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Dr. Bob is Robert Hsiung, MD,
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Posted by ben on February 16, 2001, at 9:53:30
Hi babblers
Did anyone have experience in augmentation
of an antidepressant (ssri or mirtazapine) with a neuroleptic like amisulpride (Solian) or risperidone (Risperdal).
I suffer from melancholic depression with negative symptoms like low self esteem, lack of motivation,
social retrieve....
Which neuroleptic is the better mood booster and stabilizer in combo with an ssri or mirtazapine ?
I have heard of case reports doing remission within a week by adjunct of Risperdal to an SSRI.
Many thanks for your replies
Posted by michael on February 16, 2001, at 12:42:49
In reply to amisulpride vs. risperidone, posted by ben on February 16, 2001, at 9:53:30
Just wondering if anyone can tell us if they work on the same neurotransmitters/receptors/etc? Or more to the point, how they differ? (amisulpride & risperidone)
> Hi babblers
> Did anyone have experience in augmentation
> of an antidepressant (ssri or mirtazapine) with a neuroleptic like amisulpride (Solian) or risperidone (Risperdal).
> I suffer from melancholic depression with negative symptoms like low self esteem, lack of motivation,
> social retrieve....
> Which neuroleptic is the better mood booster and stabilizer in combo with an ssri or mirtazapine ?
> I have heard of case reports doing remission within a week by adjunct of Risperdal to an SSRI.
> Many thanks for your replies
Posted by JohnL on February 17, 2001, at 10:21:51
In reply to amisulpride vs. risperidone, posted by ben on February 16, 2001, at 9:53:30
Hi Ben,
The type of depression I have is exactly like what you described. I have done very well with a cocktail that involves antidepressants and antipsychotics, with a stimulant for good measure.Currently I take 300mg Adrafinil (mild stimulant, lowest dose), 25mg Amisulpride (antipsychotic, one half the lowest dose), 20mg Prozac, and 5mg Zyprexa (antipsychotic). Previously the cocktail included Remeron for sleep instead of Zyprexa. Zyprexa doesn't put me to sleep as fast as Remeron did, but I sleep better, and the overall effect on my depression is better than Remeron was.
My favorite neuroleptics are obviously Amisulpride and Zyprexa. I take both, although in very low doses. I don't believe any one drug in my cocktail is the superstar. They all act in a teamwork fashion. Very effective against the kind of depression you described. I have discovered that if I remove just one of the drugs, I don't do as well. They are all contributing to my wellness.
John
Posted by ben on February 17, 2001, at 11:10:37
In reply to Re: amisulpride vs. risperidone, posted by JohnL on February 17, 2001, at 10:21:51
> Hi Ben,
> The type of depression I have is exactly like what you described. I have done very well with a cocktail that involves antidepressants and antipsychotics, with a stimulant for good measure.
>
> Currently I take 300mg Adrafinil (mild stimulant, lowest dose), 25mg Amisulpride (antipsychotic, one half the lowest dose), 20mg Prozac, and 5mg Zyprexa (antipsychotic). Previously the cocktail included Remeron for sleep instead of Zyprexa. Zyprexa doesn't put me to sleep as fast as Remeron did, but I sleep better, and the overall effect on my depression is better than Remeron was.
>
> My favorite neuroleptics are obviously Amisulpride and Zyprexa. I take both, although in very low doses. I don't believe any one drug in my cocktail is the superstar. They all act in a teamwork fashion. Very effective against the kind of depression you described. I have discovered that if I remove just one of the drugs, I don't do as well. They are all contributing to my wellness.
> JohnMany Thanks John
Do you know the difference between Risperidone and Amisulpride ? Are they both good augmentation adjuncts and mood stabilizers ? Which one has lesser side effects ? Are they sedating ?
Currently I take 60 mg Celexa and 7.5 mg Remeron. Since I take the remeron my mood is a bit better, but I am too sedated during the day and I got headaches. Unfortunaly I dont know if it comes from the Remeron or the combo, because I decreased the Celexa from 80 to 60 mg when I started with the Remeron (had some fear of serotoninergic syndrome ;-)).
I think mirtazapine has the ondansetron (Zofran) structure in his molecule which could be a hint to the headaches. Ondansetron blocks the 5TH3 receptors (antiemetika) and headaches are often reported as adverse effects. Do you think that increasing the remeron leads to fewer sedation as it has often been reported (increasing noradrenaline covers the sedation of histamine blocking)?
Ben
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