Shown: posts 1 to 22 of 22. This is the beginning of the thread.
Posted by JohnL on November 7, 2000, at 4:27:33
I need some help from my drug expert buddies out there.
As everyone knows, I've done extremely well with low doses of Amisulpride+Adrafinil. I have one and only one side effect. But it's a bad one. Impotence.
My pdoc retired. My GP moved away. Out in the cold, I had to find a new doc. I found one. I spent no time researching, I just sought the GP nearest to where I live. As it turns out, I got lucky, he's awesome. We discussed everything in detail, but still I need feedback from folks here at this board.
His first suggestion was to try Viagra. I didn't like Viagra, but may have to revisit that option if all else fails.
His second suggestion was to try me on one week of extended release Ritalin instead of Adrafinil, and then one week of Adderall. I couldn't believe it! Has this guy been reading Jensen stuff, or what?
If these trials don't turn out well for whatever reason, then next he would have me restart the Adrafinil, and possibly try an alpha-1 antagonist to counteract it on an as-needed basis. I think he mentioned Prazosin. This maybe in combination with Viagra.
In the end, if all these things fail, then he would have me consider longterm trial of Wellbutrin in addition to my other drugs.
My question to you all is this...Do you think an alpha-1 antagonist like Prazosin could counteract the agonist activity of Adrafinil? I read one clinical study where Prazosin did do that to Provigil. But I also wonder if that is something that could happen right away, or whether it is something that would take time. I mean, Adrafinil takes time to work. From what I've read about Prazosin, it takes time too. I wonder if it would have any effect on an as-needed basis.
I also noticed there is a drug called Nicergoline that is also an alpha-1 antagonist which is supposedly much more competitively powerful in site binding than Prazosin.
Anyway, I was surprised to find a doc who had no problem with my current meds, and who is willing to tweek out the details. A soft lifeless genital organ is my concern. He says this soft relaxed muscle condition is common with any alpha or beta agonist. I would welcome any and all feedback from anyone.
Thank you,
John
Posted by Maniz on November 7, 2000, at 8:22:25
In reply to Need Some Drug Advice, posted by JohnL on November 7, 2000, at 4:27:33
Hi,
I am sorry for this side effect you are having.
Do you think Yohimbe could help?
"
Yohimbe bark contains about 6% yohimbine. This constituent is an indole alkaloid that is classified as an alpha-2-adrenergic blocking agent. The herb has a general nervous system stimulatory effect and can cause changes in blood pressure by dilating blood vessels. It can increase the heart rate, raise body temperature and increase blood pressure. At higher dosages, it has a mild psychotropic effect. "Also, I know Ginkgo Biloba is used to help with SSRI side sexual effects. Although, you are not taking a SSRI.
Hydergine is an alpha 2 blocker too.
You can check www.life-enhancement.com for info and products with yohimbe, ginkgo, arginine, etc for prosexual effect.
Sorry I do not have better info.
> I need some help from my drug expert buddies out there.
>
> As everyone knows, I've done extremely well with low doses of Amisulpride+Adrafinil. I have one and only one side effect. But it's a bad one. Impotence.
>
> My pdoc retired. My GP moved away. Out in the cold, I had to find a new doc. I found one. I spent no time researching, I just sought the GP nearest to where I live. As it turns out, I got lucky, he's awesome. We discussed everything in detail, but still I need feedback from folks here at this board.
>
> His first suggestion was to try Viagra. I didn't like Viagra, but may have to revisit that option if all else fails.
>
> His second suggestion was to try me on one week of extended release Ritalin instead of Adrafinil, and then one week of Adderall. I couldn't believe it! Has this guy been reading Jensen stuff, or what?
>
> If these trials don't turn out well for whatever reason, then next he would have me restart the Adrafinil, and possibly try an alpha-1 antagonist to counteract it on an as-needed basis. I think he mentioned Prazosin. This maybe in combination with Viagra.
>
> In the end, if all these things fail, then he would have me consider longterm trial of Wellbutrin in addition to my other drugs.
>
> My question to you all is this...Do you think an alpha-1 antagonist like Prazosin could counteract the agonist activity of Adrafinil? I read one clinical study where Prazosin did do that to Provigil. But I also wonder if that is something that could happen right away, or whether it is something that would take time. I mean, Adrafinil takes time to work. From what I've read about Prazosin, it takes time too. I wonder if it would have any effect on an as-needed basis.
