Shown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by AndrewB on September 7, 2000, at 12:31:38
I haven't heard from either of you for awhile. How are things going?
Best wishes,
AndrewB
Posted by Peter S on September 7, 2000, at 20:39:51
In reply to Peter S, S.D.- How are you doing?, posted by AndrewB on September 7, 2000, at 12:31:38
Hey Andrew,
Thanks for the inquiry- I've been doing better for the last 2 weeks or so. It seems to be related to adding SAM-E to my regimen of Nardil and Lithium. The Nardil was pooping out on me- I have actually reduced the dose down to 45 mg and the Li to 600mg and I'm still doing good.
Of course I am also taking Vitamin B12 and Folic Acid with the SAM-E.
Anyway I'm crossing my fingers that this will last and I hope to start phasing out the Nardil all together at some point.
I hope you are doing as well as I am- how are things?
Peter S.
> I haven't heard from either of you for awhile. How are things going?
>
> Best wishes,
>
> AndrewB
Posted by AndrewB on September 7, 2000, at 21:45:14
In reply to SAM-E appears to be working, posted by Peter S on September 7, 2000, at 20:39:51
Peter,
I hope that SAMe is the thing that you needed. Keep us posted.
I am doing really, really well; good mood, confident, good energy and motivation. I hope this is here to stay.
When compiling the amisulpride mini-survey I was reminded that you were one of the ones who didn't respond to amisulpride. Were you taking Nardil at the time? I thought that you had the perfect profile for someone that would respond; dysthymic, having social anxiety, and having responded to Nardil (whose effectiveness is in part due to dopaminergic action).
An idea keeps going through my head that some people may not respond to amisulpride yet still have D2/D3 receptor dysfunction. Maybe somehow the amisulpride doesn't work for them because it isn't able for some reason to antagonize the pre-synaptic receptors.
However, even when amisulpride fails to work, maybe another drug that works on the D2/D3 receptors may work.
I thinking of the drug Mirapex (pramipexole). It, like amisulpride, acts on the D2/D3 receptors, but it works by a very different mode of action; it is a post-synaptic agonist not a pre-synaptic antagonist like amisulpride.
The one major study done with Mirapex showed it to be quite effective for depression. When I took it I found the side effect to be mild and transient.
If you want to consider taking Mirapex, I'll be glad to send you more information on it.
AndrewB
Posted by Peter S on September 8, 2000, at 0:40:58
In reply to Re: SAM-E appears to be working, posted by AndrewB on September 7, 2000, at 21:45:14
Andrew,
Thanks for the idea; I will definitely keep it in mind if this regimen doesn't work out. Where and how do you get Mirapex?
Peter
> Peter,
>
> I hope that SAMe is the thing that you needed. Keep us posted.
>
> I am doing really, really well; good mood, confident, good energy and motivation. I hope this is here to stay.
>
> When compiling the amisulpride mini-survey I was reminded that you were one of the ones who didn't respond to amisulpride. Were you taking Nardil at the time? I thought that you had the perfect profile for someone that would respond; dysthymic, having social anxiety, and having responded to Nardil (whose effectiveness is in part due to dopaminergic action).
>
> An idea keeps going through my head that some people may not respond to amisulpride yet still have D2/D3 receptor dysfunction. Maybe somehow the amisulpride doesn't work for them because it isn't able for some reason to antagonize the pre-synaptic receptors.
>
> However, even when amisulpride fails to work, maybe another drug that works on the D2/D3 receptors may work.
>
> I thinking of the drug Mirapex (pramipexole). It, like amisulpride, acts on the D2/D3 receptors, but it works by a very different mode of action; it is a post-synaptic agonist not a pre-synaptic antagonist like amisulpride.
>
> The one major study done with Mirapex showed it to be quite effective for depression. When I took it I found the side effect to be mild and transient.
>
> If you want to consider taking Mirapex, I'll be glad to send you more information on it.
>
> AndrewB
Posted by AndrewB on September 8, 2000, at 9:08:20
In reply to Re: SAM-E appears to be working, posted by Peter S on September 8, 2000, at 0:40:58
Peter,
Mirapex can be obtained with a prescription from your doctor. It is mainly used for Parkinsons.
AndrewB
Posted by S.D. on September 25, 2000, at 2:28:55
In reply to Peter S, S.D.- How are you doing?, posted by AndrewB on September 7, 2000, at 12:31:38
Things could be better. My motivation is way low, can't get me stuff together to stay on track with my 'plan of action'. May need to be back on antidepressant - no perfect choices there. Need to get back to full time work soon I think, to have forced discipline and motivation and to feel connected to the world again. Gonna concentrate on the highest priorities and try to get full time temp work in 6 weeks. If the temp/contract work is good, it gives me luxury of time to complete some more things (energy permitting, a big if) and consider direct employment without stressing about it.
Well, the revised plan is now in writing for the world to see, so I guess I'd better get it the hell done.
S.D.
This is the end of the thread.
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