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Dr. Bob is Robert Hsiung, MD,
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Posted by ed_uk on February 1, 2005, at 12:51:46
In reply to Re: TO ED_UK URGENT!!! *NEW* SEROQUEL, posted by Jeroen on February 1, 2005, at 12:36:38
Hello,
>he wants me to immediatelly take 200 to 400 mg after a few days and not 25 mg
Well, here are the official UK dosage guidelines for using Seroquel in schizophrenia. The guidelines in Belgium are probably the same.
Take 25 mg twice daily on day 1, 50 mg twice daily on day 2, 100 mg twice daily on day 3, 150 mg twice daily on day 4, then adjusted according to response, usual range 300–450 mg daily in 2 divided doses; max. 750 mg daily.
Personally, I think you should increase the dose more slowly though, starting out at 12.5 or 25mg at bedtime. You could gradually work your way up to about 300mg/day over a few weeks.
>my doctor will not prescribe it
I think he probably would prescribe the 25mg tablets if you asked him to!!
Ed.
Posted by Jeroen on February 1, 2005, at 12:57:39
In reply to Re: TO ED_UK URGENT!!! *NEW* SEROQUEL » Jeroen, posted by ed_uk on February 1, 2005, at 12:51:46
can i just take 25 mg for a week then add more, i really think this medicine gave me psychosis taughts
the last thing i can miss is a drug induced psychosis!!!
ill sure ill kill myself!
Posted by Jeroen on February 1, 2005, at 13:03:13
In reply to Re: TO ED_UK URGENT!!! *NEW* SEROQUEL » Jeroen, posted by ed_uk on February 1, 2005, at 12:51:46
can i increase my dosage slowly upto 100 mg for a few weeks?
Posted by olysi79 on February 1, 2005, at 13:48:33
In reply to Re: I hate Thorazine!! » Ritch, posted by ed_uk on January 14, 2005, at 13:22:47
Hey Ed,
I've never tried Thorazine but it sounds like you and I have had similar experiences on APs. I get severe akathisia and panic attacks if I take them for too long, like I could blow right out of my skin, LOL even a low dose of friggin Seroquel did that to me. I get this internal intense urge to move, and I feel like I could walk around the world 100 times and it still wouldn't be enough, much like an agitated depression/mixed state. It's hard because those meds are excellent for intrustive thinking and whatnot. I wish they would come up with one that didn't rub you out with akathisia and other EPS stuff. Now I just take one as needed off and on as sort of a "reset" if things are getting out of hand, but it would be nice to have one that was reliable for long term use.> Hi,
>
> My experience with Thorazine....
>
> About 2 years ago I had a severe episode of OCD. While I was waiting for citalopram to work my pdoc gave me a prescription for Thorazine because I was desperate for relief.
>
> Effects........
>
> 25mg dose... drowsiness, mental slowing, mild dry mouth, no relief of OCD whatsoever.
>
> 50 mg dose.... some increased anxiety.
>
> I got desperate and took 150mg (max. daily dose is 1000mg) because my OCD was making me suicidal.....
>
> Result.........
>
> Severe anxiety,
> VERY severe akathisia- I was writhing and shouting,
> Dystonia of tongue.
> Mental confusion,
> strong anticholinergic side effects.
>
> Went to ER........
>
> Took 60 mg (12 tabs) of Valium to calm me down. At first they wouldn't give me more than 5mg so I has to make a scene and threaten to kill myslelf. I was the worst distress of my life- would not wish it on my worst enemy.
>
> Ed.
>
>
>
>
> Sever
Posted by ed_uk on February 2, 2005, at 7:07:25
In reply to QUESTION, posted by Jeroen on February 1, 2005, at 13:03:13
Hi Jeroen,
If you truly believe that Seroquel gave you psychotic thoughts, it would be very unwise to take it without your doctors supervision. If you do still want to try Seroquel, you would need to be closely monitored by your doctor while you increase the dose very gradually.
PLEASE, do not take any more medication without discussing it first with your new psychiatrist.
Would it be so bad to go into hospital for a short while to start clozapine??????
Ed.
Posted by ed_uk on February 2, 2005, at 7:12:28
In reply to Re: I hate Thorazine!! » ed_uk, posted by olysi79 on February 1, 2005, at 13:48:33
Hi!!
If you get akathisia from Seroquel don't try chlorpromazine!!!! When my akathisia was severe, moving about DID NOT help- but it was still hard to stop!! I got akathisia within 90 minutes of the high dose.
Which APs have you tried? How did you respond to each one? Which meds have you tried for akathisia? Inderal? Anticholinergics?
Ed.
Posted by Jeroen on February 2, 2005, at 8:39:17
In reply to Re: QUESTION » Jeroen, posted by ed_uk on February 2, 2005, at 7:07:25
i will try taking seroquel at low doses for my eye problem, and increase the dosage very safe
Posted by ed_uk on February 2, 2005, at 9:16:41
In reply to SEROQUEL, posted by Jeroen on February 2, 2005, at 8:39:17
Take care! Remember, in long term use, Seroquel needs to be taken twice daily ie. approximately every 12 hours, one dose in the morning and one dose before you go to bed. It's ok to take the whole dose at night (eg. 25mg) for the first few days of treatment.