>
> I also noticed there is a drug called Nicergoline that is also an alpha-1 antagonist which is supposedly much more competitively powerful in site binding than Prazosin.
>
> Anyway, I was surprised to find a doc who had no problem with my current meds, and who is willing to tweek out the details. A soft lifeless genital organ is my concern. He says this soft relaxed muscle condition is common with any alpha or beta agonist. I would welcome any and all feedback from anyone.
> Thank you,
> John
Posted by Seamus2 on November 7, 2000, at 10:09:52
In reply to Need Some Drug Advice, posted by JohnL on November 7, 2000, at 4:27:33
> As everyone knows, I've done extremely well with low doses of Amisulpride+Adrafinil. I have one and only one side effect. But it's a bad one. Impotence.
>
> If these trials don't turn out well for whatever reason, then next he would have me restart the Adrafinil, and possibly try an alpha-1 antagonist to counteract it on an as-needed basis. I think he mentioned Prazosin. This maybe in combination with Viagra.John,
I'll guinea pig for you. I tried doxazosin (another alpha1 antagonist) for BPH and though it helped it also caused too much fatigue to continue. I'll start taking again for a few days and see if woody gets his wood back and let you know.
You saw my previous reply re hyperprolactinemia? There's another agent besides bromocriptine, but I can't recall the name.
Regards,
Seamus
Posted by cole on November 7, 2000, at 11:48:36
In reply to Need Some Drug Advice, posted by JohnL on November 7, 2000, at 4:27:33
I am a female, so what works for me may not necessarily work for you, however I have found that small doses (~5mg) of ritalin really helps with AD related anorgasmia and sexual apathy. The remeron seems to make me indifferent to sex, but the ritalin brings me back to normal. I take it about 10-15 min before sexual activity and it completely revives my interest and pleasure in sex. I don't know if you could take it along with the other meds, but that's what works for me. Good luck.
Cole
Posted by dove on November 7, 2000, at 13:53:54
In reply to Re: Need Some Drug Advice » JohnL, posted by cole on November 7, 2000, at 11:48:36
Once again, I'm a female and YMMV and usually does :-) Low dose Serzone (100mgs at bed-time/or whenever :-) kicked my anorgasmia in the rear. In regard to sexual apathy, losing the SSRI (Prozac in this case) and eventually the Wellbutrin did wonders. The fear-factor took a bit more work (or lack of work as the case may be). I had started to associate intimacy with disaster, but after some time without anorgasmia I started to relax and that in itself increased the sexual apathy to a sexual hunger.
I know it's quite a bit more complicated in the men's department, and I can't imagine having to deal with actual physical and visible performance issues. The Stim's are always a possibility, although you have stated in the past that Stim's, Ritalin in particular are a little too activating for your comfort???
Maybe Bupropion could add something, but I don't have a handle on the pharmo-dynamics of Wellbutrin, so I'm not sure what the exact applied individual logic is for utilizing it. What activities in Amisulpride and Adrafinil seem to cause the sexual difficulties? I've tried to keep current with all the wonderfully detailed info you've been posting but still don't comprehend all of these dynamics. I wish I had more to offer than luck and well wishes :-)
My thoughts are with you John!!!
dove
Posted by SLS on November 7, 2000, at 14:03:50
In reply to Need Some Drug Advice, posted by JohnL on November 7, 2000, at 4:27:33
Hi John,
> I need some help from my drug expert buddies out there.
>
> As everyone knows, I've done extremely well with low doses of Amisulpride+Adrafinil. I have one and only one side effect. But it's a bad one. Impotence.Why don't you give trazodone a try. Perhaps priapism isn't such a bad thing. You'll have to figure out some way to harness yourself between encounters, though. :-)
Actually, trazodone had been looked at for the treatment of impotence several times. It is worthless.
I have nothing to add to what I'm sure you already know. If apomorphine were available, it would have been interesting to try.
Good luck.
- Scott
Posted by Anna P. on November 7, 2000, at 14:21:43
In reply to Need Some Drug Advice, posted by JohnL on November 7, 2000, at 4:27:33
>
Could you try Sulpiride? For me it worked without
the sexual side effects.Anna P.
I need some help from my drug expert buddies out there.
