Psycho-Babble Medication Thread 74402

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woman and amisulpride

Posted by angel1 on August 9, 2001, at 22:28:33

ARE THERE ANY WOMEN OUT THERE WHO HAVE HAD SUCCESS
WITH AMISULPRIDE WITHOUT A LOT OF SIDE EFFECTS?
I AM VERY INTERESTED IN THIS PARTICULAR MEDICATION
BUT AM HESITANT TO TRY IT DUE TO ADVERSE EFFECTS
ON THE ENDOCRINE SYSTEM. ANY INFO. IS APPREICIATED.

Re: woman and amisulpride » angel1

Posted by SalArmy4me on August 9, 2001, at 23:07:58

In reply to woman and amisulpride, posted by angel1 on August 9, 2001, at 22:28:33

I was able to find only one article that mentioned endocrine problems, and in it they didn't make it seem incredibly harmful to the patient:

Institution
Department of Psychiatry, University of Mainz, Germany.

Title
Neuroendocrine response to antipsychotics: effects of drug type and gender.

Source
Biological Psychiatry. 45(1):89-97, 1999 Jan 1.

Abstract
BACKGROUND: To study the influences of drug type and gender on the neuroendocrine response to neuroleptic treatment, we compared the endocrine actions of two neuroleptics with different receptor affinity profiles--a substituted benzamide, amisulpride, a selective D2-like dopamine antagonist; and a thioxanthene, flupenthixol, a mixed D1/D2-like antagonist also blocking serotonin, H1, and D1 receptors--on anterior pituitary hormone secretion in schizophrenic patients (DSM-III-R). METHODS: Blood was withdrawn at 15-min intervals to assess basal secretion of prolactin, growth hormone (GH), and thyroid-stimulating hormone (TSH). Four hundred micrograms of thyrotropin-releasing hormone (TRH) was injected i.v. to investigate drug effects on TRH-stimulated secretion of prolactin, TSH, and GH. RESULTS: Prolactin plasma levels were markedly elevated in both treatment groups. In female, but not in male patients, this elevation was significantly more pronounced under amisulpride than under flupenthixol. The prolactin response to TRH was significantly blunted by amisulpride only in male subjects. While basal TSH secretion was significantly increased by both compounds, TRH-stimulated TSH secretion was elevated only in patients treated with amisulpride. Low basal prolactin levels predicted improvement of negative symptoms in patients treated with amisulpride. CONCLUSIONS: Amisulpride's more pronounced endocrine effects may be a reflection of its distinguished pharmacology and pharmacokinetics.

Re: woman and amisulpride

Posted by Anna Laura on August 10, 2001, at 1:27:26

In reply to Re: woman and amisulpride » angel1, posted by SalArmy4me on August 9, 2001, at 23:07:58

> I was able to find only one article that mentioned endocrine problems, and in it they didn't make it seem incredibly harmful to the patient:
>
> Institution
> Department of Psychiatry, University of Mainz, Germany.
>
> Title
> Neuroendocrine response to antipsychotics: effects of drug type and gender.
>
> Source
> Biological Psychiatry. 45(1):89-97, 1999 Jan 1.
>
> Abstract
> BACKGROUND: To study the influences of drug type and gender on the neuroendocrine response to neuroleptic treatment, we compared the endocrine actions of two neuroleptics with different receptor affinity profiles--a substituted benzamide, amisulpride, a selective D2-like dopamine antagonist; and a thioxanthene, flupenthixol, a mixed D1/D2-like antagonist also blocking serotonin, H1, and D1 receptors--on anterior pituitary hormone secretion in schizophrenic patients (DSM-III-R). METHODS: Blood was withdrawn at 15-min intervals to assess basal secretion of prolactin, growth hormone (GH), and thyroid-stimulating hormone (TSH). Four hundred micrograms of thyrotropin-releasing hormone (TRH) was injected i.v. to investigate drug effects on TRH-stimulated secretion of prolactin, TSH, and GH. RESULTS: Prolactin plasma levels were markedly elevated in both treatment groups. In female, but not in male patients, this elevation was significantly more pronounced under amisulpride than under flupenthixol. The prolactin response to TRH was significantly blunted by amisulpride only in male subjects. While basal TSH secretion was significantly increased by both compounds, TRH-stimulated TSH secretion was elevated only in patients treated with amisulpride. Low basal prolactin levels predicted improvement of negative symptoms in patients treated with amisulpride. CONCLUSIONS: Amisulpride's more pronounced endocrine effects may be a reflection of its distinguished pharmacology and pharmacokinetics.

Hi Angel1,

Please be careful,

I've been taking an atypical antypsichotic similar to Amisulpride called Levosulpiride: it definetely affected my endocrine system (i'm having my period after 32 days instead of 23-25 as i used to do in the past twenty years) it did worsen my depression because of that unbalance.
Hormones do have an impact on your nervous system for good or for bad (they're connected), so please watch out before taking it.

P.S.
I couldn't handle the pill either.

Anna Laura

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