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Dr. Bob is Robert Hsiung, MD,
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Posted by bearfan on July 8, 2011, at 0:40:46
In reply to Re: Day 7 of Viibryd, posted by joe schmoe on July 8, 2011, at 0:11:38
My experience with Lexapro/Celexa withdrawals haven't been that hard to deal with. I did have quite a bit of trouble with Paxil and Effexor however. There is some dizziness accompanied by Viibryd, which might be associated with some of the Serotonin agonist activity much in the same way in how Buspar has. Unfortunately, Viibryd hasn't been on of those drugs that 'kicks in' fast. I've been on it for a little more than a week and haven't been really impressed with ability to make me more proactive in social environments or make me more motivated. There is however, a noticeable anxiolytic effect, which I hope continues. As far a side effects, there are some spaciness, laziness, dizziness and tiredness that are noticeable, and slight digestive issues (although not as bad as some other SSRIs). I want to try to give it at least 3-4 weeks, before deciding to go back to something stronger.
Posted by joe schmoe on July 8, 2011, at 2:07:07
In reply to Re: Day 7 of Viibryd, posted by bearfan on July 8, 2011, at 0:40:46
Well yeah, the first week you are only at 10 mg, the second 20 mg, you don't even start the recommended final dose till the third week (40 mg) so if you are using a starter pack like me, I definitely wouldn't judge it for a month or more at least.
Posted by Phillipa on July 8, 2011, at 19:52:53
In reply to Re: Day 7 of Viibryd, posted by joe schmoe on July 8, 2011, at 2:07:07
Comes in a starter pack? Any reason why I wonder? Phillipa
Posted by joe schmoe on July 8, 2011, at 23:31:25
In reply to Re: Day 7 of Viibryd » joe schmoe, posted by Phillipa on July 8, 2011, at 19:52:53
> Comes in a starter pack? Any reason why I wonder? Phillipa
Probably because of the three different dosages you use when titrating up, or whatever it's called when you increase dosage over time.
Posted by joe schmoe on July 9, 2011, at 15:07:09
In reply to Re: Day 7 of Viibryd, posted by joe schmoe on July 8, 2011, at 23:31:25
Well, I don't want to get too graphic, but the sexual side of things is definitely improving in every way.
Had "morning wood" for the first time I can remember in years!
Posted by Phillipa on July 9, 2011, at 19:16:36
In reply to Day 9 of Viibryd, posted by joe schmoe on July 9, 2011, at 15:07:09
I guess that's good!!! Phillipa
Posted by sigismund on July 10, 2011, at 2:18:59
In reply to Re: Day 9 of Viibryd » joe schmoe, posted by Phillipa on July 9, 2011, at 19:16:36
>I guess that's good!!!
It most certainly is, and suggests to me as well that you had some deep sleep.
Posted by joe schmoe on July 10, 2011, at 12:39:25
In reply to Re: Day 9 of Viibryd, posted by sigismund on July 10, 2011, at 2:18:59
I am pretty convinced at this point that the dizziness/spaceyness I have been feeling lately when standing up is not purely Celexa withdrawal, it is due to the Viibryd. There is no doubt that I feel much more dizzy as the day and evening go on (I have been taking Viibryd with breakfast, which for me is around noon). So I am going to switch to taking it shortly before bed (always with food) and see how that goes.
Hopefully the dizziness is just a temporary effect of getting used to the drug. In any case taking it at night should help.
I should mention I have had a few instances of restless leg syndrome while waking up from a nap in my easy chair. I have had this before from time to time over the years, so it is nothing alarming, especially since it only lasted a few minutes (I think it happened twice in the past ten days). But it is a weird enough sensation (if you've never experienced it, I can't convey what it's like) that I want to note it before I forget. Hasn't happened in bed at night, fortunately.
Posted by mtdewcmu on July 10, 2011, at 15:49:32
In reply to Day 10 of Viibryd, posted by joe schmoe on July 10, 2011, at 12:39:25
> I am pretty convinced at this point that the dizziness/spaceyness I have been feeling lately when standing up is not purely Celexa withdrawal, it is due to the Viibryd. There is no doubt that I feel much more dizzy as the day and evening go on (I have been taking Viibryd with breakfast, which for me is around noon). So I am going to switch to taking it shortly before bed (always with food) and see how that goes.
Part of Viibryd's effect is the same as Buspar. Buspar made me dizzy.
Posted by Lamdage on July 10, 2011, at 18:49:17
In reply to Re: Day 10 of Viibryd » joe schmoe, posted by mtdewcmu on July 10, 2011, at 15:49:32
Id like to see more new meds coming.. new maoi. how sweet would it be to have a nice variety
Posted by bearfan on July 10, 2011, at 18:55:19
In reply to Re: Day 10 of Viibryd, posted by Lamdage on July 10, 2011, at 18:49:17
There already is a new maoi in the works; it called tririma
No diet restrictions and as strong as the traditional ones. Its a strong Rima.
