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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by ben on November 5, 2001, at 10:21:16
Hi
My doc wants me to change to moclobemide (AURORIX) after trying several AD (Celexa, Zoloft, Surmontil, Efexor, Remeron, Edronax...and finally Paxil). Paxil worked best for me (30 mg/d) but I gained weight (hungry), allways feel tired and lost my sex drive...besides bruxism. This makes me frustrated so I feel sad after 2 month of being not depressed (concerning mood).
Any good results with this drug ? I hope to hear from really good responses.ben
Posted by tina on November 5, 2001, at 22:52:29
In reply to Moclobemide (AURORIX) any good results ?, posted by ben on November 5, 2001, at 10:21:16
Hey Ben
This was a miracle pill for me. No weight gain, no drowsiness, no side effects whatsoever. Just remember, your mileage may vary so the only way to know for sure is to give it a try.
Paxil and other SSRI's didn't agree with me at all.
Good luck
Tina> Hi
>
> My doc wants me to change to moclobemide (AURORIX) after trying several AD (Celexa, Zoloft, Surmontil, Efexor, Remeron, Edronax...and finally Paxil). Paxil worked best for me (30 mg/d) but I gained weight (hungry), allways feel tired and lost my sex drive...besides bruxism. This makes me frustrated so I feel sad after 2 month of being not depressed (concerning mood).
> Any good results with this drug ? I hope to hear from really good responses.
>
> ben
Posted by Sigolène on November 7, 2001, at 13:19:02
In reply to Moclobemide (AURORIX) any good results ?, posted by ben on November 5, 2001, at 10:21:16
Aurorix was not effective for me and worsen my depression.
Sigolène
Posted by SLS on November 7, 2001, at 16:27:17
In reply to Re: Moclobemide (AURORIX) any good results ?, posted by Sigolène on November 7, 2001, at 13:19:02
> Aurorix was not effective for me and worsen my depression.
>
> Sigolène
Hi Sigolène.Je ne vous ai pas vu pour longtemps. Comment allez-vous?
Moclobemide made my depression much, much worse. It was the worst I have ever felt. I spent the whole day curled up into a ball (fetal position), moaning and wimpering. It felt truly painful.
- Scott
Posted by ben on November 7, 2001, at 23:38:43
In reply to Re: Moclobemide (AURORIX) any good results ? » Sigolène, posted by SLS on November 7, 2001, at 16:27:17
@ Scott and Sigolene:
I wanted to hear from good results but you are scarey me ! So please do not post such bad reactions if it doesnt contribue to faithfullness.
Posted by petters on November 8, 2001, at 0:33:26
In reply to Re: Moclobemide (AURORIX) any good results ? » Sigolène, posted by SLS on November 7, 2001, at 16:27:17
> > Aurorix was not effective for me and worsen my depression.
> >
> > Sigolène
>
>
> Hi Sigolène.
>
> Je ne vous ai pas vu pour longtemps. Comment allez-vous?
>
> Moclobemide made my depression much, much worse. It was the worst I have ever felt. I spent the whole day curled up into a ball (fetal position), moaning and wimpering. It felt truly painful.
>
>
> - Scott
Hi Scott...I completely aggree. Moclobemide is not an potanial drug. In my country its has get the indication for social anxiety. We have had it here for 11 yeas.
But I know one famous pdoc, that add an small amount Citalopram 10- 20 mg, and this combo enhace the effect very promt. I know the risk of combo MAOI, with ssri, but in this case it seems to work, without serotonergic syndrom as Nardil or Parnate would do. And in case if one had serotonergic syndrom sign, one should have Pericatin at home, just to be sure.
By the way Scott...You mention that Valoprate was consider to be better than Litium in bipolar 2. I also had that opinion. But a proffessor certenly preffered Litium in this case, due to its more potent antidepressant effect.
By the way Scott....A couple of non farmacological tips, witch is easy to forgett.