>
> As everyone knows, I've done extremely well with low doses of Amisulpride+Adrafinil. I have one and only one side effect. But it's a bad one. Impotence.
>
> My pdoc retired. My GP moved away. Out in the cold, I had to find a new doc. I found one. I spent no time researching, I just sought the GP nearest to where I live. As it turns out, I got lucky, he's awesome. We discussed everything in detail, but still I need feedback from folks here at this board.
>
> His first suggestion was to try Viagra. I didn't like Viagra, but may have to revisit that option if all else fails.
>
> His second suggestion was to try me on one week of extended release Ritalin instead of Adrafinil, and then one week of Adderall. I couldn't believe it! Has this guy been reading Jensen stuff, or what?
>
> If these trials don't turn out well for whatever reason, then next he would have me restart the Adrafinil, and possibly try an alpha-1 antagonist to counteract it on an as-needed basis. I think he mentioned Prazosin. This maybe in combination with Viagra.
>
> In the end, if all these things fail, then he would have me consider longterm trial of Wellbutrin in addition to my other drugs.
>
> My question to you all is this...Do you think an alpha-1 antagonist like Prazosin could counteract the agonist activity of Adrafinil? I read one clinical study where Prazosin did do that to Provigil. But I also wonder if that is something that could happen right away, or whether it is something that would take time. I mean, Adrafinil takes time to work. From what I've read about Prazosin, it takes time too. I wonder if it would have any effect on an as-needed basis.
>
> I also noticed there is a drug called Nicergoline that is also an alpha-1 antagonist which is supposedly much more competitively powerful in site binding than Prazosin.
>
> Anyway, I was surprised to find a doc who had no problem with my current meds, and who is willing to tweek out the details. A soft lifeless genital organ is my concern. He says this soft relaxed muscle condition is common with any alpha or beta agonist. I would welcome any and all feedback from anyone.
> Thank you,
> John
Posted by JahL on November 7, 2000, at 14:33:17
In reply to Re: Need Some Drug Advice, posted by Anna P. on November 7, 2000, at 14:21:43
> >
>
> Could you try Sulpiride? For me it worked without
> the sexual side effects.
>
> Anna P.I can second this, though from a male perspective. I actually find Sulpiride to be more efficacious than Amisulpride.
Jah.
Posted by anita on November 8, 2000, at 18:33:32
In reply to Re: Need Some Drug Advice » JohnL, posted by Maniz on November 7, 2000, at 8:22:25
Hi John,
Stimulation of 5HT2A receptors along the spinal cord can cause sexual dysfunction. So you could try meds with 5HT2A antagonism, like Remeron, Serzone, trazadone, risperidone, or olanzapine. These would probably interfere with the meds you are already taking, tho, and I haven't heard of them improving sexual function much in general.
Gingko biloba or yohimbe might be worth a try.
anita
Posted by Seamus2 on November 8, 2000, at 21:15:46
In reply to Need Some Drug Advice, posted by JohnL on November 7, 2000, at 4:27:33
> As everyone knows, I've done extremely well with low doses of Amisulpride+Adrafinil. I have one and only one side effect. But it's a bad one. Impotence < <
John,
I remembered the other prolactin antagonist: pergolide.
After a couple days on the 2mg/day doxazosin, confounded by increasing Amisulpride 100% to 100 mg/day, I'm limper than a wet, over-boiled noodle. Since I've been on the doxazosin w/out the amisulpride w/out this effect, I can only assume it's the amisulpride causing the impotency.
My guess is still hyperprolactinemia from the Amisulpride; not a-1 agonism from the adrafanil.
Do you have any signs of gynecomastia?
Regards,
Seamus
Posted by michael on November 8, 2000, at 21:56:56
In reply to Need Some Drug Advice, posted by JohnL on November 7, 2000, at 4:27:33
Hey John,
The last piece of the puzzle...
For what it's worth - as I've mentioned before - bromocriptine seemed to help with that. I think 5mg once or twice a day, seemed to take effect pretty quickly... (got the idea from the "tips" section)
I also noted that in the "tips" section, one doctor mentioned granisetron, a 5HT3 antagonsist was helpful - however, it's very expensive. (I think it's to treat nauseau (sp?))
