Shown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by dj on August 1, 2000, at 10:46:08
My naturopath, who also does research for Sisu (http://www.sisuhealth.com/)is very thoughtful and careful when he makes recommendations to me and cites products other than the one's Sisu manufactures.
He's always been a big fan of standardized Siberian ginsing as a gradual energy booster and system balancer. Recently, when describing my at-times reaction to intense stress (tightening, tiring, lack of mental acuity) to him he recommended P5P which I had never heard of before. I've just picked some up and am curious if anyone else has any experience with it or exposure to it.
I did a quick on-line search and found bits and pieces of info. on it. According to one web-site: "The biologically active form of vitamin B-6 is ready to act with no conversions! Pyridoxal-5-Phosphate is a useful supplement for people with defects in metabolic conversions." Okay, whatever...
I found a bit more on the website for Priscilla Slagle, MD who is the author of a book called: "The Way Up From Down" (http://www.thewayup.com/) which focuses on B Vitamins and a range of Amino Acid treatments, far too many compounds listed for my non-chemistry literate mind.
On her website under P5P she notes, along with many other things that: "Supplementation increases the production of serotonin, norepinephrine, GABA, dopamine, & other neurotransmitters." and cites it as essential in any natural anti-depressant regime.
Another website (http://intelegen.com/nutrients/pyridoxal5phosphate.htm)links it with treating heart problems and dealing with "Homocysteine" which is something the SAMe literature talks about...
Not sure what to make of all of this and curious if anyone has any insights they would care to share, gained from usage or literature review. If the latter maybe someone can translate what they know about it into plain english and not pseudo-science, which some of the above may or may not be.
Any and all insights on this appreciated.
Sincerely,
dj
Posted by dj on August 1, 2000, at 23:27:51
In reply to P5P, Siberian Ginsing and The Way UP????, posted by dj on August 1, 2000, at 10:46:08
Any of you pharmo-informed have any insights you'd care to share on my prior notes and query about P5P...
Posted by shar on August 2, 2000, at 0:56:57
In reply to P5P, Siberian Ginsing and The Way UP????, posted by dj on August 1, 2000, at 10:46:08
When I visited the naturopath, he recommended P5P and said that I didn't process the regular B6 very well. I still take it (really sort of on and off) and have never noticed any positive effect from it.
I take a multi, P5P, CoQ10, Calcium, some other B (B12?) sublingually, and I think that's all. I always try to purchase the wheat free, "healthy" variety. I never feel better or worse when I take them, but I am concerned about my vitamin levels (or whatever they are).
Some people apparently respond very well to B's.
Good luck,
Shar
> My naturopath, who also does research for Sisu (http://www.sisuhealth.com/)is very thoughtful and careful when he makes recommendations to me and cites products other than the one's Sisu manufactures.
>
> He's always been a big fan of standardized Siberian ginsing as a gradual energy booster and system balancer. Recently, when describing my at-times reaction to intense stress (tightening, tiring, lack of mental acuity) to him he recommended P5P which I had never heard of before. I've just picked some up and am curious if anyone else has any experience with it or exposure to it.
>
> I did a quick on-line search and found bits and pieces of info. on it. According to one web-site: "The biologically active form of vitamin B-6 is ready to act with no conversions! Pyridoxal-5-Phosphate is a useful supplement for people with defects in metabolic conversions." Okay, whatever...
>
> I found a bit more on the website for Priscilla Slagle, MD who is the author of a book called: "The Way Up From Down" (http://www.thewayup.com/) which focuses on B Vitamins and a range of Amino Acid treatments, far too many compounds listed for my non-chemistry literate mind.
>
> On her website under P5P she notes, along with many other things that: "Supplementation increases the production of serotonin, norepinephrine, GABA, dopamine, & other neurotransmitters." and cites it as essential in any natural anti-depressant regime.