30 min of regular exercice......every day
Make sure to be out in daylight 45 mg/day
What about 10mg omega 3 fett acid. Have you tried it. I haven´t.
I know you want to have a trial on memantadine. It don´t think it take so long time to we get it in my country.
Clomipramine infusion (or injection) + Litium + Tryptofan. An old but great combo in refractary cases, that some clinical use in my country, with great succes.
And as I wrote lastely. Lamotrigine + Topipramate seems also be greate in bipolar depression. Ivan Goldberg wrote about this.
Sincerly
Petters
Posted by SLS on November 8, 2001, at 7:46:09
In reply to Re: Moclobemide - GOOD results, posted by ben on November 7, 2001, at 23:38:43
> @ Scott and Sigolene:
>
> I wanted to hear from good results but you are scarey me ! So please do not post such bad reactions if it doesnt contribue to faithfullness.
Hi Ben.I guess I should have added a statement referring to the individual variability in how one reacts to these psychotropic medications (YMMV). Just about every antidepressant can cause depression to get worse for some people. I can't think of a single exception, so it would be difficult to justify excluding any one drug from consideration based on this potential adverse reaction. However, some drugs seem to do this more frequently than others. In my opinion, reboxetine is one such drug. As I see it, moclobemide helps much more often than it hurts. It also seems to help less often than it does help. Moclobemide has greatly lost its popularity and market share worldwide.
On the flip-side, just about every antidepressant is a miracle drug for some people. Again, I can't think of a single exception. Perhaps this will be true of moclobemide for you. I hope so.
Most people who do respond to moclobemide do so quickly, usually within the first week. However, it is the personality of this drug to lose effectiveness with time, often gradually. People tend to need dosage increases along the way, which often succeed in recapturing the antidepressant response. Some people do reach the upper limit of the dosage range, generally 1200 mg, without experiencing a stable antidepressant response.
These are the facts as I have come to know them. My sources include peer-reviewed medical journals, conversations with many researchers and clinicians, personal experience, and the descriptions by others of their personal experiences. I think it is important that people post this type of information (which may or may not be accurate) on Psycho-Babble. You may not find it anywhere else. I believe it is crucial that this board act as a clearinghouse of personal experiences, good and bad. In my opinion, this is the true value of this newsgroup.
A few things to remember:
1. Most people are here because they were not fortunate enough to fill their doctor's first prescription and live happily ever after.
2. That the biologies of these people are probably somewhat different from those who respond easily to treatment might yield a trend towards unusual negative reactions to medication.
3. People who have not had a negative reaction to a specific drug are less likely to post about their non-experiences. For every person who describes a negative reaction to a drug, there are probably many more who haven't.
4. People can be wrong about the information and opinions they post. Even doctors and Ph.D.s are capable of being wrong, so an appropriate amount of caution must be maintained when evaluating the validity of statements made by people who are not.
Without knowing the specifics of you situation, I cannot think of any reason for you not to try moclobemide. Moclobemide can and does work, and it usually produces very few, if any, side effects.
Good luck.
- Scott
Posted by ben on November 8, 2001, at 13:06:11
In reply to Re: Moclobemide - GOOD results » ben, posted by SLS on November 8, 2001, at 7:46:09
> > @ Scott and Sigolene:
> >
> > I wanted to hear from good results but you are scarey me ! So please do not post such bad reactions if it doesnt contribue to faithfullness.
>
>
> Hi Ben.
>
> I guess I should have added a statement referring to the individual variability in how one reacts to these psychotropic medications (YMMV). Just about every antidepressant can cause depression to get worse for some people. I can't think of a single exception, so it would be difficult to justify excluding any one drug from consideration based on this potential adverse reaction. However, some drugs seem to do this more frequently than others. In my opinion, reboxetine is one such drug. As I see it, moclobemide helps much more often than it hurts. It also seems to help less often than it does help. Moclobemide has greatly lost its popularity and market share worldwide.
