![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 40 to 64 of 147. Go back in thread:
Posted by farshad on March 18, 2018, at 15:15:18
In reply to Re: How can I block Cortisol? » farshad, posted by ed_uk2010 on March 18, 2018, at 14:57:07
> >also why do u not believe I have a mutation in my CRF1 gene?
>
> I don't not believe you! :)
>
> What I'm saying is that a particular mutation doesn't prove that you have severe high cortisol as the cause of your problems - the type that would be treated with a cortisol blocking drug. You can only prove that by specifically testing for high cortisol.
>
> The body has ways of balancing things out (homeostasis). If your CRF was abnormal, something else could have changed to balance that. This is why you can only diagnose a problem due to elevated cortisol by doing special tests for it.
>
>
>if the body had a way of balancing things then I wouldnt have this anxiety. People wouldnt have schizoprenia due too much dopamine etc.. so no I dont believe the body can always go into homeostasis. I will test for high cortisol first but I figured since its a long time to my appointment might aswell chat about it maybe I can learn some stuff and then when I meet my doctor bring it up to her.
Posted by farshad on March 18, 2018, at 15:18:11
In reply to Re: How can I block Cortisol? » farshad, posted by ed_uk2010 on March 18, 2018, at 15:13:10
> Hi Farshad,
>
> >In Sweden anything that exceeds 200 euros you just have to pay it once and you get the medication free for the whole year.
>
> Ah I see. Do you pay the full price or part of it? I'm guessing part of it. Prescriptions are very cheap in the England, but people still complain about paying (mainly because they don't know how much people have to pay elsewhere)! We have plenty of other expensive things to balance it out though :/
>
> >like I said im just taking the 4 dopamine drugs for my severe depression and it worked best for me. Nothing for anxiety.
>
> That's really good that your depression has improved. Do these meds make your anxiety worse or just the same? What does your anxiety feel like and what have you tried for it?
>
> >So what should I ask for them to check when im doing this cortisol test? Cortisol,ACTH,CRF1/CRF2 thats it?
>
> Most likely, your doctor will follow the protocol recommended by the local pathology department. If high cortisol is suspected, you should always have a careful physical examination at the hospital or clinic. Routine blood tests would be taken (urea & electrolytes, full blood count, fasting glucose etc). Then, you would have one or two of the tests listed below as a starting point:
>
> 1. A 24 hour urine collection and analysis for cortisol content (this test is often done twice),
>
> 2. A late night saliva test for cortisol concentration,
>
> 3. An overnight dexamethasone suppression test with morning analysis of blood cortisol level.
>
> These are the first tests. If they were normal, that would probably be all. If they were abnormal, they would look into it in more detail.no these dopamine drugs dont make my anxiety worse I think it makes it better just a tiny bit tho.
I have tried SNRI,SSRI,MAOI,Buspar and some others I dont remember
Posted by ed_uk2010 on March 18, 2018, at 15:52:02
In reply to Re: How can I block Cortisol?, posted by farshad on March 18, 2018, at 15:15:18
>I dont believe the body can always go into homeostasis.
Now that is true, but you don't know until you test because anxiety has so many causes.
>I can learn some stuff and then when I meet my doctor bring it up to her.
It's definitely good to educate yourself. The most important realisation is the limitation of your own knowledge though. Even the best neuroscientists only have a limited understanding of anxiety. You have to keep an open mind.
Posted by ed_uk2010 on March 18, 2018, at 15:55:38
In reply to Re: How can I block Cortisol?, posted by farshad on March 18, 2018, at 15:18:11
>I have tried SNRI, SSRI, MAOI, Buspar and some others I dont remember,
What is your anxiety like? Describe it.
Also, which MAOI did you try?
How does your anxiety respond to benzodiazepines?
Are you diagnosed with depression and anxiety? Maybe something else like bipolar?
You will always tend to get bad suggestions if you don't say much about your problems :/
Posted by farshad on March 18, 2018, at 16:01:26
In reply to Re: How can I block Cortisol? » farshad, posted by ed_uk2010 on March 18, 2018, at 15:55:38
> >I have tried SNRI, SSRI, MAOI, Buspar and some others I dont remember,
>
> What is your anxiety like? Describe it.
>
> Also, which MAOI did you try?
