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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 33. This is the beginning of the thread.
Posted by ny2bk on December 22, 2007, at 10:08:26
Doing some reading i came across a med that seems more and more interesting to me.Its a anti psych med called MOLINDONE,appearently from what i read its semi mild compared to the others,as well as depending on the condition,ones which relate to me,might actualy have a anti depressant effect as well.
In fact pasted below is showing it in a comparison study to parnate,where it actualy had better results.Adding this to parnate or simply finding a way off parnate altogther is something i continue to search for,so please any input pro or con on this med is appreciated as it seems to be light in terms of available info.In particular im curious if its a usa based med,can it still be prescribed?Here below are both the link and simple pasting of the article.
Thanks and HAPPY HOLIDAYS!
http://jcp.sagepub.com/cgi/content/abstract/21/8/351
Comparison of molindone and tranylcypromine in the treatment of refractory depression
JG Small, JJ Kellams, JL Dennis, and V Milstein
A single-blind parallel study of 20 treatment-resistant hospitalized depressed patients showed that 10-30 mg/day molindone was more effective and less toxic than 20-30 mg tranylcypromine. Molindone-treated patients responded during the first week with particular improvement in anxiety symptoms and agitation. Extrapyramidal symptoms developed in half of the patients on molindone, which were effectively managed with amantadine. Early termination from the study because of clinical worsening or side effects occurred in seven patients on tranylcypromine and in none on molindone. These results suggest that molindone in low dosage may be helpful in the management of refractory depression and may have the further advantage of producing a more rapid response to treatment with fewer disabling side effects.
Posted by Squiggles on December 22, 2007, at 13:56:07
In reply to Please if anyone can help answer....., posted by ny2bk on December 22, 2007, at 10:08:26
I have no personal experience. Looking at the
Nemeroff handbook, I read that it is in the Typical Antipsycbotic Class (typically used for psychosis, schizophrenia, Alzheimer's or mania first stage), its primary effect like others in this class is Sedation.Mechanism: blocks postsynaptic DA (D1 D2 D3 D4)
receptors and/or act as antagonists at alpha1-adregenergic, serotenergic, histaminergic,
and cholinergic receptors.In a comparative table MOBAN -trade name or Molindone is as some others 3x less sedating than Thorazine (Chropromazine), Mellaril (Thioridazine), and Serentil (Mesoridazine);
3x less Anticholinergic to the ones above, and 3x less orthostatic hypotensive inducing to the above. However, it shares 3x to 2x as high EPS effects, as all the typical antipsychotics, except the ones mentioned above.EPS effects can be treated by a variety of drugs
like beta-blockers and Benadryl.Dr. Kevin Thompson gives a list of serious
side effects from these drugs in his book
"Medicines for Mental Health".For QT prolongation, the worst typical antypsychotics are:
Chlorpromazine, Droperidol, Haloperidol, Mesoridazine, Pimozide, Thioridazine, and Zotepine.
The principal drawback of all are:
Tardive Dyskinesia
Neuroleptic Malignant Syndrome
QT prolongation -- a heart block or arrhythmia
Extra Pyramidal Syndromes
Dystonia
Parkinsonism
AkathisiaChlorpromazine is the first antipsychotic
from the 50s. They are powerful drugs, it
seems and what one might call "carpet-bombing".That's what i found in my books. Maybe 2nd
generation antipsychotics are used now for
schizophrenia and psychosis.Squiggles
Posted by Maxime on December 22, 2007, at 16:08:29
In reply to Re: Please if anyone can help answer....., posted by Squiggles on December 22, 2007, at 13:56:07
Sounds like a med I would like to try. Of course it's not available in Canada. Boo.
Maxime
Posted by Phillipa on December 22, 2007, at 18:17:39
In reply to Wish it was available in Canada, posted by Maxime on December 22, 2007, at 16:08:29
Wierd as seems like nothing is in Canada except online pharmacies very strange. Phillipa
Posted by Maxime on December 22, 2007, at 20:07:14
In reply to Re: Wish it was available in Canada » Maxime, posted by Phillipa on December 22, 2007, at 18:17:39
> Wierd as seems like nothing is in Canada except online pharmacies very strange. Phillipa
I wouldn't say nothing is available. I have been on 45 different psych meds, so something is available.
Maxime
Posted by Justherself54 on December 22, 2007, at 22:10:33
In reply to Re: Wish it was available in Canada » Phillipa, posted by Maxime on December 22, 2007, at 20:07:14
> > Wierd as seems like nothing is in Canada except online pharmacies very strange. Phillipa
>
> I wouldn't say nothing is available. I have been on 45 different psych meds, so something is available.
>
> MaximeI concur Maxime..my pdoc says our government is super cautious before they release a medication..and fast to pull a med too..hence no serzone here..
