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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by manowar on June 19, 2001, at 12:59:52
I've never heard of it before. I read some of the posts back in Febuary, but none since. Can it be purchased overseas w/o script? Why aren't there more dopaminergic drugs out there for depression? If anyone is using it please let me know how you're doing. Thanks
Posted by Peter S on June 19, 2001, at 14:49:05
In reply to Where can I find Mirapex?, posted by manowar on June 19, 2001, at 12:59:52
Mirapex is a drug that is used to treat Parkinson's and is available in the US. It is not prescribed for depression. However there have been a couple of studies (and anecdotal reports) that have show that it can be effective in treating depression. There is another similar drug called Requip (ropinorole sp?).
For more details see Chris's post during the last period. He found it to be very effective.
I just started taking it. I will definitely post my results.
Peter
> I've never heard of it before. I read some of the posts back in Febuary, but none since. Can it be purchased overseas w/o script? Why aren't there more dopaminergic drugs out there for depression? If anyone is using it please let me know how you're doing. Thanks
Posted by SalArmy4me on June 19, 2001, at 15:35:43
In reply to Where can I find Mirapex?, posted by manowar on June 19, 2001, at 12:59:52
Here is the low-down on Mirapex:
--It has a benign side-effect profile, with most patients reporting nausea as the main side-effect. But that side-effect may have been from the levodopa that the Parkinsons' patients were also taking during the clinical trials.
--Mirapex is definitely less expensive than Prozac or Wellbutrin. 100 of the 1.5 mg Mirapex tablets costs $80 on insurance at the largest HMO in the US. Prozac and Paxil are definitely more costly.
--It has few anticholinergic effects.
--It is not known to cause sexual dysfunction.
--Though it probably has to be taken three times a day, so does Neurontin, Wellbutrin IR, Effexor IR, and Visken.
--Mirapex has two studies done on it in non-Parkinsons' patients--one for unipolar depression and the other for bipolar disorder.
--It has minimal drug interactions as compared to Tricylcics Antidepressants or MAOI's (& RIMA's).Thus, if it works for you, its a good deal.
-Studies on Medline:
2. Pramipexole augmentation in the treatment of unipolar and bipolar depression: a retrospective chart review Ann Clin Psychiatry. 2000 Sep;12(3):137-40. [Record as supplied by publisher] PMID: 10984002
3:
Maj J, Rogoz Z.
Related Articles
Synergistic effect of pramipexole and sertraline in the forced swimming test. Pol J Pharmacol. 1999 Nov-Dec;51(6):471-5.
PMID: 10817524
4: Corrigan MH, Denahan AQ, Wright CE, Ragual RJ, Evans DL. Related Articles Comparison of pramipexole, fluoxetine, and placebo in patients with major depression. Depress Anxiety. 2000;11(2):58-65. PMID: 10812530
5: DeBattista C, Solvason HB, Breen JA, Schatzberg AF. Related Articles Pramipexole augmentation of a selective serotonin reuptake inhibitor in the treatment of depression. J Clin Psychopharmacol. 2000 Apr;20(2):274-5. No abstract available. PMID: 10770475
6:
Goldberg JF, Frye MA, Dunn RT.
Related Articles
Pramipexole in refractory bipolar depression.
Am J Psychiatry. 1999 May;156(5):798. No abstract available.
PMID: 10327923
7:
Bennett JP, Piercey MF.
Related Articles
Pramipexole--a new dopamine agonist for the treatment of Parkinson's disease. J Neurol Sci. 1999 Feb 1;163(1):25-31. Review.
PMID: 10223406
8: Piercey MF. Related Articles Pharmacology of pramipexole, a dopamine D3-preferring agonist useful in treating Parkinson's disease. Clin Neuropharmacol. 1998 May-Jun;21(3):141-51. Review. PMID: 9617505
9:
Willner P.
Related Articles
The mesolimbic dopamine system as a target for rapid antidepressant action. Int Clin Psychopharmacol. 1997 Jul;12 Suppl 3:S7-14. Review.
PMID: 9347387
Posted by ChrisK on June 19, 2001, at 15:49:06
In reply to Where can I find Mirapex?, posted by manowar on June 19, 2001, at 12:59:52
Please see my post just above "There is Hope for Everyone." Mirapex has worked great for me. Others have had varied results but there are studies now that show that Mirapex has ann antidepressant side to it. It is available in the US and is easily prescribed.
> I've never heard of it before. I read some of the posts back in Febuary, but none since. Can it be purchased overseas w/o script? Why aren't there more dopaminergic drugs out there for depression? If anyone is using it please let me know how you're doing. Thanks
Posted by Peter S on June 19, 2001, at 20:07:18
In reply to Where can I find Mirapex?, posted by manowar on June 19, 2001, at 12:59:52
Mirapex is a drug that is used to treat Parkinson's and is available in the US. It is not prescribed for depression. However there have been a couple of studies (and anecdotal reports) that have show that it can be effective in treating depression. There is another similar drug called Requip (ropinorole sp?).
For more details see Chris's post during the last period. He found it to be very effective.
I just started taking it. I will definitely post my results.
Peter
> I've never heard of it before. I read some of the posts back in Febuary, but none since. Can it be purchased overseas w/o script? Why aren't there more dopaminergic drugs out there for depression? If anyone is using it please let me know how you're doing. Thanks
This is the end of the thread.
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