Psycho-Babble Medication Thread 71169

Shown: posts 1 to 14 of 14. This is the beginning of the thread.

 

Prozac plus Zyprexa Research

Posted by JohnL on July 21, 2001, at 5:13:59

Hi all,
I often speak highly of Prozac and Zyprexa at this board. One reason is because they have worked so well for me, when dozens of other drugs didn't. So right up front, I obviously have a little favorable bias. Listed below are the two clinical studies that led me to this magical combination. So it isn't just my experience, but it is also the experience of clinical studies that shows a lot of promise with these two drugs when combined.

Excellent research is available at www.mentalhealth.com. Follow the prompts for Medication Research. Choose Zyprexa as the drug for research, and choose 'All Topics'. When you arrive at the page that has all the research abstracts listed, you will see a box at the top with Olanzapine listed in it. You can erase it, and then type in 'Zyprexa AND Prozac', or Zyprexa AND TDR (treatment resistant depression), or whatever it is you might be interested in. Sexual concerns? Type in 'Prozac AND sexual', 'Zyprexa AND sexual', or whatever. You can creatively research any topic you want. Make sure to capitalize the word 'AND'.

I also really like the European drug Amisulpride, and I wish to God we had it in the USA. It blows away so many other meds. Here again, research is available. Type in 'Amisulpride', or maybe 'Amisulpride AND depression', or 'Amisulpride AND dysthymia', or 'Amisulpride AND anhedonia', or whatever it is you might be curious about.

Disclaimer. Mileage varies. And just like all psychiatric drugs, even my favorites can actually make things worse for some people. You'll see that in research too.

Finding the right drug is so often a hit and miss game. So I want to increase my odds of success. Research can help identify the best odds for success. In my own opinion, my own experience, and my own research, Prozac and Zyprexa should be way up high on anyone's list of drugs to try. Not just either alone, but both combined.

But maybe you don't like Prozac or Zyprexa. Maybe you are a big fan of Effexor. That's fine. You can also research that too. You can research anything you want easily. I hope this is helpful to someone.
1: Am J Psychiatry 2001 Jan;158(1):131-4
Related Articles, Books, LinkOut


A novel augmentation strategy for treating resistant
major depression.

Shelton RC, Tollefson GD, Tohen M, Stahl S, Gannon KS, Jacobs
TG, Buras WR, Bymaster FP, Zhang W, Spencer KA, Feldman
PD, Meltzer HY.

Department of Psychiatry, Vanderbilt University Medical Center,
Nashville, TN 37212, USA. richard.shelton@mcmail.vanderbilt.edu

OBJECTIVE: Treatment-resistant depression is a significant public health
concern; drug switching or augmentation often produce limited results.
The authors hypothesized that fluoxetine could be augmented with
olanzapine to successfully treat resistant depression. METHOD: An
8-week double-blind study was conducted with 28 patients who were
diagnosed with recurrent, nonbipolar, treatment-resistant depression
without psychotic features. Subjects were randomly assigned to one of
three groups: olanzapine plus placebo, fluoxetine plus placebo, or
olanzapine plus fluoxetine. RESULTS: Fluoxetine monotherapy produced
minimal improvement on various scales that rate severity of depression.
The benefits of olanzapine monotherapy were modest. Olanzapine plus
fluoxetine produced significantly greater improvement than either
monotherapy on one measure and significantly greater improvement than
olanzapine monotherapy on the other measures after 1 week. There were
no significant differences between treatment groups on extrapyramidal
measures nor significant adverse drug interactions. CONCLUSIONS:
Olanzapine plus fluoxetine demonstrated superior efficacy for treating
resistant depression compared to either agent alone.
1: Neuropsychopharmacology 2000 Sep;23(3):250-62
Related Articles, Books,
LinkOut


Synergistic effects of olanzapine and other
antipsychotic agents in combination with fluoxetine on
norepinephrine and dopamine release in rat prefrontal
cortex.

Zhang W, Perry KW, Wong DT, Potts BD, Bao J, Tollefson GD,
Bymaster FP.

Neuroscience Research Division, Lilly Research Laboratories, Lilly
Corporate Center, Indianapolis, IN 46285-0510, USA.