>
> How does your anxiety respond to benzodiazepines?
>
> Are you diagnosed with depression and anxiety? Maybe something else like bipolar?
>
> You will always tend to get bad suggestions if you don't say much about your problems :/
>
>Nardil did nothing for me just side effects.
My anxiety is that just anxiety, I also have OCD . Both which are related to high cortisol.
Its like im in a constant anxious state and every second as I type this I feel anxiety even tho I have no reason to. I have gotten used to this feeling but my head is so hot. I believe its due to too much CRF1 activation and there are CRF1 receptors in the amygdala . Which lead to an overactive amygdala. Tried 2 benzos , klonopin which had no effect at all then I also tried Valium which worked meh. No I have no diagnosists .
Im 100% its cortisol related.
Posted by ed_uk2010 on March 18, 2018, at 16:07:13
In reply to Re: How can I block Cortisol?, posted by farshad on March 18, 2018, at 16:01:26
>Its like im in a constant anxious state and every second as I type this I feel anxiety even tho I have no reason to.
When you tried SSRIs for your anxiety, how long did you take them for?
>No I have no diagnosis.
What sort of doctor do you see? A psychiatrist? A general practitioner/family doctor?
Posted by farshad on March 18, 2018, at 16:11:05
In reply to Re: How can I block Cortisol? » farshad, posted by ed_uk2010 on March 18, 2018, at 16:07:13
> >Its like im in a constant anxious state and every second as I type this I feel anxiety even tho I have no reason to.
>
> When you tried SSRIs for your anxiety, how long did you take them for?
>
> >No I have no diagnosis.
>
> What sort of doctor do you see? A psychiatrist? A general practitioner/family doctor?
>tried ssri for months. seein a family doctor.
Posted by ed_uk2010 on March 18, 2018, at 16:17:35
In reply to Re: How can I block Cortisol?, posted by farshad on March 18, 2018, at 16:11:05
So why aren't you seeing a specialist/psychiatrist?
Posted by farshad on March 18, 2018, at 16:23:09
In reply to Re: How can I block Cortisol? » farshad, posted by ed_uk2010 on March 18, 2018, at 16:17:35
> So why aren't you seeing a specialist/psychiatrist?
they refuse to help me and say I should just go the therapy route since no meds work for me.
Posted by ed_uk2010 on March 18, 2018, at 16:33:27
In reply to Re: How can I block Cortisol?, posted by farshad on March 18, 2018, at 16:23:09
> > So why aren't you seeing a specialist/psychiatrist?
So, meds like pramipexole, did you buy online?
Posted by farshad on March 18, 2018, at 16:41:55
In reply to Re: How can I block Cortisol?, posted by ed_uk2010 on March 18, 2018, at 16:33:27
> > > So why aren't you seeing a specialist/psychiatrist?
>
> So, meds like pramipexole, did you buy online?
>yeah I get them all online besides wellbutrin which I get from my doctor .
Posted by ed_uk2010 on March 18, 2018, at 16:46:34
In reply to Re: How can I block Cortisol?, posted by farshad on March 18, 2018, at 16:41:55
So have you been referred to someone for the endocrine tests?
Posted by farshad on March 18, 2018, at 16:47:48
In reply to Re: How can I block Cortisol? » farshad, posted by ed_uk2010 on March 18, 2018, at 16:46:34
> So have you been referred to someone for the endocrine tests?
>family doctor which I get my wellbutrin from
Posted by SLS on March 19, 2018, at 8:43:45
In reply to Re: How can I block Cortisol?, posted by ed_uk2010 on March 18, 2018, at 16:33:27
For what it's worth, I tried mifepristone for 8 consecutive days. It did not help with depression at all. However, by the eighth day, I felt washed-out and unwell. The protocol at the time called for treatment of a short duration so as not to not cause adrenal exhaustion. Although I do not have psychotic depression, I thought that it was worth a try.
