Shown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Ingo on January 29, 2000, at 15:50:47
Hi,
I am on Parnate for about 6 weeks. It really helps with anxiety but it´s not stimulating, as many people report. In contrary, it keeps me tired most of the time and I have this feeling that I don´t care about anything.
I wonder if anyone has tried Parnate with the same results (or somewhat not what they expected / hoped for) and switched to Moclobemide and had better results.
Thanks for any replies!
Posted by jd on January 30, 2000, at 3:26:09
In reply to Parnate vs Moclobemide in terms of Social phobia, posted by Ingo on January 29, 2000, at 15:50:47
Ingo,
I've seen a number of accounts of people who get very tired while on Parnate: this may have something to do with its effect on sleep quality or perhaps just with the MAO inhibition. In any event, moclobemide may be worth trying if you have access to it: it's certainly an easier med to take, although it's probably not as effective as MAOIs for some people with social phobia. Have you considered/tried Nardil or Marplan, the other MAOIs? Likewise, have you done a trial of an SSRI like Paxil or Prozac? As you probably know, one minor problem is that switching to any of these from Parnate would probably require a wash-out period of at least two weeks to be safe.
--jd
> Hi,
> I am on Parnate for about 6 weeks. It really helps with anxiety but it´s not stimulating, as many people report. In contrary, it keeps me tired most of the time and I have this feeling that I don´t care about anything.
> I wonder if anyone has tried Parnate with the same results (or somewhat not what they expected / hoped for) and switched to Moclobemide and had better results.
> Thanks for any replies!
Posted by S. Suggs on January 30, 2000, at 4:57:56
In reply to Parnate vs Moclobemide in terms of Social phobia, posted by Ingo on January 29, 2000, at 15:50:47
What is your does of parnate? I've been on it for about 3 months with a significant increase in energy level, but when it wears off, I have to keep moving, or I'll nod off. I currently take 60 mg daily. Blessings,
S. Suggs
Posted by Ingo on January 30, 2000, at 8:37:58
In reply to Re: Parnate vs Moclobemide in terms of Social phobia, posted by S. Suggs on January 30, 2000, at 4:57:56
> What is your does of parnate? I've been on it for about 3 months with a significant increase in energy level, but when it wears off, I have to keep moving, or I'll nod off. I currently take 60 mg daily. Blessings,
>
> S. SuggsI´m on it for aboug 2 months and made my way up to 60mgs in two or three divided doses in the morning and a few hours later. It helps in terms of my social phobia, that I am more relaxed around people and the anticipatory anxiety doesn´t bother me that much. Talking about the energy level, it seems to be doing just the opposite for me: I often sleep for 1-2hrs a little while after I have dosed.
the only good thing about it is that I sometimes don´t *require* as much energy as before, for example in social settings which were quite stressfull before!
:c)
Posted by Ingo on January 30, 2000, at 8:38:09
In reply to Re: Parnate vs Moclobemide in terms of Social phobia, posted by jd on January 30, 2000, at 3:26:09
> Ingo,
> I've seen a number of accounts of people who get very tired while on Parnate: this may have something to do with its effect on sleep quality or perhaps just with the MAO inhibition. In any event, moclobemide may be worth trying if you have access to it: it's certainly an easier med to take, although it's probably not as effective as MAOIs for some people with social phobia. Have you considered/tried Nardil or Marplan, the other MAOIs? Likewise, have you done a trial of an SSRI like Paxil or Prozac? As you probably know, one minor problem is that switching to any of these from Parnate would probably require a wash-out period of at least two weeks to be safe.
> --jd
>
>
I live in Germany and have tried Prozac and Paxil earlier last year with very good results, but both times they lasted only a few weeks or maybe two months, so I thought before having the same with some other SSRI, I switch to a whole different class of AD, and Parnate sounded promissing (with its supposedly energizing and anti anxiety properties.
Nardil is not available over here and Marplan has been taken taken off the market some years ago, I think due to health problems. So my only options are to try the other (reverible) MAOI Moclobemide or look into other things like buspropion or something along the line.
Or maybe I augment the Parnate with something else.
Hmmm... if only I knew beforehand what the outcome would be, I wouldn´t be wasting months and months with the "wrong" meds.