To understand the mechanism of the clinical efficacy of olanzapine and
fluoxetine combination therapy for treatment-resistant depression (TRD),
we studied the effects of olanzapine and other antipsychotics in
combination with the selective serotonin uptake inhibitors fluoxetine or
sertraline on neurotransmitter release in rat prefrontal cortex (PFC) using
microdialysis. The combination of olanzapine and fluoxetine produced
robust, sustained increases of extracellular levels of dopamine ([DA](ex))
and norepinephrine ([NE](ex)) up to 361 +/- 28% and 272 +/- 16% of the
baseline, respectively, which were significantly greater than either drug
alone. This combination produced a slightly smaller increase of serotonin
([5-HT](ex)) than fluoxetine alone. The combination of clozapine or
risperidone with fluoxetine produced less robust and persistent increases
of [DA](ex) and [NE](ex). The combination of haloperidol or MDL
100907 with fluoxetine did not increase the monoamines more than
fluoxetine alone. Olanzapine plus sertraline combination increased only
[DA](ex). Therefore, the large, sustained increase of [DA](ex),
[NE](ex), and [5-HT](ex) in PFC after olanzapine-fluoxetine treatment
was unique and may contribute to the profound antidepressive effect of
the olanzapine and fluoxetine therapy

 

Re: Prozac plus Zyprexa Research » JohnL

Posted by rod on July 21, 2001, at 10:19:18

In reply to Prozac plus Zyprexa Research, posted by JohnL on July 21, 2001, at 5:13:59

Hi JohnL,
At which dosage do (did) you take Prozac and Zyprexa?

 

Re: Prozac plus Zyprexa Research

Posted by judy1 on July 21, 2001, at 15:50:11

In reply to Re: Prozac plus Zyprexa Research » JohnL, posted by rod on July 21, 2001, at 10:19:18

I read somewhere, sorry the memory is shot here, that there is a prozac/zyprexa combo in the works- judy

 

Re: Prozac plus Zyprexa Research Rod

Posted by JohnL on July 21, 2001, at 19:22:26

In reply to Re: Prozac plus Zyprexa Research » JohnL, posted by rod on July 21, 2001, at 10:19:18

> Hi JohnL,
> At which dosage do (did) you take Prozac and Zyprexa?

Hi Rod,
I take 20mg Prozac with breakfast and 5mg Zyprexa after dinner. I also take the minimum dose, 300mg, of Adrafinil. All three are working in unison, but I can tell it's the Prozac and Zyprexa doing the heavy work. Oddly, none of them alone were all that great. It's like the sum is greater than the parts added together, if that makes any sense.
John

 

Re: Prozac plus Zyprexa Research

Posted by Joeypanic on July 22, 2001, at 4:22:03

In reply to Re: Prozac plus Zyprexa Research, posted by judy1 on July 21, 2001, at 15:50:11

I am convinced augmentation is the way to go.They should create a pill that has the chemical structure of prozac/zyprexa or a pill combing effexor/remeron.I have a question though.Why do u think it is prozac that augments with zyprexa so well? I am on zoloft and want to take zyprexa but will it have the same effect? Isn't zoloft more selective than prozac? I have panic/anxiety and think zyprexa calms me down very effectively.I am on zoloft and klonopin.I am trying choose between zyprexa and remeron to augment.

 

Re: Prozac plus Zyprexa Research

Posted by JohnL on July 22, 2001, at 17:14:06

In reply to Re: Prozac plus Zyprexa Research, posted by Joeypanic on July 22, 2001, at 4:22:03

> ....I am trying choose between zyprexa and remeron to augment.

Just my own opinion based on my own trials of these meds, but I like Zyprexa a lot better than Remeron. I was on Remeron for about a year. I never really did like it the whole time except that it knocked me out fast at bedtime. But the only reason I wanted to fall asleep fast, and early, was because I still had residual depression and I just had no desire to do anything. Sleep was escape, and Remeron helped me escape. Zyprexa, for me anyway, is real good. I like it. It does not knock me out like Remeron did, but then, I'm not in a hurry to escape anymore either. I feel good, and usually the days just aren't long enough to do everything I want to do.

But as you mentioned, augmentation might be the way to go. Zyprexa is not my only med. I also take the minimum doses of Prozac and Adrafinil.
John

 

Re: Prozac plus Zyprexa Research » Joeypanic

Posted by ChrisK on July 23, 2001, at 5:04:29

In reply to Re: Prozac plus Zyprexa Research, posted by Joeypanic on July 22, 2001, at 4:22:03

My own experience is that Zyprexa augments well with almost anything. I used it in combo with Nortriptyline, a TCA. I'm sure that if you are being helped by Zoloft that Zyprexa will not act any differently than it does with Prozac. The reason the studies concentrate on Prozac/Zyprexa is quite simply that Lilly produces both and they spent the money to sponser the research. IMO, that alone does not discredit the results but it is the reason you don't see much on Zyprexa with other combos.