Ed.
Posted by Jeroen on February 2, 2005, at 10:32:04
In reply to Re: SEROQUEL » Jeroen, posted by ed_uk on February 2, 2005, at 9:16:41
why not once a day? huh??? those meds are terrible?
Posted by ed_uk on February 2, 2005, at 11:31:59
In reply to Re: SEROQUEL, posted by Jeroen on February 2, 2005, at 10:32:04
Hi Jeroen,
It has a short half-life, it needs to be taken twice daily. It's only taken as a single dose at night when it's used to treat insomnia.
How to take Seroquel.....
Take the first dose in the morning and the second dose in the evening (about 12 hours apart).Watch out for strange thoughts!!!! I am worried about you Jeroen.
>those meds are terrible?
It's not so hard to take it twice daily is it?
PLEASE don't ignore my question........
Would you consider going into hospital to start clozapine?Ed.
PS. I like the name Jeroen. Is it your real name?
Posted by Jeroen on February 2, 2005, at 12:00:19
In reply to Re: SEROQUEL » Jeroen, posted by ed_uk on February 2, 2005, at 11:31:59
i dont know about the clozapine, i hate the hospital i am in now, all those doctors talk to me like i am a crazy dangerous people, i dont trust psyhciatric
if this eye problem doesnt cure, i dont care about my life anymore!
Posted by ed_uk on February 2, 2005, at 12:05:38
In reply to Re: SEROQUEL, posted by Jeroen on February 2, 2005, at 12:00:19
Hello,
>all those doctors talk to me like i am a crazy dangerous people
I know you're not dangerous! You'd only have to stay in the hospital for a short time. Imagine how you would feel if your blinking was gone, you probably wouldn't even care that you were in hospital.
>if this eye problem doesnt cure, i dont care about my life anymore!
You'll find a solution! Don't forget Botox.
Ed.
Posted by Jeroen on February 2, 2005, at 13:03:50
In reply to Re: SEROQUEL » Jeroen, posted by ed_uk on February 2, 2005, at 12:05:38
its not just blinking alone, my eyes make uncontrolled movements, especially they go up and then go left
Posted by Jeroen on February 2, 2005, at 13:04:07
In reply to Re: SEROQUEL, posted by Jeroen on February 2, 2005, at 13:03:50
yes jeroen is my real name
Posted by yxibow on February 2, 2005, at 17:20:53
In reply to Re: SEROQUEL » Jeroen, posted by ed_uk on February 2, 2005, at 9:16:41
> Take care! Remember, in long term use, Seroquel needs to be taken twice daily ie. approximately every 12 hours, one dose in the morning and one dose before you go to bed. It's ok to take the whole dose at night (eg. 25mg) for the first few days of treatment.
>
> Ed.Its been shown that Seroquel can be taken once a day (at night), but that depends on one's situation. (I happen to, but this of course varies).
Posted by Jeroen on February 2, 2005, at 17:31:42
In reply to Re: SEROQUEL, posted by yxibow on February 2, 2005, at 17:20:53
hi, i feel very depressed for 5 months now, i noticed that i am weaker atm, i do not want to engage in social contacts, i dont go out anymore
if i still have this in a year i will kill myself
i tryed 5 medicines with no result
Risperdal, FELT LIKE A ZOMBIE AND NOT GOOD AT ALL!!!!
Abilify, eye blinking felt drugged, insomnia, NOT GOOD!!!
GEODON 20 MG, TARDIVE DYSKINESIA eye blinking
HEADACHES, HARDCORE ANXIETY, AKATHASIASEROQUEL: POSSIBLE CREATES PSYCHOSIS WITH ME FELT HEAVY SEDATED AND CANNOT FUNCTION IN LIFE, I WAS ZOMBIE!!
ZYPREXA 5MG DAMN WHERE IS THE FOOD???? CAN NO LONGER TAKE IT BECAUSE OF TARDIVE DYSKINESIA CAUSED BY GEODON, this could be the only drug that might helped me
as you can see im very negative, and i should be!my life is destroyed because of the geodon
f*ck psychiatry and their drugs!
its not the first time people land in a wheel chair because of taking Zyprexa and other stuff
Posted by olysi79 on February 2, 2005, at 20:00:26
In reply to Re: I hate Thorazine!! » olysi79, posted by ed_uk on February 2, 2005, at 7:12:28
Hi Ed :)
I've only tried Seroquel and Zyprexa. Both tend to give me akathisia. I really like Zyprexa as emergency medicine, it really works, however if I ever were to take it for a long period of time, I'm sure the akathisia would be excrutiating. Seroquel(even at a low dose) gave me akathisia too. I've taken plain old Benedryl and Ativan to quell the symptoms. I'm wondering if Wellbutrin would help, as strange as it sounds. Wellbutrin tends to make more dopamine available, you never know. They say amphetamines help too, even though they're stimulating.> Hi!!
>
> If you get akathisia from Seroquel don't try chlorpromazine!!!! When my akathisia was severe, moving about DID NOT help- but it was still hard to stop!! I got akathisia within 90 minutes of the high dose.