Have a good day!
Posted by Noa on January 30, 2000, at 9:30:44
In reply to Re: Parnate vs Moclobemide in terms of Social phobia, posted by Ingo on January 30, 2000, at 8:38:09
> Hmmm... if only I knew beforehand what the outcome would be, I wouldn´t be wasting months and months with the "wrong" meds.
You said it! The quest for the right combo is time consuming and can make us weary and discouraged.
Posted by Scott L. Schofield on January 30, 2000, at 13:29:34
In reply to Parnate vs Moclobemide in terms of Social phobia, posted by Ingo on January 29, 2000, at 15:50:47
> Hi,
> I am on Parnate for about 6 weeks. It really helps with anxiety but it´s not stimulating, as many people report. In contrary, it keeps me tired most of the time and I have this feeling that I don´t care about anything.
> I wonder if anyone has tried Parnate with the same results (or somewhat not what they expected / hoped for) and switched to Moclobemide and had better results.
> Thanks for any replies!
I hope you get plenty of replies. I would really like to know how successful moclobemide (Manerix) can be for social phobia.About four years ago, the manufacturer (Roche, I believe) was conducting clinical trials in the U.S. for the indication of social phobia. Of course, they wanted to get it approved by the FDA for anything, thereby making it the first reversible MAO-inhibitor in the country. When I spoke to the drug company's director of U.S. investigations for moclobemide, he told me that they had dropped the project, but did not say why.
From some of the stuff that I've read, I think Nardil is the MAOI considered to be the best choice for treating social phobia. It is also often used in GAD (generalized anxiety disorder). I don't doubt that Parnate can be very effective too - I guess you have to try them to find out. It may seem counterintuitive that a drug known to be stimulating can reduce anxiety, but it definitely can.
As far as moclobemide is concerned, I have never thought much of it as an antidepressant - especially in severe cases. I have tried it, but my opinion is based more on what I have read than on what my personal experience had been. Likewise, the investigators whose opinions I respect a great deal don't think very much of moclobemide for social phobia either. The advantages of using moclobemide include a reduced need to follow a special diet of food-restrictions and a perhaps better side-effect profile.
Usual caveats apply. Moclobemide may work miracles for you.
- Scott
Posted by JIM on January 30, 2000, at 15:35:55
In reply to Re: Parnate vs Moclobemide in terms of Social phobia, posted by Scott L. Schofield on January 30, 2000, at 13:29:34
> > Hi,
>
> > I am on Parnate for about 6 weeks. It really helps with anxiety but it´s not stimulating, as many people report. In contrary, it keeps me tired most of the time and I have this feeling that I don´t care about anything.
>
> > I wonder if anyone has tried Parnate with the same results (or somewhat not what they expected / hoped for) and switched to Moclobemide and had better results.
>
> > Thanks for any replies!
>
>
> I hope you get plenty of replies. I would really like to know how successful moclobemide (Manerix) can be for social phobia.
>
> About four years ago, the manufacturer (Roche, I believe) was conducting clinical trials in the U.S. for the indication of social phobia. Of course, they wanted to get it approved by the FDA for anything, thereby making it the first reversible MAO-inhibitor in the country. When I spoke to the drug company's director of U.S. investigations for moclobemide, he told me that they had dropped the project, but did not say why.
>
> From some of the stuff that I've read, I think Nardil is the MAOI considered to be the best choice for treating social phobia. It is also often used in GAD (generalized anxiety disorder). I don't doubt that Parnate can be very effective too - I guess you have to try them to find out. It may seem counterintuitive that a drug known to be stimulating can reduce anxiety, but it definitely can.
>
> As far as moclobemide is concerned, I have never thought much of it as an antidepressant - especially in severe cases. I have tried it, but my opinion is based more on what I have read than on what my personal experience had been. Likewise, the investigators whose opinions I respect a great deal don't think very much of moclobemide for social phobia either. The advantages of using moclobemide include a reduced need to follow a special diet of food-restrictions and a perhaps better side-effect profile.
>
> Usual caveats apply. Moclobemide may work miracles for you.
