Psycho-Babble Medication Thread 38732

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how to transform powder form to tablets form

Posted by Leong Khah Loon on June 29, 2000, at 14:47:36

hi all

I'm Loon from Malaysia. I'm one of the student from malaysia local University, if you all can help me, i would like to know information about transforming powder form to tablet form which the powder form is water soluble. when i punch out from the machine to the die the tablet form is there but i cant get the hardeness so i would like to have some advise from you all. Is that need any extra chemical added ???
Hopefully i can have some information from you all

Thank you very much
bye

Loon

 

Calling Cam W for some old compounding info

Posted by danf on June 29, 2000, at 16:42:57

In reply to how to transform powder form to tablets form, posted by Leong Khah Loon on June 29, 2000, at 14:47:36

Yes loon, you need a binder or maybe 2 ?

as to what to use ?

It will depend on the chemical you want to make into a pill.

sometimes sugars like fructose can be used. sucrose ( granulated white sugar from cane will NOT work ! )

You need to say what the chemical is. the binder has to be compatible & not cause degredation of the chemical.

perhaps Cam has a ref or 2. my pharmacology did not go into manuf methods.

 

Re: how to transform powder form to tablets form

Posted by Cam W. on June 29, 2000, at 16:55:40

In reply to how to transform powder form to tablets form, posted by Leong Khah Loon on June 29, 2000, at 14:47:36

Loon - Tablets do contain binders and excipients (filler) because the dose of drug we need is so small, that we have to add inert substances (eg. maltose) so the drug can be handled in a convenient way. Binders hold the tablet together, like glue (pack a tablet too tightly and it will go right through you with negligible absorption).

To tell you the truth, I hated making pills and suppositories in class. I wouldn't know how to begin to make a tablet. I do know which books to look in though.

Before I tell you where you look to fix your problem, why don't you ask your professor what you are doing wrong? This is second year Pharmacy stuff you are asking here. If you are formulating medicine or illicit chemicals without a licence, I really do not want to be abetting a criminal.

If you can give me a reasonalble reason why you are making this drug and what the drug is, I would be glad to answer your question.

- Cam W.

 

Thanks, Cam !

Posted by danf on June 29, 2000, at 17:14:51

In reply to Re: how to transform powder form to tablets form, posted by Cam W. on June 29, 2000, at 16:55:40

Those thoughts did occur, but guess I am too trusting.

Anyway, enjoy the cold North !

Has been warm in Florida today.

 

Re: how to transform powder form to tablets form

Posted by Leong Khah Loon on June 30, 2000, at 12:39:11

In reply to Re: how to transform powder form to tablets form, posted by Cam W. on June 29, 2000, at 16:55:40


Thanks Cam

This is one of my assignment title that my Prof ask. Coz he said that most probaly drugs are active so how to make it inactive such as in tablets form. and i really dont know, what the exact drugs is using coz my prof said so commonly that he mean most of the drugs is active, this Question come out accidently while my class diccussing other things, so i dont have more detail information about this.

i understand what u mean about drugs coz i also know drugs is very dangerous if they are misuse so if you cant give me futher information about drugs, is OK coz i understand your situation
anywhere thanks a lot for your information but i hope that you can help me

Thank You

 

Re: Calling Cam W for some old compounding info

Posted by Leong Khah Loon on June 30, 2000, at 13:02:20

In reply to Calling Cam W for some old compounding info, posted by danf on June 29, 2000, at 16:42:57

Thanks to u
danf and Cam

 

Re: how to transform powder form to tablets form

Posted by Cam W. on July 2, 2000, at 11:49:48

In reply to Re: how to transform powder form to tablets form , posted by Leong Khah Loon on June 30, 2000, at 12:39:11

Leong - I think what your prof meant by active and inactive drugs has to do with drug stability. The drug itself is active in solution (ie dissolved in blood plasma in it's ionized form) where it can act at a receptor. In tablet (or capsule) form the drug in solution is mixed with a substance that causes the drug to precipitate out of solution. Basically what you are doing is forming a "salt". A drug usually is more stable in a salt form.