> I am convinced augmentation is the way to go.They should create a pill that has the chemical structure of prozac/zyprexa or a pill combing effexor/remeron.I have a question though.Why do u think it is prozac that augments with zyprexa so well? I am on zoloft and want to take zyprexa but will it have the same effect? Isn't zoloft more selective than prozac? I have panic/anxiety and think zyprexa calms me down very effectively.I am on zoloft and klonopin.I am trying choose between zyprexa and remeron to augment.

 

Re: Prozac plus Zyprexa Research

Posted by Else on July 23, 2001, at 6:06:58

In reply to Prozac plus Zyprexa Research, posted by JohnL on July 21, 2001, at 5:13:59

Sorry for my scepticism, you sound convincing, but aren't both these drugs made by Ely Lilly?


> Hi all,
> I often speak highly of Prozac and Zyprexa at this board. One reason is because they have worked so well for me, when dozens of other drugs didn't. So right up front, I obviously have a little favorable bias. Listed below are the two clinical studies that led me to this magical combination. So it isn't just my experience, but it is also the experience of clinical studies that shows a lot of promise with these two drugs when combined.
>
> Excellent research is available at www.mentalhealth.com. Follow the prompts for Medication Research. Choose Zyprexa as the drug for research, and choose 'All Topics'. When you arrive at the page that has all the research abstracts listed, you will see a box at the top with Olanzapine listed in it. You can erase it, and then type in 'Zyprexa AND Prozac', or Zyprexa AND TDR (treatment resistant depression), or whatever it is you might be interested in. Sexual concerns? Type in 'Prozac AND sexual', 'Zyprexa AND sexual', or whatever. You can creatively research any topic you want. Make sure to capitalize the word 'AND'.
>
> I also really like the European drug Amisulpride, and I wish to God we had it in the USA. It blows away so many other meds. Here again, research is available. Type in 'Amisulpride', or maybe 'Amisulpride AND depression', or 'Amisulpride AND dysthymia', or 'Amisulpride AND anhedonia', or whatever it is you might be curious about.
>
> Disclaimer. Mileage varies. And just like all psychiatric drugs, even my favorites can actually make things worse for some people. You'll see that in research too.
>
> Finding the right drug is so often a hit and miss game. So I want to increase my odds of success. Research can help identify the best odds for success. In my own opinion, my own experience, and my own research, Prozac and Zyprexa should be way up high on anyone's list of drugs to try. Not just either alone, but both combined.
>
> But maybe you don't like Prozac or Zyprexa. Maybe you are a big fan of Effexor. That's fine. You can also research that too. You can research anything you want easily. I hope this is helpful to someone.
> 1: Am J Psychiatry 2001 Jan;158(1):131-4
> Related Articles, Books, LinkOut
>
>
> A novel augmentation strategy for treating resistant
> major depression.
>
> Shelton RC, Tollefson GD, Tohen M, Stahl S, Gannon KS, Jacobs
> TG, Buras WR, Bymaster FP, Zhang W, Spencer KA, Feldman
> PD, Meltzer HY.
>
> Department of Psychiatry, Vanderbilt University Medical Center,
> Nashville, TN 37212, USA. richard.shelton@mcmail.vanderbilt.edu
>
> OBJECTIVE: Treatment-resistant depression is a significant public health
> concern; drug switching or augmentation often produce limited results.
> The authors hypothesized that fluoxetine could be augmented with
> olanzapine to successfully treat resistant depression. METHOD: An
> 8-week double-blind study was conducted with 28 patients who were
> diagnosed with recurrent, nonbipolar, treatment-resistant depression
> without psychotic features. Subjects were randomly assigned to one of
> three groups: olanzapine plus placebo, fluoxetine plus placebo, or
> olanzapine plus fluoxetine. RESULTS: Fluoxetine monotherapy produced
> minimal improvement on various scales that rate severity of depression.
> The benefits of olanzapine monotherapy were modest. Olanzapine plus
> fluoxetine produced significantly greater improvement than either
> monotherapy on one measure and significantly greater improvement than
> olanzapine monotherapy on the other measures after 1 week. There were
> no significant differences between treatment groups on extrapyramidal
> measures nor significant adverse drug interactions. CONCLUSIONS:
> Olanzapine plus fluoxetine demonstrated superior efficacy for treating
> resistant depression compared to either agent alone.
> 1: Neuropsychopharmacology 2000 Sep;23(3):250-62
> Related Articles, Books,
> LinkOut
>
>
> Synergistic effects of olanzapine and other
> antipsychotic agents in combination with fluoxetine on
> norepinephrine and dopamine release in rat prefrontal
> cortex.
>
> Zhang W, Perry KW, Wong DT, Potts BD, Bao J, Tollefson GD,
> Bymaster FP.
>
> Neuroscience Research Division, Lilly Research Laboratories, Lilly
> Corporate Center, Indianapolis, IN 46285-0510, USA.
>
> To understand the mechanism of the clinical efficacy of olanzapine and
> fluoxetine combination therapy for treatment-resistant depression (TRD),
> we studied the effects of olanzapine and other antipsychotics in
> combination with the selective serotonin uptake inhibitors fluoxetine or
> sertraline on neurotransmitter release in rat prefrontal cortex (PFC) using
> microdialysis. The combination of olanzapine and fluoxetine produced
> robust, sustained increases of extracellular levels of dopamine ([DA](ex))
> and norepinephrine ([NE](ex)) up to 361 +/- 28% and 272 +/- 16% of the
> baseline, respectively, which were significantly greater than either drug
> alone. This combination produced a slightly smaller increase of serotonin
> ([5-HT](ex)) than fluoxetine alone. The combination of clozapine or
> risperidone with fluoxetine produced less robust and persistent increases
> of [DA](ex) and [NE](ex). The combination of haloperidol or MDL
> 100907 with fluoxetine did not increase the monoamines more than
> fluoxetine alone. Olanzapine plus sertraline combination increased only
> [DA](ex). Therefore, the large, sustained increase of [DA](ex),
> [NE](ex), and [5-HT](ex) in PFC after olanzapine-fluoxetine treatment
> was unique and may contribute to the profound antidepressive effect of
> the olanzapine and fluoxetine therapy