- Scott
Posted by farshad on March 19, 2018, at 14:13:05
In reply to Re: How can I block Cortisol?, posted by SLS on March 19, 2018, at 8:43:45
has anyone seen this study ? its from 1998 . I think they are suggesting there could be CRF1 mutations but unrelated to cushings disease>
I quote from the study ...No mutations affecting the CRF1-R protein have been found in all tumors analyzed. However, we found a significant overexpression of the CRF1-R messenger RNA in ACTH-secreting pituitary adenomas vs. inactive adenomas and normal pituitaries. We conclude that mutations of the CRF1-R are unlikely to be involved in Cushing's disease. We suggest that the overexpression of the CRF1-R messenger RNA may be related to a disturbed receptor regulation in ACTH-secreting pituitary adenomas...
https://www.ncbi.nlm.nih.gov/pubmed/9745449
English is my 3rd language so maybe someone can explain this that understands it better_
Posted by farshad on March 19, 2018, at 14:16:15
In reply to Re: How can I block Cortisol?, posted by farshad on March 19, 2018, at 14:13:05
> has anyone seen this study ? its from 1998 . I think they are suggesting there could be CRF1 mutations but unrelated to cushings disease>
>
> I quote from the study ...No mutations affecting the CRF1-R protein have been found in all tumors analyzed. However, we found a significant overexpression of the CRF1-R messenger RNA in ACTH-secreting pituitary adenomas vs. inactive adenomas and normal pituitaries. We conclude that mutations of the CRF1-R are unlikely to be involved in Cushing's disease. We suggest that the overexpression of the CRF1-R messenger RNA may be related to a disturbed receptor regulation in ACTH-secreting pituitary adenomas...
>
> https://www.ncbi.nlm.nih.gov/pubmed/9745449
>
> English is my 3rd language so maybe someone can explain this that understands it better_I found 2 possible mutations that I have related to ACTH>
PDE8B https://www.selfdecode.com/gene/pde8b/#advanced-summary
ACE (Angiotensin I converting enzyme) https://www.selfdecode.com/gene/ace/
Posted by farshad on March 19, 2018, at 14:20:38
In reply to Re: How can I block Cortisol?, posted by farshad on March 19, 2018, at 14:16:15
> > has anyone seen this study ? its from 1998 . I think they are suggesting there could be CRF1 mutations but unrelated to cushings disease>
> >
> > I quote from the study ...No mutations affecting the CRF1-R protein have been found in all tumors analyzed. However, we found a significant overexpression of the CRF1-R messenger RNA in ACTH-secreting pituitary adenomas vs. inactive adenomas and normal pituitaries. We conclude that mutations of the CRF1-R are unlikely to be involved in Cushing's disease. We suggest that the overexpression of the CRF1-R messenger RNA may be related to a disturbed receptor regulation in ACTH-secreting pituitary adenomas...
> >
> > https://www.ncbi.nlm.nih.gov/pubmed/9745449
> >
> > English is my 3rd language so maybe someone can explain this that understands it better_
>
> I found 2 possible mutations that I have related to ACTH>
>
> PDE8B https://www.selfdecode.com/gene/pde8b/#advanced-summary
>
> ACE (Angiotensin I converting enzyme) https://www.selfdecode.com/gene/ace/--------------
One mutation in human PDE8B (His350Pro), from a patient with severe adrenal hyperplasia, impaired PDE8B catalytic activity, and its expression in Hela cells resulted in increased cAMP-signaling, suggesting a role for cAMP in development of adrenal hyprerplasia. Such PDE8B mutations may not directly cause adrenal hyperplasia, however, since PDE8B KO mice do not develop adrenal tumors (Tsai and Beavo 2011). Inactivating PDE11A gene mutations are also associated with the development of adrenal hyperplasia and Cushing syndrome (Libe et al. 2008), and with Carney complex (CNC). CNC is caused by germline mutations in the alpha regulatory subunit of PKA (PRKARIA) and is associated with endocrine tumors, including nodular adrenal hyperplasia and adrenal and testicular tumors (Levy et al. 2011;Libe et al. 2011). PDE11A mutations may also play a role in susceptibility to prostate cancer (Faucz et al. 2011) and testicular germ cell tumors (TGCT) (Horvath et al. 2009).
------------https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275405/
https://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia
Posted by farshad on March 19, 2018, at 14:29:45
In reply to Re: How can I block Cortisol?, posted by farshad on March 19, 2018, at 14:20:38
> > > has anyone seen this study ? its from 1998 . I think they are suggesting there could be CRF1 mutations but unrelated to cushings disease>
> > >
> > > I quote from the study ...No mutations affecting the CRF1-R protein have been found in all tumors analyzed. However, we found a significant overexpression of the CRF1-R messenger RNA in ACTH-secreting pituitary adenomas vs. inactive adenomas and normal pituitaries. We conclude that mutations of the CRF1-R are unlikely to be involved in Cushing's disease. We suggest that the overexpression of the CRF1-R messenger RNA may be related to a disturbed receptor regulation in ACTH-secreting pituitary adenomas...
