide has a very short half-life, but just to be safe, go with a day. This is all IMHO...you should ask your doc.
> > >
> > > Jay
This is the end of the thread.
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