Shown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by Andre Allard on October 31, 2000, at 12:42:32
I know the maximum recommended dosage of effexor is 225mg/day and maybe even 375mg/day. I have heard some cases where patients are taking up to 600mg/day. What are some of the high dosages you guys have been on?
Posted by noa on October 31, 2000, at 15:44:57
In reply to MAX DOSAGES OF EFFEXOR, posted by Andre Allard on October 31, 2000, at 12:42:32
I have been up to 375 of effexor xr, but for me it was too activating, side effects such as muscle twitches, restlessness, insomnia, etc. Now I take 300 effexor xr, but also take 300 of Serzone. Actually, I just started taking 325 of serzone because some of the sleep problems have crept back (restless legs causing insomnia). I slept a whole lot better on the first night of this increased dose of serzone.
Posted by shar on October 31, 2000, at 16:42:09
In reply to Re: MAX DOSAGES OF EFFEXOR, posted by noa on October 31, 2000, at 15:44:57
I'm on 300 Effexor XR and supposed to be doing 300 of Wellbutrin, but usually only do 200 Wellbutrin because I forget the third pill in the afternoon.
Shar
> I have been up to 375 of effexor xr, but for me it was too activating, side effects such as muscle twitches, restlessness, insomnia, etc. Now I take 300 effexor xr, but also take 300 of Serzone. Actually, I just started taking 325 of serzone because some of the sleep problems have crept back (restless legs causing insomnia). I slept a whole lot better on the first night of this increased dose of serzone.
Posted by maribeth on October 31, 2000, at 18:43:32
In reply to Re: MAX DOSAGES OF EFFEXOR, posted by shar on October 31, 2000, at 16:42:09
> I'm on 300 Effexor XR and supposed to be doing 300 of Wellbutrin, but usually only do 200 Wellbutrin because I forget the third pill in the afternoon.
>
> Shar
>
>
> > I have been up to 375 of effexor xr, but for me it was too activating, side effects such as muscle twitches, restlessness, insomnia, etc. Now I take 300 effexor xr, but also take 300 of Serzone. Actually, I just started taking 325 of serzone because some of the sleep problems have crept back (restless legs causing insomnia). I slept a whole lot better on the first night of this increased dose of serzone.I have been on 300mgm of Effexor XR for about nine months. I also take a total of
300 mgm of Seroquel a day (in three doses) the "restless legs"(which I call my happy feet
are the only negative thing I have found -- so far the Effexor is the best AD I have
ever ben on. I never experienced any energizing,leg cramping
or other problems. The worst thing is that some my "happy feet wake my
husband up and then I wind up in the guest room!
Oh, I forgot the weight gain -- I really would like to lose the
thirty pounds I gained on Zyprexa --but I think the Effexor is preventing thzt. Will
the recently started Topomax help? Maribeth
Posted by allisonm on October 31, 2000, at 19:35:28
In reply to Re: MAX DOSAGES OF EFFEXOR, posted by maribeth on October 31, 2000, at 18:43:32
Andre,
How are you doing?
Posted by quilter on October 31, 2000, at 23:53:11
In reply to Re: MAX DOSAGES OF EFFEXOR, posted by allisonm on October 31, 2000, at 19:35:28
I take 375 mg of Effexor xr, along with a whole bunch of other meds. I can't tell what to blame my mess of side effects on at this point. Sigh
Quilter
Posted by tenuous on November 1, 2000, at 5:20:52
In reply to Re: MAX DOSAGES OF EFFEXOR, posted by maribeth on October 31, 2000, at 18:43:32
Just wondering if "restless legs" is when you find yourself bouncing your leg up and down off your toes whenever you sit down?
Posted by Noa on November 1, 2000, at 9:43:00
In reply to Q? restless legs=leg bouncing?, posted by tenuous on November 1, 2000, at 5:20:52
I sometimes do that, but for me it is more when I get into bed, I cannot suppress the need to move my legs around a lot--both shaking and moving back and forth, etc.
Posted by danf on November 1, 2000, at 14:12:51
In reply to Re: Q? restless legs=leg bouncing?, posted by Noa on November 1, 2000, at 9:43:00
the bouncing of the leg when up on toes is a sign of hyper reflexia, it usually goes along with muscle twitches, but they are not exactly the same thing.
It is a self sustaining reflex action.
myoclonic twitches are a sign of an excitable muscle unit or myoneural junction.
Mg helps some folks by decreasing 'nerve' or reflex excitability. It also calms excitable muscle membranes.
Posted by Cindy W on November 1, 2000, at 20:11:05
In reply to MAX DOSAGES OF EFFEXOR, posted by Andre Allard on October 31, 2000, at 12:42:32
> I know the maximum recommended dosage of effexor is 225mg/day and maybe even 375mg/day. I have heard some cases where patients are taking up to 600mg/day. What are some of the high dosages you guys have been on?