> > >
> > > https://www.ncbi.nlm.nih.gov/pubmed/9745449
> > >
> > > English is my 3rd language so maybe someone can explain this that understands it better_
> >
> > I found 2 possible mutations that I have related to ACTH>
> >
> > PDE8B https://www.selfdecode.com/gene/pde8b/#advanced-summary
> >
> > ACE (Angiotensin I converting enzyme) https://www.selfdecode.com/gene/ace/
>
> --------------
> One mutation in human PDE8B (His350Pro), from a patient with severe adrenal hyperplasia, impaired PDE8B catalytic activity, and its expression in Hela cells resulted in increased cAMP-signaling, suggesting a role for cAMP in development of adrenal hyprerplasia. Such PDE8B mutations may not directly cause adrenal hyperplasia, however, since PDE8B KO mice do not develop adrenal tumors (Tsai and Beavo 2011). Inactivating PDE11A gene mutations are also associated with the development of adrenal hyperplasia and Cushing syndrome (Libe et al. 2008), and with Carney complex (CNC). CNC is caused by germline mutations in the alpha regulatory subunit of PKA (PRKARIA) and is associated with endocrine tumors, including nodular adrenal hyperplasia and adrenal and testicular tumors (Levy et al. 2011;Libe et al. 2011). PDE11A mutations may also play a role in susceptibility to prostate cancer (Faucz et al. 2011) and testicular germ cell tumors (TGCT) (Horvath et al. 2009).
> ------------
>
> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275405/
>
>
> https://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia
>https://en.wikipedia.org/wiki/Angiotensin (Angiotensin I converting enzyme)
Posted by farshad on March 19, 2018, at 14:35:21
In reply to Re: How can I block Cortisol? » farshad, posted by farshad on March 19, 2018, at 14:29:45
> > > > has anyone seen this study ? its from 1998 . I think they are suggesting there could be CRF1 mutations but unrelated to cushings disease>
> > > >
> > > > I quote from the study ...No mutations affecting the CRF1-R protein have been found in all tumors analyzed. However, we found a significant overexpression of the CRF1-R messenger RNA in ACTH-secreting pituitary adenomas vs. inactive adenomas and normal pituitaries. We conclude that mutations of the CRF1-R are unlikely to be involved in Cushing's disease. We suggest that the overexpression of the CRF1-R messenger RNA may be related to a disturbed receptor regulation in ACTH-secreting pituitary adenomas...
> > > >
> > > > https://www.ncbi.nlm.nih.gov/pubmed/9745449
> > > >
> > > > English is my 3rd language so maybe someone can explain this that understands it better_
> > >
> > > I found 2 possible mutations that I have related to ACTH>
> > >
> > > PDE8B https://www.selfdecode.com/gene/pde8b/#advanced-summary
> > >
> > > ACE (Angiotensin I converting enzyme) https://www.selfdecode.com/gene/ace/
> >
> > --------------
> > One mutation in human PDE8B (His350Pro), from a patient with severe adrenal hyperplasia, impaired PDE8B catalytic activity, and its expression in Hela cells resulted in increased cAMP-signaling, suggesting a role for cAMP in development of adrenal hyprerplasia. Such PDE8B mutations may not directly cause adrenal hyperplasia, however, since PDE8B KO mice do not develop adrenal tumors (Tsai and Beavo 2011). Inactivating PDE11A gene mutations are also associated with the development of adrenal hyperplasia and Cushing syndrome (Libe et al. 2008), and with Carney complex (CNC). CNC is caused by germline mutations in the alpha regulatory subunit of PKA (PRKARIA) and is associated with endocrine tumors, including nodular adrenal hyperplasia and adrenal and testicular tumors (Levy et al. 2011;Libe et al. 2011). PDE11A mutations may also play a role in susceptibility to prostate cancer (Faucz et al. 2011) and testicular germ cell tumors (TGCT) (Horvath et al. 2009).