Posted by mtdewcmu on July 10, 2011, at 19:49:38
In reply to Re: Day 10 of Viibryd and new moai, posted by bearfan on July 10, 2011, at 18:55:19
> There already is a new maoi in the works; it called tririma
> No diet restrictions and as strong as the traditional ones. Its a strong Rima.That sounds almost too good to be true. Which part of Tririma eliminates the tyramine effect? The fact that it's reversible? Or the fact that it's selective for MAO-A? Wikipedia says MAO-A breaks down serotonin and norepinephrine, but MAO-B breaks down dopamine. So wouldn't Tririma sacrifice some effects on dopamine?
Posted by Phillipa on July 10, 2011, at 19:51:03
In reply to Re: Day 10 of Viibryd and new moai, posted by bearfan on July 10, 2011, at 18:55:19
Bearfan an oral med or patch? I can see the patch not requiring diet restriction but a pill goes through the digestive system? When's it due out? Phillipa
Posted by bearfan on July 10, 2011, at 20:14:21
In reply to Re: Day 10 of Viibryd and new moai » bearfan, posted by Phillipa on July 10, 2011, at 19:51:03
As far as I know its oral. Its similar to moclobermide but much stronger and taken one a day instead. Its in stage 2 trials do it should be availible a year or two. Although it wouldn't be a first line treatment
Posted by bearfan on July 10, 2011, at 20:15:51
In reply to Re: Day 10 of Viibryd and new moai » bearfan, posted by Phillipa on July 10, 2011, at 19:51:03
As far as I know its oral. Its similar to moclobermide but much stronger and taken one a day instead. Its in stage 2 trials do it should be availible a year or two. Although it wouldn't be a first line treatment
Posted by jhj on July 11, 2011, at 6:24:10
In reply to Re: Day 10 of Viibryd and new moai, posted by bearfan on July 10, 2011, at 20:15:51
One or Two years? i think you are too optimisticjhj
Posted by joe schmoe on July 12, 2011, at 15:52:11
In reply to Day 10 of Viibryd, posted by joe schmoe on July 10, 2011, at 12:39:25
Taking the Viibryd at night has gotten rid of the dizziness. Furthermore, my sense of taste has improved again - beers and dark chocolate taste pretty good, not too bitter. The longer between taking the medicine and tasting the food, the better, as far as bitterness is concerned.
Three more nights (including tonight) of the 20mg and then, onto the 40mg...where I'll really find out what this medicine feels like.
Posted by joe schmoe on July 15, 2011, at 13:47:47
In reply to Day 12 of Viibryd, posted by joe schmoe on July 12, 2011, at 15:52:11
Have been having trouble sleeping. I never had this when starting an ssri, then again I normally took them in the morning. I think a lot of these effects are probably temporary. Today I take my first 40mg pill. I don't want to do it during the day as I have a lot of work to do and don't want to risk the dizziness and fatigue returning. I will probably take it earlier in the evening though than I have been. Once I get a day when I can afford to experiment I will try taking it in the morning again - maybe I am used to the medicine enough for the dizziness to be gone (or maybe it was a parting present from going off Celexa).
Posted by iforgotmypassword on July 18, 2011, at 15:37:27
In reply to Re: Day 10 of Viibryd and new moai » bearfan, posted by mtdewcmu on July 10, 2011, at 19:49:38
that the 5-ht1a agonism is actually there, despite the research otherwise
Posted by joe schmoe on July 18, 2011, at 16:08:20
In reply to the dizziness might be a good sign, posted by iforgotmypassword on July 18, 2011, at 15:37:27
Have had several side effects. Loose bowels for a day or two at 20 mg, but that seems to have subsided. Still have some difficulty getting to sleep, and have had some bouts of restless legs. Dizziness and fatigue have virtually disappeared, so I am taking the medicine earlier and earlier in the day again in the hopes it will make it easier for me to get to sleep. Once asleep, I sleep well.
My sense of taste seems good (beers aren't too bitter) despite taking the medicine earlier in the day.
Have been on 40mg for the past three days (and now today) and so far, so good.
I still have a strong appetite for sweets and carbs and have not lost any weight. On the other hand, sexual thoughts and sensations are much improved over Celexa.
Posted by bearfan on July 18, 2011, at 18:41:08
In reply to Viibryd Day 18, posted by joe schmoe on July 18, 2011, at 16:08:20
Joe, I'm about on Day 18 as well. I've had similar side effects including loose stools and the occasional gas. It's not as bad as some other medications and its still noticeable and hasn't completely subsided. Sleep for me, has been better. I have been taking it right before I go to bed because it kind of makes me tired and dizzy. What positive things have you noticed? I do notice somewhat of a relief on anxiety, although my libido hasn't come back in full force like I was hoping (partly because i'm tapering town). Another thing I kind of noticed that I feel like I have a bit more of an emotional response to things. I don't stay in that neutral state like the traditional SSRIs. I can think of things in my head better about life events and situations without it just being 'blocked out' if that makes sense. Did you notice any improvement in social and executive functioning? I remember Lexapro made it more difficult to concentrate. While Effexor, Cymbalta, and to a lesser extent, Prozac helped.