Posted by Phillipa on December 22, 2007, at 22:21:15
In reply to Re: Wish it was available in Canada, posted by Justherself54 on December 22, 2007, at 22:10:33
You know as I started to read that that is the med I thought of first. Glad I didn't go on it. Phillipa ps although it might have worked who knows
Posted by Maxime on December 23, 2007, at 14:10:06
In reply to Re: Wish it was available in Canada, posted by Justherself54 on December 22, 2007, at 22:10:33
I don't mind that Health Canada is cautious. As for Serzone, I wouldn't want to take a med that causes liver damage.
Maxime
Posted by Phillipa on December 23, 2007, at 18:06:47
In reply to Re: Wish it was available in Canada » Justherself54, posted by Maxime on December 23, 2007, at 14:10:06
Maxie can't they all? Even tylenol does. Phillipa
Posted by Maxime on December 23, 2007, at 20:56:33
In reply to Re: Wish it was available in Canada » Maxime, posted by Phillipa on December 23, 2007, at 18:06:47
> Maxie can't they all? Even tylenol does. Phillipa
Phillipa, there is a big difference between the effects of Serzone compared to Tylenol. Be reasonable.
Maxime
Posted by Phillipa on December 23, 2007, at 22:37:48
In reply to Re: Wish it was available in Canada » Phillipa, posted by Maxime on December 23, 2007, at 20:56:33
Maxie is it that bad as the pdoc here I saw for a short while started me on the generic. It's that bad? He said it wasn't glad I went with my gut. any stories you know to tell? Thanks Phillipa
Posted by ny2bk on December 24, 2007, at 0:24:39
In reply to Re: Wish it was available in Canada » Maxime, posted by Phillipa on December 23, 2007, at 22:37:48
> Maxie is it that bad as the pdoc here I saw for a short while started me on the generic. It's that bad? He said it wasn't glad I went with my gut. any stories you know to tell? Thanks Phillipa
Can my thread please be respected phillipa,you started to conversion of the meds in general in canada,and totaly took away the aim,which is important to me as i come close to seeing my doc away.
Again i ask why do you post in a thread,as you did here,when your post has absolutly nothing to do with the topic?
Now ill get blocked for this,which is sad because i posted this in earnest as i stated im approaching my appt with my doc,and cant find any info on it anywhere,so i asked if anyone here has used it or knows of it,this was an important crucial aim of topic for me.
Phillipa as usual inserted in the post with a response having nothing to do with the topic at hand,and now due to that the entire thread has changed its course.
I respect threads,i always stay on topic,and post in hopes i am offering some type of relavent info to the topic.I dont think its fair she continues to post as if for no other reason than to be in the thread.I know ill get all sort of reactions,but can anyone honestly say her input had any relavence to my query?Please be civil and show the same respect i do and post to a thread with some,any information that actualy is relavent.If you think im being unfair,just ask yourself if you were in short need of finding out info on this med as you closed in on asking for it and this is what came of your thread,a discussion on serzone and meds with liver issues.Thank you phillipa.
Posted by Deputy 10derHeart on December 24, 2007, at 1:22:50
In reply to Re: Wish it was available in Canada, posted by ny2bk on December 24, 2007, at 0:24:39
> Again i ask why do you post in a thread,as you did here,when your post has absolutly nothing to do with the topic?
> Phillipa as usual inserted in the post with a response having nothing to do with the topic
>I don't think it's fair she continues to post as if for no other reason than to be in the thread.Please be don't post anything that might lead others to feel accused or put down, or jump to conclusions about the motivations of others.
>> Now ill get blocked for this
Not by me, you won't, as that isn't the action I deem appropriate at this time, in this specific situation. However, Dr. Bob has oversight over deputy decisions, and he may choose a different action.
A couple of thoughts...if in the future, you find you've written something like, "I'll get blocked for this," maybe wait a bit before submitting the post, or run it by a 'civility buddy?' I know I speak for all the deputies in saying we don't want posters to be PBC'd or blocked, so we hope you can find a way to follow the civility rules, even when feeling provoked. I know it can be difficult.
If your thread veers off topic - no matter what you feel is the reason - try posting again yourself with a *very* specific subject line (helps draw people who may give support/education) and a 2nd request to discuss your original question. I've seen this work effectively.
If you or others have questions about this or about posting policies in general, or are interested in alternative ways of expressing yourself, please see the FAQ: http://www.dr-bob.org/babble/faq.html#civil
Follow-ups regarding these issues should be directed to Admin and should of course be civil.
-- 10derHeart, acting as deputy for Dr. Bob
Posted by florence on December 24, 2007, at 3:48:16
In reply to Re: Wish it was available in Canada, posted by ny2bk on December 24, 2007, at 0:24:39
Totally insensitive of you....sorry that we are kinda frickin sick here and your attitude is the last thing we need..
geez....whose fault was it that u needed info so fast? maybe a library would be a better source of info for you.