> > ------------
> >
> > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275405/
> >
> >
> > https://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia
> >
>
> https://en.wikipedia.org/wiki/Angiotensin (Angiotensin I converting enzyme)
I dont know what to think this is all so confusing. So I have mutations in my CRF1 gene specifically with the PDE8B causing excessive cortisol and the Secretion of CRH, ACTH, and cortisol is increased by stimulation of angiotensin AT(1) receptors.So it all goes in a loop and just further pushes each other to the max?
Posted by farshad on March 19, 2018, at 14:40:31
In reply to Re: How can I block Cortisol?, posted by farshad on March 19, 2018, at 14:35:21
> > > > > has anyone seen this study ? its from 1998 . I think they are suggesting there could be CRF1 mutations but unrelated to cushings disease>
> > > > >
> > > > > I quote from the study ...No mutations affecting the CRF1-R protein have been found in all tumors analyzed. However, we found a significant overexpression of the CRF1-R messenger RNA in ACTH-secreting pituitary adenomas vs. inactive adenomas and normal pituitaries. We conclude that mutations of the CRF1-R are unlikely to be involved in Cushing's disease. We suggest that the overexpression of the CRF1-R messenger RNA may be related to a disturbed receptor regulation in ACTH-secreting pituitary adenomas...
> > > > >
> > > > > https://www.ncbi.nlm.nih.gov/pubmed/9745449
> > > > >
> > > > > English is my 3rd language so maybe someone can explain this that understands it better_
> > > >
> > > > I found 2 possible mutations that I have related to ACTH>
> > > >
> > > > PDE8B https://www.selfdecode.com/gene/pde8b/#advanced-summary
> > > >
> > > > ACE (Angiotensin I converting enzyme) https://www.selfdecode.com/gene/ace/
> > >
> > > --------------
> > > One mutation in human PDE8B (His350Pro), from a patient with severe adrenal hyperplasia, impaired PDE8B catalytic activity, and its expression in Hela cells resulted in increased cAMP-signaling, suggesting a role for cAMP in development of adrenal hyprerplasia. Such PDE8B mutations may not directly cause adrenal hyperplasia, however, since PDE8B KO mice do not develop adrenal tumors (Tsai and Beavo 2011). Inactivating PDE11A gene mutations are also associated with the development of adrenal hyperplasia and Cushing syndrome (Libe et al. 2008), and with Carney complex (CNC). CNC is caused by germline mutations in the alpha regulatory subunit of PKA (PRKARIA) and is associated with endocrine tumors, including nodular adrenal hyperplasia and adrenal and testicular tumors (Levy et al. 2011;Libe et al. 2011). PDE11A mutations may also play a role in susceptibility to prostate cancer (Faucz et al. 2011) and testicular germ cell tumors (TGCT) (Horvath et al. 2009).
> > > ------------
> > >
> > > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275405/
> > >
> > >
> > > https://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia
> > >
> >
> > https://en.wikipedia.org/wiki/Angiotensin (Angiotensin I converting enzyme)
>
>
> I dont know what to think this is all so confusing. So I have mutations in my CRF1 gene specifically with the PDE8B causing excessive cortisol and the Secretion of CRH, ACTH, and cortisol is increased by stimulation of angiotensin AT(1) receptors.
>
> So it all goes in a loop and just further pushes each other to the max?
>
here are the 2 CRF1 mutations btw
https://www.selfdecode.com/gene/crhr1-it1/
https://www.selfdecode.com/gene/mgc57346-crhr1/
Posted by farshad on March 19, 2018, at 15:16:20
In reply to Re: How can I block Cortisol?, posted by farshad on March 19, 2018, at 14:40:31
> > > > > > has anyone seen this study ? its from 1998 . I think they are suggesting there could be CRF1 mutations but unrelated to cushings disease>
> > > > > >
> > > > > > I quote from the study ...No mutations affecting the CRF1-R protein have been found in all tumors analyzed. However, we found a significant overexpression of the CRF1-R messenger RNA in ACTH-secreting pituitary adenomas vs. inactive adenomas and normal pituitaries. We conclude that mutations of the CRF1-R are unlikely to be involved in Cushing's disease. We suggest that the overexpression of the CRF1-R messenger RNA may be related to a disturbed receptor regulation in ACTH-secreting pituitary adenomas...
