![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by GANDALF on May 11, 2001, at 10:56:04
Does anybody have some personal experience of using procaine as an *antidepressant*(vs an anti-aging) medication. Procaine is found in products like Gerovital and Salusa 45 (South African product). It allegedly has MAOI type effects which are mild and reversible (i.e., you don't have to go on an MAOI diet). Any links to *scientific* information would also be appreciated.
Thanx
GANDALF
Posted by jarlath on May 11, 2001, at 11:41:19
In reply to Does Procaine have antidepressant (MAOI) effects?, posted by GANDALF on May 11, 2001, at 10:56:04
Procaine is an ester local anesthetic. It is metabolized rapidly by plasma cholinesterases in the blood stream, so I would not think it would have much of any lasting effect. Local anesthetics are CNS depressants, but in very high (toxic) doses can cause CNS stimulation (presumably by depressing inhibitory centers), seizures etc. I am unaware of any MOAI effects, or contraindications in using them in patients on MAOI's. I am assuming that the "procaine" you are refering to is the local anesthetic. I know of no others.
Hope this is helpful,
Jarlath (anesthesiologist)
Posted by SalArmy4me on May 11, 2001, at 12:24:38
In reply to Does Procaine have antidepressant (MAOI) effects?, posted by GANDALF on May 11, 2001, at 10:56:04
From JAMA Volume 158(7) 13 April 1998 pp 705-712
Effectiveness of Treatments of Depression in Older Ambulatory Patients
[Original Investigation]
McCusker, Jane MD, DrPh; Cole, Martin MD; Keller, Evelyn MD, MSc; Bellavance, Francois PhD; Berard, Anick MSc"...Among 9 other individual comparisons that did not use the HDRS, not included in these comparison groups, only those of Gerovital H3 (a solution containing 2% procaine hydrochloride with benzoic acid as a preservative and potassium metabisulfite as an antioxidant) vs either imipramine or placebo [67] and reminiscence therapy vs attention controls [33] showed a significant benefit of treatment."
> Does anybody have some personal experience of using procaine as an *antidepressant*(vs an anti-aging) medication. Procaine is found in products like Gerovital and Salusa 45 (South African product). It allegedly has MAOI type effects which are mild and reversible (i.e., you don't have to go on an MAOI diet). Any links to *scientific* information would also be appreciated.
>
> Thanx
> GANDALF
Posted by Michele on May 11, 2001, at 20:47:24
In reply to Re: Does Procaine have antidepressant (MAOI) effects?, posted by jarlath on May 11, 2001, at 11:41:19
Jarlath,
The procaine he's referring to.... like in Gh3... also containes other ingredients that keep it in you system longer.....
Posted by SLS on May 12, 2001, at 12:10:56
In reply to Does Procaine have antidepressant (MAOI) effects?, posted by GANDALF on May 11, 2001, at 10:56:04
> Does anybody have some personal experience of using procaine as an *antidepressant*(vs an anti-aging) medication. Procaine is found in products like Gerovital and Salusa 45 (South African product). It allegedly has MAOI type effects which are mild and reversible (i.e., you don't have to go on an MAOI diet). Any links to *scientific* information would also be appreciated.
>
Hi.The NIMH (National Institute of Mental Health) has used procaine in the past as a "challenge" to see how people would react to it while their vital signs and brain function were being recorded. They found its psychiatric effects to be highly variable. I know of one person for whom procaine was the only drug to produce a state of relief from his chronic depression. Unfortunately, it lasted for less than an hour. Others reacted to it by becoming very hostile, dysphoric, and even psychotic. I don't know what dosages they used, but I'm pretty sure procaine was administered intravenously
- Scott
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.