Shown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by JohnB on July 14, 2000, at 5:34:52
How's the adrafinal holding up? Any augmentors necessary? Also, was it ever cleared up as to whether those eye-drops were acurate predictors of adrafinal success? They seem to put me in a good frame of mind. --JB
Posted by AndrewB on July 14, 2000, at 20:29:07
In reply to Hey, JohnL, posted by JohnB on July 14, 2000, at 5:34:52
> How's the adrafinal holding up? Any augmentors necessary? Also, was it ever cleared up as to whether those eye-drops were acurate predictors of adrafinal success? They seem to put me in a good frame of mind. --JB
It doesn't seem to be clear whether adrafinil works via alpha1 andrenergic receptor stimulation and thus whether the naphazoline eye drops are predictive of success with adrafinil.
Posted by JohnB on July 15, 2000, at 4:25:13
In reply to Re: Hey, JohnL, posted by AndrewB on July 14, 2000, at 20:29:07
> It doesn't seem to be clear whether adrafinil works via alpha1 andrenergic receptor stimulation and thus whether the naphazoline eye drops are predictive of success with adrafinil.Thanks Andrew. Now when you were talking
about the naphazoline drops, you said they
might make you feel better. I seem to feel better,
but maybe it's placebo. Were you talking
from personal experience about
that response? From other doctors or from
studies? I'll go back and read your posts, but
it sounded like you personally had got a
response. Best Regards, --JB
Posted by JohnL on July 15, 2000, at 8:05:21
In reply to Hey, JohnL, posted by JohnB on July 14, 2000, at 5:34:52
> How's the adrafinal holding up? Any augmentors necessary? Also, was it ever cleared up as to whether those eye-drops were acurate predictors of adrafinal success? They seem to put me in a good frame of mind. --JB
John,
I'm doing fine. Not as well as before, yet. You see, me and my stupid ideas...I felt so much improved with Adrafinil, and yet it seems so tame, that I wasn't totally convinced it was the med doing it. I thought maybe it was just a spontaneous remission, or the late spring/early summer bounce. Or something. But certainly not Adrafinil. I mean, I can't feel it. No side effects. Can't be.So I challenged it. I stopped taking it. Three days later I had lost that cherished motivation. All my projects, activities, friends, hobbies seemed totally boring and meaningless. I didn't want to do anything anymore. I kind of dropped out of psychobabble for a while. But I figured it was my imagination. After a week, I was in bad shape. Depression full steam ahead.
So I started up Adrafinil again. It's been a 1 1/2 weeks. I feel about 80% better. If it's anything like the first time around, it'll take 3 or 4 weeks to hit 99%.
Augmentors? One a day of SJW (New Chapter brand 10% hyperforin), and about 5mg Remeron at bedtime.
As for the eye drops, I haven't a clue. Haven't tried that. Since I have responded well to Adrafinil, I might be a good test subject to test those eyedrops. There have been varying opinions on what exactly Adrafinil does. Word of mouth. Friend of friend. Theory. That kind of stuff. But for now I am most comfortable sticking with what the manufacturer has put into print. That is, alpha-1 noradrenergic agonism, and at higher doses release of serotonin and dopamine.
John
Posted by AndrewB on July 15, 2000, at 10:41:01
In reply to Re: Hey; to Andrew, posted by JohnB on July 15, 2000, at 4:25:13
Yes I've personally taken Naphazoline eyedrops and have gotten a strong response. It is like the one I get from reboxetine. I also have read reprots from two CFIDs doctors on the use of naphazoline.
Note, for myself and many others, tolerance for Naph.'s effects build up rapidly, so the effect that was there at the start may rapidly become impossible to replicate.
Naphazoline and reboxetine act on both central and periphereal alpha1 andrenergics receptors, thus such periphereal receptor stimulation symptoms like raised BP and increased sweating. Adrafinil, even it does have alpha1 agonism, may be just centrally acting. But it is the central action that I presume is responsible for the cognitive (and mood) effects of Naph.
AndrewB
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