Merry Christmas Phillippa! You have saved many people from the brink of despair....
Wish more people had your gift of compassion and sensitivity.
Nemeroff?? sounds like the name of a guy from Emory Univ. who was disciplined for , gosh I seemed to have forgotten......sorry....guess i can't contribute much to this thread afterall.
I do sew, however. Does that count?
florence
Posted by shasling on December 24, 2007, at 7:17:55
In reply to Your treatment of Phillippa was appalling!..., posted by florence on December 24, 2007, at 3:48:16
> 'Totally insensitive of you'
Where is the pcb for this??
>'....sorry that we are kinda frickin sick here and your attitude is the last thing we need..'Where is the pcb for this?
>
> 'geez....whose fault was it that u needed info so fast? maybe a library would be a better source of info for you.'The POINT of his post was that he has looked elsewhere and couldn't find anything, making a specific request here for information. The fact that phillipa feels compelled to offer a response to each thread is fine, but really, can she be careful to do it in such a way as to not hijack a specific request for information?
>> 'Merry Christmas Phillippa! You have saved many people from the brink of despair....'
Florence, with all due respect, you do not know the level of the original poster's despair. It IS quite possible that INFORMATION was what was going to save him. Thank God Squiggles got in with some real information before this became a discussion of Canada, serzone, etc, sewing (?) whatever.
> 'Wish more people had your gift of compassion and sensitivity.'Where is the pcb for this? And before you say that read back at his posts, Florence, you will find that he does in fact have a very high level of compassion and sensitivity, and ALWAYS offers useful information and support for others.
>
> 'Nemeroff?? sounds like the name of a guy from Emory Univ. who was disciplined for , gosh I seemed to have forgotten......sorry....guess i can't contribute much to this thread afterall.'
I don't get this at all. Just an effort to shotgun and try to damage every useful post in the thread I suppose.>
> 'I do sew, however. Does that count?'No. It doesn't.
> florenceMerry Christmas yourself. And I do hope you have a decent Christmas, ny2bk. Please hang in there; I hope the med proves helpful, and that you managed to get something useful from Squiggles before the thread went straight to hell. You shouldn't have to re-post it, anywhere else, once would have been enough.
suzie
MY pcb now, please. Florence will not get her well earned ones because they were in defense of Phillipa, but I'll take mine gladly.
Posted by Deputy Dinah on December 24, 2007, at 8:00:25
In reply to Your treatment of Phillippa was appalling!..., posted by florence on December 24, 2007, at 3:48:16
> Totally insensitive of you....sorry that we are kinda frickin sick here and your attitude is the last thing we need..
Please don't post anything that could lead others to feel accused or put down.
I appreciate your being supportive of another poster, but Dr. Bob asks that we do so within the civility guidelines of this site. An alternative would be to post positive things to or about the poster you are trying to support.
If you or others have questions about this or about posting policies in general, or are interested in alternative ways of expressing yourself, please see the FAQ:
http://www.dr-bob.org/babble/faq.html#civil
Follow-ups regarding these issues should be redirected to Psycho-Babble Administration. They, as well as replies to the above posts, should of course themselves be civil.
Dr. Bob is always free to override deputy decisions. His email is on the bottom of each page. Please feel free to email him if you believe this decision was made in error.
Dinah, acting as deputy to Dr. Bob
Posted by Deputy Dinah on December 24, 2007, at 8:04:44
In reply to Re: Your treatment of Phillippa was appalling!..., posted by shasling on December 24, 2007, at 7:17:55
> I don't get this at all. Just an effort to shotgun and try to damage every useful post in the thread I suppose.
Please don't post anything that could lead others to feel accused or put down.
I appreciate your being supportive of another poster, but Dr. Bob asks that we do so within the civility guidelines of this site. An alternative would be to post positive things to or about the poster you are trying to support.
If you or others have questions about this or about posting policies in general, or are interested in alternative ways of expressing yourself, please see the FAQ:
http://www.dr-bob.org/babble/faq.html#civil
Follow-ups regarding these issues should be redirected to Psycho-Babble Administration. They, as well as replies to the above posts, should of course themselves be civil.
Dr. Bob is always free to override deputy decisions. His email is on the bottom of each page. Please feel free to email him if you believe this decision was made in error.
Dinah, acting as deputy to Dr. Bob
Posted by Justherself54 on December 24, 2007, at 13:09:05
In reply to Re: Please if anyone can help answer....., posted by Squiggles on December 22, 2007, at 13:56:07
I'm sorry ny2bk for being part of the hijacking of your post..I sorry I don't have any answer for your questions..I hope you can find them and get feeling better..once again I'm sorry..