In the same vein, perhaps odansetron, which I think is similar, might be an option. (kind of guessing here, haven't done any research on this lately) I believe andrew mention it a while ago, and that it had mildly mentally energizing effect...? I think that it too is generally really expensive, but it can be found abroad for a fairly reasonable/inexpensive price.
Those are my best ideas. Tried yohimbe - the otc stuff. It was definitely helpful for that particular symptom/side effect, but was accompanied by a really "edgy" feeling...
Good luck, and I hope you'll pass along the "right" answer when you determine what it is!
michael
> I need some help from my drug expert buddies out there.
>
> As everyone knows, I've done extremely well with low doses of Amisulpride+Adrafinil. I have one and only one side effect. But it's a bad one. Impotence.
>
> My pdoc retired. My GP moved away. Out in the cold, I had to find a new doc. I found one. I spent no time researching, I just sought the GP nearest to where I live. As it turns out, I got lucky, he's awesome. We discussed everything in detail, but still I need feedback from folks here at this board.
>
> His first suggestion was to try Viagra. I didn't like Viagra, but may have to revisit that option if all else fails.
>
> His second suggestion was to try me on one week of extended release Ritalin instead of Adrafinil, and then one week of Adderall. I couldn't believe it! Has this guy been reading Jensen stuff, or what?
>
> If these trials don't turn out well for whatever reason, then next he would have me restart the Adrafinil, and possibly try an alpha-1 antagonist to counteract it on an as-needed basis. I think he mentioned Prazosin. This maybe in combination with Viagra.
>
> In the end, if all these things fail, then he would have me consider longterm trial of Wellbutrin in addition to my other drugs.
>
> My question to you all is this...Do you think an alpha-1 antagonist like Prazosin could counteract the agonist activity of Adrafinil? I read one clinical study where Prazosin did do that to Provigil. But I also wonder if that is something that could happen right away, or whether it is something that would take time. I mean, Adrafinil takes time to work. From what I've read about Prazosin, it takes time too. I wonder if it would have any effect on an as-needed basis.
>
> I also noticed there is a drug called Nicergoline that is also an alpha-1 antagonist which is supposedly much more competitively powerful in site binding than Prazosin.
>
> Anyway, I was surprised to find a doc who had no problem with my current meds, and who is willing to tweek out the details. A soft lifeless genital organ is my concern. He says this soft relaxed muscle condition is common with any alpha or beta agonist. I would welcome any and all feedback from anyone.
> Thank you,
> John
Posted by Brandon on November 8, 2000, at 22:10:56
In reply to Re: Need Some Drug Advice » JohnL, posted by michael on November 8, 2000, at 21:56:56
What about low dose selegiline. Say 2.5-5mgs. every day or every other day. I believe Andrewb is taking a selegiline amisulpride combo, maybe he can comment on this.
Posted by michael on November 8, 2000, at 22:24:34
In reply to Re: Need Some Drug Advice » JohnL, posted by michael on November 8, 2000, at 21:56:56
sorry - it's spelled ondansetron - here's a quick blurb (hope it's not too long):
Description: Ondansetron is an oral and parenteral antiemetic agent. It is the first selective serotonin blocking agent to be marketed. It is similar to granisetron, which was marketed in 1994. Ondansetron is an extremely safe and highly effective antiemetic that has greatly improved the ability to give chemotherapy. The quality of life of patients has been tremendously better with ondansetron than with older, traditional antiemetics. When administered at optimal doses, ondansetron and other selective serotonin antagonists (e.g., granisetron) are equally effective. Ondansetron has occasionally been utilized for the treatment of hyperemesis gravidarum refractory to other treatments. Novel investigational uses of ondansetron include treatment of gastrointestinal motility disorders and drug dependence. Ondansetron was originally approved for the treatment of chemotherapy-induced nausea/vomiting by the FDA in January 1991 and oral dosage forms were approved for the treatment of post-operative nausea/vomiting in April 1995. An orally disentegrating tablet, Zofran ODT®, does not require water to aid in swallowing, and was approved by the FDA in February 1999.