 

Re: Prozac plus Zyprexa Research

Posted by Roo on July 23, 2001, at 7:46:39

In reply to Re: Prozac plus Zyprexa Research, posted by Else on July 23, 2001, at 6:06:58

Did I hear somewhere that most people gain weight
on Zyprexa (a concern of mine)?
John, did you say it also helps to combat sexual
side effects of the prozac?

 

Re: Prozac plus Zyprexa Research

Posted by djmmm on July 23, 2001, at 20:50:18

In reply to Re: Prozac plus Zyprexa Research, posted by Joeypanic on July 22, 2001, at 4:22:03

> I am convinced augmentation is the way to go.They should create a pill that has the chemical structure of prozac/zyprexa or a pill combing effexor/remeron.I have a question though.Why do u think it is prozac that augments with zyprexa so well? I am on zoloft and want to take zyprexa but will it have the same effect? Isn't zoloft more selective than prozac? I have panic/anxiety and think zyprexa calms me down very effectively.I am on zoloft and klonopin.I am trying choose between zyprexa and remeron to augment.

ChrisK is correct..the only reason they are combined is because they are both Lilly products...Zoloft is a good deal more selective than Prozac, and several times more potent.

 

Re: Prozac plus Zyprexa Research » Else

Posted by Sunnely on July 23, 2001, at 23:33:48

In reply to Re: Prozac plus Zyprexa Research, posted by Else on July 23, 2001, at 6:06:58

Not only that Lilly makes both drugs (Prozac and Zyprexa), they also sponsored this small sample study, and at least one of the main clinical investigators is in Lilly's payrol (Tollefson). However, IMHO, Lilly's interest with this combination may be waning since generic Prozac (Barr Labs) is soon to be released.

You may have also encountered in recent psychiatric literature revealing the result of a study which indicates that patients on Zyprexa who received 150 mg and 300 mg of nizatidine (Axid) daily, a H2-blocker, gained significantly less weight gain than those who received placebo. The weight gain was lower and was observed to plateau more quickly with the higher doses of Axid. Guess which drug company sponsored this study and incidentally, also makes both drugs (Axid and Zyprexa)?