> > > > > >
> > > > > > https://www.ncbi.nlm.nih.gov/pubmed/9745449
> > > > > >
> > > > > > English is my 3rd language so maybe someone can explain this that understands it better_
> > > > >
> > > > > I found 2 possible mutations that I have related to ACTH>
> > > > >
> > > > > PDE8B https://www.selfdecode.com/gene/pde8b/#advanced-summary
> > > > >
> > > > > ACE (Angiotensin I converting enzyme) https://www.selfdecode.com/gene/ace/
> > > >
> > > > --------------
> > > > One mutation in human PDE8B (His350Pro), from a patient with severe adrenal hyperplasia, impaired PDE8B catalytic activity, and its expression in Hela cells resulted in increased cAMP-signaling, suggesting a role for cAMP in development of adrenal hyprerplasia. Such PDE8B mutations may not directly cause adrenal hyperplasia, however, since PDE8B KO mice do not develop adrenal tumors (Tsai and Beavo 2011). Inactivating PDE11A gene mutations are also associated with the development of adrenal hyperplasia and Cushing syndrome (Libe et al. 2008), and with Carney complex (CNC). CNC is caused by germline mutations in the alpha regulatory subunit of PKA (PRKARIA) and is associated with endocrine tumors, including nodular adrenal hyperplasia and adrenal and testicular tumors (Levy et al. 2011;Libe et al. 2011). PDE11A mutations may also play a role in susceptibility to prostate cancer (Faucz et al. 2011) and testicular germ cell tumors (TGCT) (Horvath et al. 2009).
> > > > ------------
> > > >
> > > > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275405/
> > > >
> > > >
> > > > https://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia
> > > >
> > >
> > > https://en.wikipedia.org/wiki/Angiotensin (Angiotensin I converting enzyme)
> >
> >
> > I dont know what to think this is all so confusing. So I have mutations in my CRF1 gene specifically with the PDE8B causing excessive cortisol and the Secretion of CRH, ACTH, and cortisol is increased by stimulation of angiotensin AT(1) receptors.
> >
> > So it all goes in a loop and just further pushes each other to the max?
> >
> here are the 2 CRF1 mutations btw
> https://www.selfdecode.com/gene/crhr1-it1/
> https://www.selfdecode.com/gene/mgc57346-crhr1/
>
So its obvious that there is something wrong with my genetics specificaly the cortisol/fight or flight stress related ones, which is why I think I have such bad anxiety . Can anyone help me out so I can understand this simple?
Here are some other cortisol genes I found I have problems with(does this make sense to anyone?):
https://www.selfdecode.com/gene/gnas/#advanced-summary - Constitutive activation of the adenylate cyclase enzyme leads to over-production of several hormones IE cortisol?
https://www.selfdecode.com/gene/nr3c2/#advanced-summary - Mutations in the NR3C2 gene lead to a nonfunctional or abnormally functioning mineralocorticoid receptor protein that cannot properly regulate the specialized proteins that transport sodium and potassium
2 others
https://www.selfdecode.com/gene/h6pd/#advanced-summary%C2%A0%C2%A0
Posted by farshad on March 19, 2018, at 15:30:37
In reply to Re: How can I block Cortisol?, posted by farshad on March 19, 2018, at 15:16:20
> > > > > > > has anyone seen this study ? its from 1998 . I think they are suggesting there could be CRF1 mutations but unrelated to cushings disease>
> > > > > > >
> > > > > > > I quote from the study ...No mutations affecting the CRF1-R protein have been found in all tumors analyzed. However, we found a significant overexpression of the CRF1-R messenger RNA in ACTH-secreting pituitary adenomas vs. inactive adenomas and normal pituitaries. We conclude that mutations of the CRF1-R are unlikely to be involved in Cushing's disease. We suggest that the overexpression of the CRF1-R messenger RNA may be related to a disturbed receptor regulation in ACTH-secreting pituitary adenomas...