Mechanism of Action: Ondansetron may have central and/or peripheral action. Ondansetron preferentially blocks the serotonin 5-HT3 receptors. 5-HT3 receptors are found centrally in the chemoreceptor trigger zone and peripherally at vagal nerve terminals in the intestines. Whether the action of ondansetron is mediated centrally, peripherally, or a combination of both remains to be determined. Emesis during chemotherapy and radiation therapy appears to be associated with the release of serotonin from enterochromaffin cells in the small intestine. Blocking these nerve endings in the intestines prevents signals to the central nervous system. Ondansetron is also a weak antagonist of the 5-HT4 receptor, and may bind to other serotonin receptors as well. Ondansetron has also been demonstrated to bind to the opioid µ receptor. The clinical implications of these actions is uncertain. Ondansetron has no dopamine-receptor blocking activity. Colonic transit time is slowed after multiple oral doses of ondansetron.
Pharmacokinetics: Ondansetron is administered orally and parenterally. Oral bioavailability of the tablets is 59%. The drug is also administered by IV infusion. Animal studies indicate that ondansetron has no teratogenic effects and that it is distributed into breast milk. Approximately 36% of an ondansetron dose is distributed into erythrocytes. The drug is about 70—76% bound to plasma protein. Ondansetron undergoes extensive metabolism, mainly by hydroxylation, followed by glucuronide or sulfate conjugation. For adults, the mean elimination half-life is 4 hours; patients under age 15 years show a shorter half-life of about 2.4 hours. Less than 5% of an intravenous dose is eliminated unchanged in the urine. The inactive metabolites are eliminated in the urine.
and granisetron:
Description: Granisetron is an oral and parenteral antiemetic agent. It is commonly used to offset nausea and vomiting from highly emetogenic cancer chemotherapy and its efficacy has recently been demonstrated in combination with dexamethasone.[572] Granisetron is similar to ondansetron in activity, efficacy, and adverse effects. Unlike ondansetron, it is not approved for postoperative emesis. Despite its effectiveness, granisetron is not recommended for the routine treatment of nausea due to its significant cost relative to other anti-nauseants. Granisetron injection was approved by the FDA on December 29, 1993. The oral dosage form was subsequently approved March 20, 1995 and has been shown to be as effective as IV ondansetron for chemotherapy-induced nausea and vomiting. In July 1999, the FDA approved granisetron for the prevention of radiation induced nausea and vomiting.
Mechanism of Action: Granisetron may have central and peripheral actions. Granisetron selectively blocks type 3 serotonin (5-HT3) receptors. 5-HT3 receptors are found centrally in the chemoreceptor trigger zone and peripherally at vagal nerve terminals in the intestines. Whether the action of granisetron is mediated centrally, peripherally, or a combination of both remains to be determined. Its affinity for 5-HT3 receptors is 4,000—40,000 times higher than for other serotonin receptors.[488] Emesis during chemotherapy appears to be associated with the release of serotonin from enterochromaffin cells in the small intestine. Blocking these nerve endings in the intestines prevents signals to the central nervous system. Granisetron may antagonize the effects of serotonin on the cholinergic neurons of the colon, slowing colonic transit time.
Pharmacokinetics: Granisetron is administered orally and parenterally. The pharmacokinetics of granisetron are similar in pediatric and adult cancer patients when the volume of distribution and total clearance are adjusted for body weight. Granisetron distributes freely between plasma and erythrocytes. Coadministration with food decreases the AUC by about 5% and increases the Cmax by about 30% in nonfasted healthy volunteers. It is unknown whether granisetron crosses the placenta or is distributed into breast milk, but animal studies have revealed no teratogenic effects. Approximately 65% of the drug is protein bound.
Granisetron undergoes N-demethylation and oxidation in the liver. Because in vitro studies have shown that the primary route of metabolism of granisetron is inhibited by ketoconazole, the cytochrome P-450 system is probably a metabolic pathway of the drug. Animal studies indicate that the metabolites may have pharmacologic activity. The terminal half-life following IV administration is 9—12 hours in cancer patients and 5—7.7 hours in healthy individuals. Oral administration results in a half-life of 6.23 hours in normal volunteers; no data is available for the oral half-life in cancer patients. There is considerable interpatient variability in the clearance. Approximately 12% of a dose is eliminated unchanged in the urine. The metabolites are excreted in the urine (49%) and the feces (34%). Dosage adjustment in patients with renal or hepatic disease is not necessary.> Hey John,
>
> The last piece of the puzzle...