Posted by ny2bk on December 24, 2007, at 13:38:16
In reply to Re: Please if anyone can help answer....., posted by Justherself54 on December 24, 2007, at 13:09:05
> I'm sorry ny2bk for being part of the hijacking of your post..I sorry I don't have any answer for your questions..I hope you can find them and get feeling better..once again I'm sorry..
No need to apologize,i understand how easy a thread can go off topic,however this is not the first time certain people have done this,normaly i would never respond in such a strong way but when it happens in so many of your posts you cant help but to become frustrated.
Im sorry some people who innocently became part of the change in direction of the thread will take my comment as being directed to them,i ask if anyone feels so to please read the thread carefully and you can see the topic was comptly discarded.
Also in answer to one response where it was recomended to post a second one with a more urgent topic heading,all i can say to that was how much more urgent can i get then starting the heading with the word PLEASE.
I personaly thought my heading indeed showed a sense of urgency and importance.
I am over it however,i know the majority of people here post with good hearts,and good intentions,i wish you all a good holiday.
Posted by gardenergirl on December 25, 2007, at 1:32:04
In reply to Re: Please if anyone can help answer....., posted by ny2bk on December 24, 2007, at 13:38:16
> Also in answer to one response where it was recomended to post a second one with a more urgent topic heading,all i can say to that was how much more urgent can i get then starting the heading with the word PLEASE.This is cut and pasted from the post with the recommendation you refer to:
"If your thread veers off topic - no matter what you feel is the reason - try posting again yourself with a *very* specific subject line (helps draw people who may give support/education) and a 2nd request to discuss your original question. I've seen this work effectively."The word, "urgent" is nowhere in those statements. My guess is that deputy 10derheart was suggesting a second post with a "very specific" subject line so that the topic of the thread might be more clear to those skimming the threads. Your original subject line is rather vague and is less likely to attract the attention of anyone with the specific information you are looking for. At a minimum, I would recommend including the name of the med or meds in a subject line requesting information about specific meds. I'm guessing that's what Deputy 10derheart was also suggesting.
Happy holidays.
gg
Posted by Phillipa on December 25, 2007, at 13:42:50
In reply to Re: Please if anyone can help answer..... » ny2bk, posted by gardenergirl on December 25, 2007, at 1:32:04
Sorry just saw this seemed like the topic just switched. I appologize if asking about Canadian meds contributed to this. You know I like to get on some threads just cause they do vere off topic to something totally different and end up learning something too. But my apologise to original poster. But you know I would have never know that serzone was that dangerous to the liver had I not responded and it was Rx'd for me.I did now that Canada removed the med but never knew it was that dangerous. Thanks for heads up. I also see the problem with subject or thread line no med is mentioned. how about another try? Would that help?. Meanwhile I'll wipe my snotty nose, take my antibiotics, and nap. Merry Christmas GG. Phillipa
Posted by Sigismund on December 25, 2007, at 17:12:17
In reply to Please if anyone can help answer....., posted by ny2bk on December 22, 2007, at 10:08:26
It's interesting, but I am surprised that the comparison is between two drugs having (presumably) such different actions.
(Not that there's anything wrong with that.)Molindone is a little obscure.
I couldn't find it in Stahl, and I don't think it has been available here.
Posted by Phillipa on December 25, 2007, at 17:36:24
In reply to Re: Please if anyone can help answer..... » ny2bk, posted by Sigismund on December 25, 2007, at 17:12:17
Googled could only find it as in relation to the name of Moban an antipsychotic an old one? Phillipa
Posted by Kath on December 25, 2007, at 19:35:38
In reply to Re: Please if anyone can help answer....., posted by ny2bk on December 24, 2007, at 13:38:16
> I am over it however,i know the majority of people here post with good hearts,and good intentions,i wish you all a good holiday.
I'm glad things seem to be smoothed out now :-)I just want to say that, although I hardly post on this board, I feel the need to say that I agree with your statement above & want to say that I personally, include Phillipa as one of those who has a very good heart & very good intentions!
I hope everyone had a great holiday & hope you get the kind of support you need regarding your meds. :-)
Kath
Posted by kezia on December 26, 2007, at 14:56:38
In reply to Re: Please if anyone can help answer..... » gardenergirl, posted by Phillipa on December 25, 2007, at 13:42:50
> But you know I would have never know that serzone was that dangerous to the liver had I not responded and it was Rx'd for me.I did now that Canada removed the med but never knew it was that dangerous. Phillipa
Um, Phillipa, that's odd because you started a thread in April of this year when you were RX'd Serzone and the dangers/risks of Serzone were discussed in that thread. I can provide the link if you would like to refresh your memory.
Go forward in thread:
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