Andre, I'm taking 375 mg/day for depression and OCD, and have found it helpful. --Cindy W
Posted by Sunnely on November 2, 2000, at 0:42:21
In reply to Q? restless legs=leg bouncing?, posted by tenuous on November 1, 2000, at 5:20:52
> Just wondering if "restless legs" is when you find yourself bouncing your leg up and down off your toes whenever you sit down?
Hi Tenuous,
Another possibility is "akathisia." Both antipsychotics and antidepressants can cause this condition. Incidentally, the word "akathisia" came from the Greek word which means "not to sit"; "a" = absence and "kathis" = sitting still.
The motor restlessness in drug-induced akathisia predominantly involves the legs and feet, less commonly arms and trunk. On the other hand, motor restlessness in restless legs syndrome (RLS) is restricted to the legs, in most cases. Abnormal sensations in legs such as "pins and needles," "creeping and crawling," "aching," "burning," or "coldness" are usually absent in drug-induced akathisia, whereas they may be present in RLS. Myoclonic jerks are uncommon in drug-induced akathisia, but common in RLS (e.g., repetitive flexing of the hips, knees, ankles, and toes). Insomnia is uncommon (mild if present) with drug-induced akathisia but common and often severe with RLS (more number of awakenings; decreased sleep efficiency; prolonged sleep onset latencies; prolonged REM onset latencies; decreased in REM sleep). There is no diurnal pattern with the motor restlessness in drug-induced akathisia (less severe at night), whereas these symptoms are usually worse or exclusively in the evenings in RLS. Motor restlessness is worse on standing (leads to pacing, body rocking, marching-in-place, leg jiggling), with some relief on lying in drug-induced akathisia, whereas it is worse on lying in RLS. Motor restlessness may begin anytime after administration of offending drug, whereas with RLS, may begin in childhood to senescence, often progressive (severe after 50 years of age), but there may be spontaneous remissions. There is usually no family history in drug-induced akathisia, whereas this has been reported with RLS (autosomal dominant).
Posted by tenuous on November 2, 2000, at 9:38:47
In reply to Re: Q? restless legs=leg bouncing? » tenuous, posted by Sunnely on November 2, 2000, at 0:42:21
> The motor restlessness in drug-induced akathisia predominantly involves the legs and feet, less commonly arms and trunk. On the other hand, motor restlessness in restless legs syndrome (RLS) is restricted to the legs, in most cases. Abnormal sensations in legs such as "pins and needles," "creeping and crawling," "aching," "burning," or "coldness" are usually absent in drug-induced akathisia, whereas they may be present in RLS. Myoclonic jerks are uncommon in drug-induced akathisia, but common in RLS (e.g., repetitive flexing of the hips, knees, ankles, and toes). Insomnia is uncommon (mild if present) with drug-induced akathisia but common and often severe with RLS (more number of awakenings; decreased sleep efficiency; prolonged sleep onset latencies; prolonged REM onset latencies; decreased in REM sleep). There is no diurnal pattern with the motor restlessness in drug-induced akathisia (less severe at night), whereas these symptoms are usually worse or exclusively in the evenings in RLS. Motor restlessness is worse on standing (leads to pacing, body rocking, marching-in-place, leg jiggling), with some relief on lying in drug-induced akathisia, whereas it is worse on lying in RLS. Motor restlessness may begin anytime after administration of offending drug, whereas with RLS, may begin in childhood to senescence, often progressive (severe after 50 years of age), but there may be spontaneous remissions. There is usually no family history in drug-induced akathisia, whereas this has been reported with RLS (autosomal dominant).Oh goody, I match the symptoms of RLS now too! This is so predominant in my family that we named it ourselves ("The < familyname > Jitter") and everybody laughs about it when we spot someone else doing it at family gatherings! I'm unfamiliar with the progressive aspect of it though. Anyone know what that might entail? Noone has ever said anything about it getting worse with age; we're usually too preoccupied with our memory losses!
Posted by noa on November 2, 2000, at 10:16:45
In reply to Re: Q? restless legs=leg bouncing? thanks everyone, posted by tenuous on November 2, 2000, at 9:38:47
That is interesting-that it runs in families. I don't have familial restless legs syndrome, but have resteless legs as a side effect of effexor, in addition to myoclonus (not just in legs though). My restless legs is less of the bouncing up and down and more of a side to side, ankle shake and also, in bed, a back and forth, bend at the knee thing, like kicking. But sometimes it does show up as the bouncing thing.
Posted by AndrewB on November 3, 2000, at 1:18:38
In reply to Re: Q? restless legs=leg bouncing? thanks everyone, posted by noa on November 2, 2000, at 10:16:45
Pramipexle (Mirapex) as well as other drugs have been used effectively to deal with RLS.
AndrewB
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