>
> For what it's worth - as I've mentioned before - bromocriptine seemed to help with that. I think 5mg once or twice a day, seemed to take effect pretty quickly... (got the idea from the "tips" section)
>
> I also noted that in the "tips" section, one doctor mentioned granisetron, a 5HT3 antagonsist was helpful - however, it's very expensive. (I think it's to treat nauseau (sp?))
>
> In the same vein, perhaps odansetron, which I think is similar, might be an option. (kind of guessing here, haven't done any research on this lately) I believe andrew mention it a while ago, and that it had mildly mentally energizing effect...? I think that it too is generally really expensive, but it can be found abroad for a fairly reasonable/inexpensive price.
>
> Those are my best ideas. Tried yohimbe - the otc stuff. It was definitely helpful for that particular symptom/side effect, but was accompanied by a really "edgy" feeling...
>
> Good luck, and I hope you'll pass along the "right" answer when you determine what it is!
> michael
>
>
> > I need some help from my drug expert buddies out there.
> >
> > As everyone knows, I've done extremely well with low doses of Amisulpride+Adrafinil. I have one and only one side effect. But it's a bad one. Impotence.
> >
> > My pdoc retired. My GP moved away. Out in the cold, I had to find a new doc. I found one. I spent no time researching, I just sought the GP nearest to where I live. As it turns out, I got lucky, he's awesome. We discussed everything in detail, but still I need feedback from folks here at this board.
> >
> > His first suggestion was to try Viagra. I didn't like Viagra, but may have to revisit that option if all else fails.
> >
> > His second suggestion was to try me on one week of extended release Ritalin instead of Adrafinil, and then one week of Adderall. I couldn't believe it! Has this guy been reading Jensen stuff, or what?
> >
> > If these trials don't turn out well for whatever reason, then next he would have me restart the Adrafinil, and possibly try an alpha-1 antagonist to counteract it on an as-needed basis. I think he mentioned Prazosin. This maybe in combination with Viagra.
> >
> > In the end, if all these things fail, then he would have me consider longterm trial of Wellbutrin in addition to my other drugs.
> >
> > My question to you all is this...Do you think an alpha-1 antagonist like Prazosin could counteract the agonist activity of Adrafinil? I read one clinical study where Prazosin did do that to Provigil. But I also wonder if that is something that could happen right away, or whether it is something that would take time. I mean, Adrafinil takes time to work. From what I've read about Prazosin, it takes time too. I wonder if it would have any effect on an as-needed basis.
> >
> > I also noticed there is a drug called Nicergoline that is also an alpha-1 antagonist which is supposedly much more competitively powerful in site binding than Prazosin.
> >
> > Anyway, I was surprised to find a doc who had no problem with my current meds, and who is willing to tweek out the details. A soft lifeless genital organ is my concern. He says this soft relaxed muscle condition is common with any alpha or beta agonist. I would welcome any and all feedback from anyone.
> > Thank you,
> > John
Posted by kazoo on November 9, 2000, at 0:13:41
In reply to Need Some Drug Advice, posted by JohnL on November 7, 2000, at 4:27:33
> Impotence.
^^^^^^^^^^^
Good grief!
With all the experts in this group, you'd think someone would suggest the most obvious, most NATURAL
solution to this problem: DHEA (dehydro-epi-androsterone) ... 8 bucks for 60 tablets, 25 mgs. each, found in
any natural food or drug store ... take 25 mgs in the a.m. to start with for a week or so, and this can be increased
to two.You will not get instant results as with VIAGRA (although I heard of cases otherwise), but give it a couple of days.
You'll have more lead than you'll know what to do with. This is what I use and it works
well. Sorry, my dear Ladies, this stuff ain't for you, unless, of course, you have a penchant for body
hair.Also, I do NOT recommend any of those other freaky drugs as suggested.
SERZONE for sex? Heavens to murgatroid: that's an exercise in necrophilia.Greetz to JohnL ... may the schvantz be with you.
kazoo
Posted by dove on November 9, 2000, at 11:04:41
In reply to Re: Need Some Drug Advice, posted by kazoo on November 9, 2000, at 0:13:41
> SERZONE for sex? Heavens to murgatroid: that's an exercise in necrophilia.
>
> kazooI disagree, solely based on personal experience. I do *not* recommend taking Serzone (Nefazodone) at full therapeutic levels, nor do I think that it should be taken daily. Small doses, an hour ahead of time or so, were my exact thoughts. I know that my reactions to meds seem to greatly vary from most people's, a personal example is my positive reaction to Amitriptyline for losing the anorgasmia; so that is a legitimate concern and aspect in my opinion.