> Sorry for my scepticism, you sound convincing, but aren't both these drugs made by Ely Lilly?

 

Re: Prozac plus Zyprexa Research Roo

Posted by JohnL on July 24, 2001, at 2:09:28

In reply to Re: Prozac plus Zyprexa Research, posted by Roo on July 23, 2001, at 7:46:39

> Did I hear somewhere that most people gain weight
> on Zyprexa (a concern of mine)?
> John, did you say it also helps to combat sexual
> side effects of the prozac?


Hi Roo,
Yes, Zyprexa is famous for weight gain. However, in my own experience, it levels off at about 6 to 8 weeks. I gained 10 pounds almost immediately, but since then have lost it all without even trying.

There is a cool trick to deal with the weight gain. Simply drink a large glass of water before meals or before snacks. That's it. Zyprexa tends to make you feel hungrier than you really are, and hungrier more often than you really are. Just fill the tummy with water and that way you can easily battle the false appetite thing and eat whatever you want whenever you want.

For me Zyprexa has been sexually friendly. I believe that is for two reasons, though both are just theories. One is that it blocks the serotonin receptors that are involved in sexual dysfunction. The other is the I believe low doses of Zyprexa stimulate dopamine, which is beneficial for sex.
JOhn

 

Re: Prozac plus Zyprexa Research

Posted by Else on July 24, 2001, at 6:15:54

In reply to Re: Prozac plus Zyprexa Research » Else, posted by Sunnely on July 23, 2001, at 23:33:48

The "coincidences" seem rather frequent in research though. I don't think Ely Lilly is the only culprit. For instance, in a research comparing the sexual side-effects of Wellbutrin with those of SSRIs, the SSRI picked for the study was Zoloft, not GSK's own Paxil.Could this have anything to do with the fact that GSK makes both drugs? Uhhhh, maybe...
That doesn't mean the Prozac-Zyprexa combination isn't effective. It may well be. But other possibly very effective combinations might not get a fair chance because of these well-financed studies of "inbred" meds.


> Not only that Lilly makes both drugs (Prozac and Zyprexa), they also sponsored this small sample study, and at least one of the main clinical investigators is in Lilly's payrol (Tollefson). However, IMHO, Lilly's interest with this combination may be waning since generic Prozac (Barr Labs) is soon to be released.
>
> You may have also encountered in recent psychiatric literature revealing the result of a study which indicates that patients on Zyprexa who received 150 mg and 300 mg of nizatidine (Axid) daily, a H2-blocker, gained significantly less weight gain than those who received placebo. The weight gain was lower and was observed to plateau more quickly with the higher doses of Axid. Guess which drug company sponsored this study and incidentally, also makes both drugs (Axid and Zyprexa)?
>
> > Sorry for my scepticism, you sound convincing, but aren't both these drugs made by Ely Lilly?

 

Re: John thank you for this analysis eom » JohnL

Posted by Lorraine on July 24, 2001, at 9:46:37

In reply to Prozac plus Zyprexa Research, posted by JohnL on July 21, 2001, at 5:13:59