> > > > > > >
> > > > > > > https://www.ncbi.nlm.nih.gov/pubmed/9745449
> > > > > > >
> > > > > > > English is my 3rd language so maybe someone can explain this that understands it better_
> > > > > >
> > > > > > I found 2 possible mutations that I have related to ACTH>
> > > > > >
> > > > > > PDE8B https://www.selfdecode.com/gene/pde8b/#advanced-summary
> > > > > >
> > > > > > ACE (Angiotensin I converting enzyme) https://www.selfdecode.com/gene/ace/
> > > > >
> > > > > --------------
> > > > > One mutation in human PDE8B (His350Pro), from a patient with severe adrenal hyperplasia, impaired PDE8B catalytic activity, and its expression in Hela cells resulted in increased cAMP-signaling, suggesting a role for cAMP in development of adrenal hyprerplasia. Such PDE8B mutations may not directly cause adrenal hyperplasia, however, since PDE8B KO mice do not develop adrenal tumors (Tsai and Beavo 2011). Inactivating PDE11A gene mutations are also associated with the development of adrenal hyperplasia and Cushing syndrome (Libe et al. 2008), and with Carney complex (CNC). CNC is caused by germline mutations in the alpha regulatory subunit of PKA (PRKARIA) and is associated with endocrine tumors, including nodular adrenal hyperplasia and adrenal and testicular tumors (Levy et al. 2011;Libe et al. 2011). PDE11A mutations may also play a role in susceptibility to prostate cancer (Faucz et al. 2011) and testicular germ cell tumors (TGCT) (Horvath et al. 2009).
> > > > > ------------
> > > > >
> > > > > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275405/
> > > > >
> > > > >
> > > > > https://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia
> > > > >
> > > >
> > > > https://en.wikipedia.org/wiki/Angiotensin (Angiotensin I converting enzyme)
> > >
> > >
> > > I dont know what to think this is all so confusing. So I have mutations in my CRF1 gene specifically with the PDE8B causing excessive cortisol and the Secretion of CRH, ACTH, and cortisol is increased by stimulation of angiotensin AT(1) receptors.
> > >
> > > So it all goes in a loop and just further pushes each other to the max?
> > >
> > here are the 2 CRF1 mutations btw
> > https://www.selfdecode.com/gene/crhr1-it1/
> > https://www.selfdecode.com/gene/mgc57346-crhr1/
> >
>
>
> So its obvious that there is something wrong with my genetics specificaly the cortisol/fight or flight stress related ones, which is why I think I have such bad anxiety . Can anyone help me out so I can understand this simple?
>
> Here are some other cortisol genes I found I have problems with(does this make sense to anyone?):
>
>
>
> https://www.selfdecode.com/gene/gnas/#advanced-summary - Constitutive activation of the adenylate cyclase enzyme leads to over-production of several hormones IE cortisol?
>
>
>
> https://www.selfdecode.com/gene/nr3c2/#advanced-summary - Mutations in the NR3C2 gene lead to a nonfunctional or abnormally functioning mineralocorticoid receptor protein that cannot properly regulate the specialized proteins that transport sodium and potassium
>
>
>
>
>
> 2 others
>
>
>
> https://www.selfdecode.com/gene/h6pd/#advanced-summary%C2%A0%C2%A0
>
>
>
> https://www.selfdecode.com/gene/serpina6/#advanced-summaryDo you guys think all of this can be fixed just by taking Metyrapone? Since it blocks cortisol.
Posted by farshad on March 19, 2018, at 16:30:38
In reply to Re: How can I block Cortisol?, posted by farshad on March 19, 2018, at 15:30:37
> > > > > > > > has anyone seen this study ? its from 1998 . I think they are suggesting there could be CRF1 mutations but unrelated to cushings disease>
> > > > > > > >
> > > > > > > > I quote from the study ...No mutations affecting the CRF1-R protein have been found in all tumors analyzed. However, we found a significant overexpression of the CRF1-R messenger RNA in ACTH-secreting pituitary adenomas vs. inactive adenomas and normal pituitaries. We conclude that mutations of the CRF1-R are unlikely to be involved in Cushing's disease. We suggest that the overexpression of the CRF1-R messenger RNA may be related to a disturbed receptor regulation in ACTH-secreting pituitary adenomas...