And though most of us have gone the OTC route at some point, some have found relief while others have not. John knows where to look for OTC meds, he's well studied and brave :-) I think he was wondering outloud as to what has worked for other people personally? If I'm interpreting the question incorrectly, please feel free to correct me! Your thoughts and advice are very interesting, just one question, when you wrote about women getting hairy, was this in reference to Viagra or DHEA? (I have tried DHEA with no positive results what-so-ever, but am still interested in how it works for other people.)
Good and glad to see you kazoo :-)
dove
Posted by Mark H. on November 9, 2000, at 21:25:52
In reply to Need Some Drug Advice, posted by JohnL on November 7, 2000, at 4:27:33
John,
I assume you've tried dosage timing to create brief (less than 24 hour) drug holidays to accommodate sexual activity right before you have to take your next dose? And would you mind saying what your objections were to Viagra?
I wouldn't presume to offer you any advice on meds, oh learned one!!
Best wishes,
Mark H.
Posted by AndrewB on November 11, 2000, at 9:53:53
In reply to Need Some Drug Advice, posted by JohnL on November 7, 2000, at 4:27:33
John,
I am on selegiline, amisulpride, and adderall now. Another person is on this same combo and doing very well, as am I.
My erection is less hard than it used to be (still have fairly good sexual function though). I did not notice this effect when I started taking amisulpride but only after I added on reboxetine. I don't take reboxetine anymore but some of its effects remain; genital tightening in resting state (cold water syndrome!), retrograde ejaculation, and a less hard erection. I am on 75mgs of amisulpride now vs. 50mgs. before, so maybe that has made a difference.
When I use Viagra, my erection is again as hard as ever.
Prazosin when I tried it made me tired and didn't help sexual function. It works within an hour or two.
Yohimbine improved sexual funtion but was accompanied by increased heartrate, sweating and headache.
Selegiline plus a stimulant is a possible substitute for adrafinil.
If problem is with high prolactin levels you can try adding on Mirapex (pramipexole). It lowers prolactin levels. I've taken Mirapex with amisulpride and it does not counteract amisulpride’s mood enhancing effects.
AndrewB
Posted by JohnB on November 11, 2000, at 23:12:36
In reply to Re: Need Some Drug Advice, posted by AndrewB on November 11, 2000, at 9:53:53
Andrew.
Sorry to hear that an NRI such as Rebox causes sexual problems. Since the reduction in cholinergic tone is indirect, ie., from increased sympathetic tone, wouldn't the symptoms be milder? Also, how long did you take the Rebox?
Posted by JohnB on November 13, 2000, at 15:17:28
In reply to Re: Rebox » AndrewB, posted by JohnB on November 11, 2000, at 23:12:36
I read that someone claimed that Flomax, an alpha adrenergic medication used to relieve the symptoms of an enlarged prostate, eased his AD induced sex problems. Anybody have any comments on this?
Posted by JohnB on November 13, 2000, at 15:38:16
In reply to Re: Flomax??, posted by JohnB on November 13, 2000, at 15:17:28
To be more specific, Flomax is an alpha-adrenergic blocking agent.
Posted by Anna P. on November 14, 2000, at 13:37:39
In reply to Re: Rebox » AndrewB, posted by JohnB on November 11, 2000, at 23:12:36
> Andrew.
>
> Sorry to hear that an NRI such as Rebox causes sexual problems. Since the reduction in cholinergic tone is indirect, ie., from increased sympathetic tone, wouldn't the symptoms be milder? Also, how long did you take the Rebox?In my case, Rebox didn't cause sexual dysfunction, unfortunately, it stopped working.
Anna P.
Posted by michael on November 15, 2000, at 21:17:09
In reply to Re: Flomax??, posted by JohnB on November 13, 2000, at 15:38:16
So would this imply that it would "counter-act", in essence, the effects of adrafinil? Since this (of course, I may be mistaken on this) is the is the supposed mechanism of adrafinil?
Just wondering... anyone feel like they have a handle on this...?
Thanks for any thoughts....
michael
> To be more specific, Flomax is an alpha-adrenergic blocking agent.
This is the end of the thread.
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