>
>
> - Scott>
>
I have tried parnate, mannerix and nardil. The best results I have experienced has been with Nardil. Mannerix is a very week anti-depressant and even at high doses I found it did nothing for me. Parnate had too many side effects for me to cope with and made me very tired. Nardil has helped with both depression and social anxiety. It is a good medication with proven results.
Posted by Kim on February 1, 2000, at 23:45:54
In reply to Re: Parnate vs Moclobemide in terms of Social phobia, posted by JIM on January 30, 2000, at 15:35:55
> > > Hi,
> >
> > > I am on Parnate for about 6 weeks. It really helps with anxiety but it´s not stimulating, as many people report. In contrary, it keeps me tired most of the time and I have this feeling that I don´t care about anything.
> >
I also have found Parnate to be very sedating. After several different augmentation attempts, my doctor prescribed Dexedrine to counteract the sleepiness. It worked well & the correct dose didn't make me feel buzzy or anything. Then I moved to a new state, and new Pdoc was upset at the combination of Parnate & dexedrine (even though I gave him copies of information from this site and others showing the legitimacy of this combination), so he made me quit the dexedrine & I'm back to drowsy. One note if your doctor lets you try it--for some reason the long-acting spansules didn't work, I had to take the shorter-acting tablets. Apparently Ritalin also works for some, although it didn't for me.
Kim
Posted by Ingo on February 2, 2000, at 18:49:51
In reply to Re: Parnate vs Moclobemide in terms of Social phobia, posted by Kim on February 1, 2000, at 23:45:54
> > > > Hi,
> > >
> > > > I am on Parnate for about 6 weeks. It really helps with anxiety but it´s not stimulating, as many people report. In contrary, it keeps me tired most of the time and I have this feeling that I don´t care about anything.
> > >
> I also have found Parnate to be very sedating. After several different augmentation attempts, my doctor prescribed Dexedrine to counteract the sleepiness. It worked well & the correct dose didn't make me feel buzzy or anything. Then I moved to a new state, and new Pdoc was upset at the combination of Parnate & dexedrine (even though I gave him copies of information from this site and others showing the legitimacy of this combination), so he made me quit the dexedrine & I'm back to drowsy. One note if your doctor lets you try it--for some reason the long-acting spansules didn't work, I had to take the shorter-acting tablets. Apparently Ritalin also works for some, although it didn't for me.
> KimHi Kim,
Thanks for your post, I think Parnate + Amphetamines (or any other stimulant for that matter) is a pretty interesting combination but I guess it´s very hard to convince a doc to prescribe it on top of the Parnate. As I have heard, even ADHD people sometimes have a hard time getting them prescribed. I have some experience with (illegal) Amphetamines prior to the Parnate and I think that was more self-medicating rather than anything else. It is one of the few things that actually *completely* turns my Social Anxiety around. It makes me very confident and social, talkative and in general does everything anti-SP meds are supposed to do. I don´t get all jumpy and euphoric, like most recreational users do. I actually become quite calm and satisfied with myself. So it turned out to be a 100% cure for my social phobia (and the depression that in turn was probably just caused by the frustration and misery of being anxious all the time and not able to do what you want to do). Also it helped with my concentration and some other annoying thing, for example I tend to forget words when I talk to somebody and have sometimes a hard time expressing what´s on my mind. I don´t know if there are any studies that support Stimulants as a treatment in Social Phobia. Looks like it´s time for another MedLine search :o)
Posted by Robert on February 2, 2000, at 22:19:05
In reply to Parnate vs Moclobemide in terms of Social phobia, posted by Ingo on January 29, 2000, at 15:50:47
> Hi,
> I am on Parnate for about 6 weeks. It really helps with anxiety but it´s not stimulating, as many people report. In contrary, it keeps me tired most of the time and I have this feeling that I don´t care about anything.
> I wonder if anyone has tried Parnate with the same results (or somewhat not what they expected / hoped for) and switched to Moclobemide and had better results.
> Thanks for any replies!I suffer from both social phobia and depression. Moclobemide helped with my depression, but did absolutely nothing for the social phobia. I am currently taking reboxetine(Edronax) and it helps both my social phobia and depression.
This is the end of the thread.
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