>
> On the flip-side, just about every antidepressant is a miracle drug for some people. Again, I can't think of a single exception. Perhaps this will be true of moclobemide for you. I hope so.
>
> Most people who do respond to moclobemide do so quickly, usually within the first week. However, it is the personality of this drug to lose effectiveness with time, often gradually. People tend to need dosage increases along the way, which often succeed in recapturing the antidepressant response. Some people do reach the upper limit of the dosage range, generally 1200 mg, without experiencing a stable antidepressant response.
>
> These are the facts as I have come to know them. My sources include peer-reviewed medical journals, conversations with many researchers and clinicians, personal experience, and the descriptions by others of their personal experiences. I think it is important that people post this type of information (which may or may not be accurate) on Psycho-Babble. You may not find it anywhere else. I believe it is crucial that this board act as a clearinghouse of personal experiences, good and bad. In my opinion, this is the true value of this newsgroup.
>
> A few things to remember:
>
> 1. Most people are here because they were not fortunate enough to fill their doctor's first prescription and live happily ever after.Thats right.
> 2. That the biologies of these people are probably somewhat different from those who respond easily to treatment might yield a trend towards unusual negative reactions to medication.
Who knows ?!
> 3. People who have not had a negative reaction to a specific drug are less likely to post about their non-experiences. For every person who describes a negative reaction to a drug, there are probably many more who haven't.
What do you mean with negative reaction ?
Undesired effects are allways negative. Over 90 percent (treated with ADs) are expieriencing at least one undesired effect (including weight gain in long term use).> 4. People can be wrong about the information and opinions they post. Even doctors and Ph.D.s are capable of being wrong, so an appropriate amount of caution must be maintained when evaluating the validity of statements made by people who are not.
>
Should be clear to everyone. Dont forget the psychological effects of postings ! Not only "facts" are helpfull. If somebody is looking for people with good expierences for a drug it could be better not to post bad reactions.
Posting of bad reactions could be good to share the pain with others.> Without knowing the specifics of you situation, I cannot think of any reason for you not to try moclobemide. Moclobemide can and does work, and it usually produces very few, if any, side effects.
>
> Good luck.
>
Best regards and apologize me if you felt attacked.Ben
Posted by dave_fox on November 8, 2001, at 15:30:54
In reply to Moclobemide (AURORIX) any good results ?, posted by ben on November 5, 2001, at 10:21:16
A few people seem to get on badly with Moclobemide but to me it has been wonderful.
It gives me ALERTNESS without AGITATION. (I am stealing a line of advertising copy for som eothe rmed there.) It is almost a cognitive enhancer for me.I get bad side effects after about 450 mg so I have to keep the dose on the low side. However the big problem for me was POOP OUT after only a few months.
If anyone can advise on how to reduce poop out then please let me know. I am going to restart it and I expect it will be ok provided I keep up the "pressure" by increasing the dose as I get used to a given level.
Is there anything I can add to Moclobemide to reduce or overcome poop out?
Thanks!
Dave
Posted by Chocoholic on November 8, 2001, at 18:42:10
In reply to Moclobemide (AURORIX) any good results ?, posted by ben on November 5, 2001, at 10:21:16
>Ben--
I took moclobemide for 3 years, which gave me a good partial response. I only quit taking it to try some new combos of meds. I also wonder if the efficacy was impacted by all of the soy and chocolate I ate!Chocoholic
>
> My doc wants me to change to moclobemide (AURORIX) after trying several AD (Celexa, Zoloft, Surmontil, Efexor, Remeron, Edronax...and finally Paxil). Paxil worked best for me (30 mg/d) but I gained weight (hungry), allways feel tired and lost my sex drive...besides bruxism. This makes me frustrated so I feel sad after 2 month of being not depressed (concerning mood).
> Any good results with this drug ? I hope to hear from really good responses.
>
> ben
This is the end of the thread.
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