Posted by joe schmoe on July 19, 2011, at 22:19:13
In reply to Re: Viibryd Day 18, posted by bearfan on July 18, 2011, at 18:41:08
> I have been taking it right before I go to bed because it kind of makes me tired and dizzy.
I am starting to get some fatigue and dizziness again now that I have been on the 40mg dose for a few days. Hopefully it will wear off as it did at the lower doses.
>What positive things have you noticed?Great increase in sexual sensation. Very good mood a lot of the time.
>I do notice somewhat of a relief on anxiety, although my libido hasn't come back in full force like I was hoping (partly because i'm tapering town).
Tapering down? You are taking another drug at the same time?
>Another thing I kind of noticed that I feel like I have a bit more of an emotional response to things. I don't stay in that neutral state like the traditional SSRIs. I can think of things in my head better about life events and situations without it just being 'blocked out' if that makes sense. Did you notice any improvement in social and executive functioning?
I am leading a fairly isolated life at the moment so I can't really judge things like social functioning. I also take clonazepam for social anxiety, so this drug is solely for depression.
Posted by SLS on July 20, 2011, at 5:57:57
In reply to Viibryd Day 18, posted by joe schmoe on July 18, 2011, at 16:08:20
Thanks, guys, for sharing your experiences with Viibryd.
- Scott
Posted by mantus on July 20, 2011, at 11:34:12
In reply to Re: Viibryd Day 18, posted by SLS on July 20, 2011, at 5:57:57
Yes, thank you all very much. And I ask out of my own personal decision as of yesterday to drop Nardil and try viibryd in two weeks that you continue with your experience. Could you also go a little more into any positive changes that you have seen or if any at all from the time of beginning viibryd? I have become frustrated to the point I can't deal with it anymore about the side effect of a spiking hr while standing since I have been on Nardil. I realize I could try different additional meds, but my bp has also been made lower by Nardil so even if I took something like a beta blocker for my hr it wouldn't increase my bp, and at this point I've just got to come to the understanding that Nardil for some reason is always going to have this negative side effect, and without adding more meds and trials and time and still not knowing for sure I will find an answer, i just have to drop it for the physical side effects and hope that the 2 week washout period isn't too killer, and that maybe something else will help the anxiety/depression without changing me so dramatically physically. Just know that people are interesting in your posts, and it can be very beneficial for anyone thinking about trying viibryd. We really don't have much else to go on as far as actual reports from people trying this med.
Thanks Again,
Mantus
Posted by mtdewcmu on July 20, 2011, at 13:39:15
In reply to Re: Viibryd Day 18, posted by mantus on July 20, 2011, at 11:34:12
> Yes, thank you all very much. And I ask out of my own personal decision as of yesterday to drop Nardil and try viibryd in two weeks that you continue with your experience. Could you also go a little more into any positive changes that you have seen or if any at all from the time of beginning viibryd? I have become frustrated to the point I can't deal with it anymore about the side effect of a spiking hr while standing since I have been on Nardil. I realize I could try different additional meds, but my bp has also been made lower by Nardil so even if I took something like a beta blocker for my hr it wouldn't increase my bp, and at this point I've just got to come to the understanding that Nardil for some reason is always going to have this negative side effect, and without adding more meds and trials and time and still not knowing for sure I will find an answer, i just have to drop it for the physical side effects and hope that the 2 week washout period isn't too killer, and that maybe something else will help the anxiety/depression without changing me so dramatically physically. Just know that people are interesting in your posts, and it can be very beneficial for anyone thinking about trying viibryd. We really don't have much else to go on as far as actual reports from people trying this med.
The low BP and spiking heart rate when standing are two sides of the same problem. When you stand up, your body has to compensate for the natural drop in BP. Nardil is inhibiting your normal responses, so your heart beats rapidly to compensate. http://en.wikipedia.org/wiki/Orthostatic_intolerance
A beta blocker would be pushing you in the wrong direction, because it would be inhibiting your BP even more. You would want an adrenergic agonist rather than an antagonist. I don't know what drugs are safe to add to Nardil, but you could ask your doctor about options or look up research on the subject. The problem can be documented with a simple test in the doctor's office. The pdoc might not have a BP cuff, but he/she could take your pulse and feel it jump when you stand.
If you stop Nardil, you'll have to go through a lengthy wash-out period, followed by another one if you want to restart it.
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