An example of a simple salt is sodium chloride (NaCl - table salt). A solution of sodium (dissolved sodium hydroxide - NaOH - another salt) is mixed with hydrochloric acid (HCl) and sodium chloride (NaCl) and water (H2O) are formed. Or:

NaOH + HCL -> NaCl + HOH (or H20)

The combination of sodium and chloride are insoluble in water, so they turn to a solid when they combine. The same principle is used to turn drugs into solids (eg fluoxetine in powder form is the salt fluoxetine hydrochloride). These salts dissociate (or break apart) either in acidic solutions (stomach) or in basic solutions (small intestine) and then the active drug is absorbed.

Hope this is what you are looking for. - Cam

 

Thanks Cam

Posted by Leong Khah Loon on July 3, 2000, at 11:04:38

In reply to Re: how to transform powder form to tablets form , posted by Cam W. on July 2, 2000, at 11:49:48

Thanks Cam

i think thats what my prof want
if for experiment purpose
that mean a DRUGS (named X )add in sugar
(eg. fructose or maltose) then go through a process then become a salt (or tablet form and inactive form).
so
X + sugar --- process ---> Xxx(salt) + H20
Sir, i need more information on the sugar n process

IS that all the drug will react with fructose or maltose ? I heard danf said that not all the drugs react.

and for the process is that we mix the sugar n drugs and add in some water then Vacumn it to separate the H2O then to get the salt or mix them and heat it up or other process ?

hope Sir can give me more information.
Thanks Again
Loon

 

Re: tablets

Posted by danf on July 3, 2000, at 12:03:59

In reply to Thanks Cam, posted by Leong Khah Loon on July 3, 2000, at 11:04:38

sugars & other things are used as mechanical binders. This is so the pill will hold together. The binders need several characteristics.

Not to change the pH of the drug,

to make measuring the amount of material in the pill easier

to make dissolving of the pill uniform & in the right part of the digestive tract

to not cause either the drug or the drug /binder combination to deterioate

binders are also used to keep humidity, air & light from causing the drug to deterioate & the pill from crumbling

The binder is usually what holds the pill together & provides the mechanical strength of the pill. coating are added to the pill to do some of the same things binders do.

sugars are often used as is common talc & several other things. This should all be in one of your text books

 

Loon

Posted by Cam W. on July 3, 2000, at 13:25:25

In reply to Thanks Cam, posted by Leong Khah Loon on July 3, 2000, at 11:04:38

> Thanks Cam
>
> i think thats what my prof want
> if for experiment purpose
> that mean a DRUGS (named X )add in sugar
> (eg. fructose or maltose) then go through a process then become a salt (or tablet form and inactive form).
> so
> X + sugar --- process ---> Xxx(salt) + H20
> Sir, i need more information on the sugar n process
>
> IS that all the drug will react with fructose or maltose ? I heard danf said that not all the drugs react.
>
> and for the process is that we mix the sugar n drugs and add in some water then Vacumn it to separate the H2O then to get the salt or mix them and heat it up or other process ?
>
> hope Sir can give me more information.
> Thanks Again
> Loon

Loon - What you are talking about is 2 separate processes.

1) Transforming a drug in solution to a solid powder.
- commonly hydrochloric acid (HCl) is added to a drug solution whose pH is above 7 (below pH of 7 - a basic solution is used - will have a -OH group in the molecule). The HCl in solution dissociates to hydrogen ion and a chloride ion. The chloride ion binds to the drug in solution and causes the drug to precipitate out. The hydrogen ion from the HCl and the hydroxyl group from the the drug solution turns into water. This water is vacuumed off or is left to evaporate.

2) Turning powdered drug into a tablet.
- This is where the sugar, binders and other excipients (fillers) are added to the drug and pressed into a tablet. Most of the ingredients will be dry, so there is no need to remove water.

Hope this is clearer - Cam
P.S. danf is right about the characteristics of the fillers.

 

PS: Loon

Posted by danf on July 3, 2000, at 15:55:25

In reply to Loon, posted by Cam W. on July 3, 2000, at 13:25:25

This site is for people that want to discuss treatment & meds for illness.

sorry, but making pills is not part of that.

perhaps you should look for a pharm site.

good luck in your endeavors.

wish I could spell.


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