> > > > > > > >
> > > > > > > > https://www.ncbi.nlm.nih.gov/pubmed/9745449
> > > > > > > >
> > > > > > > > English is my 3rd language so maybe someone can explain this that understands it better_
> > > > > > >
> > > > > > > I found 2 possible mutations that I have related to ACTH>
> > > > > > >
> > > > > > > PDE8B https://www.selfdecode.com/gene/pde8b/#advanced-summary
> > > > > > >
> > > > > > > ACE (Angiotensin I converting enzyme) https://www.selfdecode.com/gene/ace/
> > > > > >
> > > > > > --------------
> > > > > > One mutation in human PDE8B (His350Pro), from a patient with severe adrenal hyperplasia, impaired PDE8B catalytic activity, and its expression in Hela cells resulted in increased cAMP-signaling, suggesting a role for cAMP in development of adrenal hyprerplasia. Such PDE8B mutations may not directly cause adrenal hyperplasia, however, since PDE8B KO mice do not develop adrenal tumors (Tsai and Beavo 2011). Inactivating PDE11A gene mutations are also associated with the development of adrenal hyperplasia and Cushing syndrome (Libe et al. 2008), and with Carney complex (CNC). CNC is caused by germline mutations in the alpha regulatory subunit of PKA (PRKARIA) and is associated with endocrine tumors, including nodular adrenal hyperplasia and adrenal and testicular tumors (Levy et al. 2011;Libe et al. 2011). PDE11A mutations may also play a role in susceptibility to prostate cancer (Faucz et al. 2011) and testicular germ cell tumors (TGCT) (Horvath et al. 2009).
> > > > > > ------------
> > > > > >
> > > > > > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275405/
> > > > > >
> > > > > >
> > > > > > https://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia
> > > > > >
> > > > >
> > > > > https://en.wikipedia.org/wiki/Angiotensin (Angiotensin I converting enzyme)
> > > >
> > > >
> > > > I dont know what to think this is all so confusing. So I have mutations in my CRF1 gene specifically with the PDE8B causing excessive cortisol and the Secretion of CRH, ACTH, and cortisol is increased by stimulation of angiotensin AT(1) receptors.
> > > >
> > > > So it all goes in a loop and just further pushes each other to the max?
> > > >
> > > here are the 2 CRF1 mutations btw
> > > https://www.selfdecode.com/gene/crhr1-it1/
> > > https://www.selfdecode.com/gene/mgc57346-crhr1/
> > >
> >
> >
> > So its obvious that there is something wrong with my genetics specificaly the cortisol/fight or flight stress related ones, which is why I think I have such bad anxiety . Can anyone help me out so I can understand this simple?
> >
> > Here are some other cortisol genes I found I have problems with(does this make sense to anyone?):
> >
> >
> >
> > https://www.selfdecode.com/gene/gnas/#advanced-summary - Constitutive activation of the adenylate cyclase enzyme leads to over-production of several hormones IE cortisol?
> >
> >
> >
> > https://www.selfdecode.com/gene/nr3c2/#advanced-summary - Mutations in the NR3C2 gene lead to a nonfunctional or abnormally functioning mineralocorticoid receptor protein that cannot properly regulate the specialized proteins that transport sodium and potassium
> >
> >
> >
> >
> >
> > 2 others
> >
> >
> >
> > https://www.selfdecode.com/gene/h6pd/#advanced-summary%C2%A0%C2%A0
> >
> >
> >
> > https://www.selfdecode.com/gene/serpina6/#advanced-summary
>
> Do you guys think all of this can be fixed just by taking Metyrapone? Since it blocks cortisol.
How am I supposed to decipher all this?..
https://www.selfdeco...m/gene/cyp17a1/ - this condition affects the function of certain hormone-producing glands
https://www.selfdeco.../gene/ppargc1b/ - Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids.
https://www.selfdeco...m/gene/txnrd2/
https://www.selfdeco...dvanced-summary - adrenocorticotropic
Posted by Phillipa on March 19, 2018, at 18:08:43
In reply to Re: How can I block Cortisol?, posted by farshad on March 19, 2018, at 16:30:38
Hi what languages do you speak? I am no med expert. I looked at you first post link and googled this. Don't know if will help or not Phillipa
https://rarediseases.info.nih.gov/diseases/12867/acth-secreting-pituitary-adenoma
Posted by Lamdage22 on March 20, 2018, at 12:36:33
In reply to Re: How can I block Cortisol? » farshad, posted by Phillipa on March 19, 2018, at 18:08:43
how is cortisol measured? I may do the same test
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