>
> Another website (http://intelegen.com/nutrients/pyridoxal5phosphate.htm)links it with treating heart problems and dealing with "Homocysteine" which is something the SAMe literature talks about...
>
> Not sure what to make of all of this and curious if anyone has any insights they would care to share, gained from usage or literature review. If the latter maybe someone can translate what they know about it into plain english and not pseudo-science, which some of the above may or may not be.
>
> Any and all insights on this appreciated.
>
> Sincerely,
>
> dj
Posted by CarolAnn on August 2, 2000, at 8:09:29
In reply to P5P, Siberian Ginsing and The Way UP????, posted by dj on August 1, 2000, at 10:46:08
dj, this is very interesting I've never heard of P5P and I'm usually up on the latest 'natural' energy booster info, because of my constant non-medically caused fatigue. Is it sold in regular health stores?
Also, I've tried several brands of Siberian ginseng(including ginsana, which someone here recommended), each for 4 to 6 months at a time, and never gotten any energy boost(or other effect) at all, just wondering if some of this 'natural' stuff has more of a placebo effect?
I'm sorry I haven't posted to you before now, but I do read all your posts and am very glad you're back! CarolAnn
Posted by dj on August 2, 2000, at 12:01:39
In reply to Re: P5P, Siberian Ginsing and The Way UP???? » dj, posted by CarolAnn on August 2, 2000, at 8:09:29
Hi Carol Ann,
Nice to hear from you and nice to be back for awhile. Though my goal is spend less time here and more time doing and dealing with the things off-line that I need to. This is a support system, while I am spending too much time on-line and a good one, though not sufficient. It helps lots at times though, to read the posts and to do some of my own on-line pondering and attempting to make sense of it all...
I've tried Siberian Ginsing in the past and not sure whether it helped or not as I was doing a variety of things and still am expermenting. Often hard to sort the wheat from the chaff.
I had never heard of the P5P until my naturopath mentioned it. Just picked up some on Sunday and am trying it out along with Sisu B-Stress Select that includes 50 mgs. Siberian ginsing and some others B combos which I gather are supposed to balance out the P5P though I need to talk more with my naturopath as the combo I chose was slightly different from what he recommended.
Also trying some Sisu Ginsing Plus which has 100 mgs. Siberian Ginsing plus 300 mgs. Ashwaganda which is I believe a "tonifer" like S.G. and supposed to help with energy and systemic balance.
Been a stressful past few days and hard to say what the impact is of these and/or some of the unanticpated personal challenges I've been dealing with. Whatever the case I'm feeling pretty buzzed right now. Been up since 5 or so and also had a couple of cups of coffee but I think the above mix plus some ginsing tea is having a combined stimulatory effect, overall.
The challenge with herbal formulations is to ensure that your supplier is a good one. As for placeboe effect I think there is always that but these mixes can be helpful too. Just have to make sure you get a good one, and try it out for sufficient time. Like everything milage varies with the person, timing and circumstances.
Hope this is finding you well.
Sante!
dj
Posted by dj on August 2, 2000, at 13:14:38
In reply to Re: P5P, Siberian Ginsing and The Way UP????, posted by dj on August 2, 2000, at 12:01:39
My naturopath had recommended Vital Life's mix of P5P with magnesium to me because it was the only brand sold locally which he knew of to be pure P5P. When purchasing it I noted what I thought was a better deal and dosage from something called the AllergyResearchGroup and went for that...
Just spoke with my naturopath now and he pointed out that what I had purchased turns out to be a mix with a very small percentage of it being pure P5P which is supposed to be much more effective on stress relief than just B6, which it is the active form of, whatever that means...
Anyway, what I purchased is titled Pyridoxine P5P in the largest print on the front. In finer print on the back it notes the combo to be 91% as Pyridoxine Hydrochloride and 9% as Pyridoxal-5-Phospate, the latter being what I THOUGHT I was purchasing. So much for a bargain and for not having paid attention to the small print. : (
Sante!
dj
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