> Hi all,
> I often speak highly of Prozac and Zyprexa at this board. One reason is because they have worked so well for me, when dozens of other drugs didn't. So right up front, I obviously have a little favorable bias. Listed below are the two clinical studies that led me to this magical combination. So it isn't just my experience, but it is also the experience of clinical studies that shows a lot of promise with these two drugs when combined.
>
> Excellent research is available at www.mentalhealth.com. Follow the prompts for Medication Research. Choose Zyprexa as the drug for research, and choose 'All Topics'. When you arrive at the page that has all the research abstracts listed, you will see a box at the top with Olanzapine listed in it. You can erase it, and then type in 'Zyprexa AND Prozac', or Zyprexa AND TDR (treatment resistant depression), or whatever it is you might be interested in. Sexual concerns? Type in 'Prozac AND sexual', 'Zyprexa AND sexual', or whatever. You can creatively research any topic you want. Make sure to capitalize the word 'AND'.
>
> I also really like the European drug Amisulpride, and I wish to God we had it in the USA. It blows away so many other meds. Here again, research is available. Type in 'Amisulpride', or maybe 'Amisulpride AND depression', or 'Amisulpride AND dysthymia', or 'Amisulpride AND anhedonia', or whatever it is you might be curious about.
>
> Disclaimer. Mileage varies. And just like all psychiatric drugs, even my favorites can actually make things worse for some people. You'll see that in research too.
>
> Finding the right drug is so often a hit and miss game. So I want to increase my odds of success. Research can help identify the best odds for success. In my own opinion, my own experience, and my own research, Prozac and Zyprexa should be way up high on anyone's list of drugs to try. Not just either alone, but both combined.
>
> But maybe you don't like Prozac or Zyprexa. Maybe you are a big fan of Effexor. That's fine. You can also research that too. You can research anything you want easily. I hope this is helpful to someone.
> 1: Am J Psychiatry 2001 Jan;158(1):131-4
> Related Articles, Books, LinkOut
>
>
> A novel augmentation strategy for treating resistant
> major depression.
>
> Shelton RC, Tollefson GD, Tohen M, Stahl S, Gannon KS, Jacobs
> TG, Buras WR, Bymaster FP, Zhang W, Spencer KA, Feldman
> PD, Meltzer HY.
>
> Department of Psychiatry, Vanderbilt University Medical Center,
> Nashville, TN 37212, USA. richard.shelton@mcmail.vanderbilt.edu
>
> OBJECTIVE: Treatment-resistant depression is a significant public health
> concern; drug switching or augmentation often produce limited results.
> The authors hypothesized that fluoxetine could be augmented with
> olanzapine to successfully treat resistant depression. METHOD: An
> 8-week double-blind study was conducted with 28 patients who were
> diagnosed with recurrent, nonbipolar, treatment-resistant depression
> without psychotic features. Subjects were randomly assigned to one of
> three groups: olanzapine plus placebo, fluoxetine plus placebo, or
> olanzapine plus fluoxetine. RESULTS: Fluoxetine monotherapy produced
> minimal improvement on various scales that rate severity of depression.
> The benefits of olanzapine monotherapy were modest. Olanzapine plus
> fluoxetine produced significantly greater improvement than either
> monotherapy on one measure and significantly greater improvement than
> olanzapine monotherapy on the other measures after 1 week. There were
> no significant differences between treatment groups on extrapyramidal
> measures nor significant adverse drug interactions. CONCLUSIONS:
> Olanzapine plus fluoxetine demonstrated superior efficacy for treating
> resistant depression compared to either agent alone.
> 1: Neuropsychopharmacology 2000 Sep;23(3):250-62
> Related Articles, Books,
> LinkOut
>
>
> Synergistic effects of olanzapine and other
> antipsychotic agents in combination with fluoxetine on
> norepinephrine and dopamine release in rat prefrontal
> cortex.
>
> Zhang W, Perry KW, Wong DT, Potts BD, Bao J, Tollefson GD,
> Bymaster FP.
>
> Neuroscience Research Division, Lilly Research Laboratories, Lilly
> Corporate Center, Indianapolis, IN 46285-0510, USA.
>
> To understand the mechanism of the clinical efficacy of olanzapine and
> fluoxetine combination therapy for treatment-resistant depression (TRD),
> we studied the effects of olanzapine and other antipsychotics in
> combination with the selective serotonin uptake inhibitors fluoxetine or
> sertraline on neurotransmitter release in rat prefrontal cortex (PFC) using
> microdialysis. The combination of olanzapine and fluoxetine produced
> robust, sustained increases of extracellular levels of dopamine ([DA](ex))
> and norepinephrine ([NE](ex)) up to 361 +/- 28% and 272 +/- 16% of the
> baseline, respectively, which were significantly greater than either drug
> alone. This combination produced a slightly smaller increase of serotonin
> ([5-HT](ex)) than fluoxetine alone. The combination of clozapine or
> risperidone with fluoxetine produced less robust and persistent increases
> of [DA](ex) and [NE](ex). The combination of haloperidol or MDL
> 100907 with fluoxetine did not increase the monoamines more than
> fluoxetine alone. Olanzapine plus sertraline combination increased only
> [DA](ex). Therefore, the large, sustained increase of [DA](ex),
> [NE](ex), and [5-HT](ex) in PFC after olanzapine-fluoxetine treatment
> was unique and may contribute to the profound antidepressive effect of
> the olanzapine and fluoxetine therapy


This is the end of the thread.


Show another thread

URL of post in thread:


Psycho-Babble Medication | Extras | FAQ


[dr. bob] Dr. Bob is Robert Hsiung, MD, bob@dr-bob.org

Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.