>
> Which APs have you tried? How did you respond to each one? Which meds have you tried for akathisia? Inderal? Anticholinergics?
>
> Ed.
>
>
Posted by olysi79 on February 3, 2005, at 0:21:23
In reply to TO ED_UK, posted by Jeroen on February 2, 2005, at 17:31:42
Hi there,
Please keep on going, there is no magic bullet, it takes a combination of various medications and therapy. No one drug is perfect or works 100 percent. Often, you have to augment them with various others to get the desired effects, and even then, they won't solve everything. You will be okay, but you have to get used to medications and accept some of their side effects. For example, each SSRI has given me different side effect, some of which are uncomfortable. I've made the decision to put up with this because the little alternative is far worse, that being depression and anxiety.
I have had my depression and anxiety flare up off and on for a year now, but hey I'm ok! I take things as they come, am patient, and overall like I said, I'm ok. My med saren't perfect, but they help.> hi, i feel very depressed for 5 months now, i noticed that i am weaker atm, i do not want to engage in social contacts, i dont go out anymore
>
> if i still have this in a year i will kill myself
>
> i tryed 5 medicines with no result
>
> Risperdal, FELT LIKE A ZOMBIE AND NOT GOOD AT ALL!!!!
>
> Abilify, eye blinking felt drugged, insomnia, NOT GOOD!!!
>
> GEODON 20 MG, TARDIVE DYSKINESIA eye blinking
> HEADACHES, HARDCORE ANXIETY, AKATHASIA
>
> SEROQUEL: POSSIBLE CREATES PSYCHOSIS WITH ME FELT HEAVY SEDATED AND CANNOT FUNCTION IN LIFE, I WAS ZOMBIE!!
>
> ZYPREXA 5MG DAMN WHERE IS THE FOOD???? CAN NO LONGER TAKE IT BECAUSE OF TARDIVE DYSKINESIA CAUSED BY GEODON, this could be the only drug that might helped me
>
> as you can see im very negative, and i should be!
>
> my life is destroyed because of the geodon
>
> f*ck psychiatry and their drugs!
> its not the first time people land in a wheel chair because of taking Zyprexa and other stuff
>
>
Posted by ed_uk on February 3, 2005, at 7:44:56
In reply to Re: SEROQUEL, posted by yxibow on February 2, 2005, at 17:20:53
Hi Y!
Thanks for the link :-)
I'd generally still suggest taking it twice daily when used for psychosis- it's short half-life suggests that taking it once daily might lead to large fluctuations in the plasma concentration over 24h. Taking the whole dose at night might be optimal for some people though, esp. if it was effective in minimizing day-time drowsiness and/or improving compliance, YMMV!
Here is an interesting study- it's a small study though so I think it would be best to treat its conclusion with caution......
Can J Psychiatry. 2003 Apr;48(3):187-94.
A random-assignment, double-blind, clinical trial of once- vs twice-daily administration of quetiapine fumarate in patients with schizophrenia or schizoaffective disorder: a pilot study.
Chengappa KN, Parepally H, Brar JS, Mullen J, Shilling A, Goldstein JM.
Mayview State Hospital, 1601 Mayview Road, Bridgeville, PA 15017-1599, USA.
OBJECTIVE: To evaluate the efficacy and safety of administering quetiapine once vs twice daily. METHOD: Utilizing a double-blind design, 21 hospitalized adult men or women with DSM-IV schizophrenia or schizoaffective disorder, who had received unchanged doses (for 2 weeks) of either 400 or 600 mg daily of quetiapine administered in 2 doses, were randomly assigned to once- or twice-daily administration for 4 weeks and then crossed over to the opposite dosing regimen for an additional 4 weeks. Standard psychopathology and safety measures were used in the study. RESULTS: Nearly 70% (15/21) of the subjects met the a priori efficacy responder criteria with no statistical differences in response between those assigned to once- or twice-daily quetiapine administration. Statistical analyses confirmed that most subjects maintained efficacy during the switch to once- or twice-daily administration with quetiapine. A minority (15%) did experience worsening of symptoms or orthostatic hypotension during the crossover. Quetiapine was generally well tolerated at either twice- or once-daily administration. CONCLUSIONS: These pilot data suggest that it is clinically feasible to switch most quetiapine-treated subjects receiving a therapeutic twice-daily dosing schedule to a once-daily regimen. A minority may experience worsening of symptoms or orthostatic hypotension during the switch. This strategy of administering quetiapine entirely at bedtime may promote improved adherence to treatment.
Ed.
Posted by ed_uk on February 3, 2005, at 7:48:16
In reply to Re: I hate Thorazine!! » ed_uk, posted by olysi79 on February 2, 2005, at 20:00:26
Hi Chris :-) (I haven't got your name wrong, have I?!)
How effective did you find Benadryl compared to Ativan? What dose of Ativan did you use?
Have you ever tried Wellbutrin?
Ed.
Posted by ed_uk on February 3, 2005, at 7:59:16
In reply to TO ED_UK, posted by Jeroen on February 2, 2005, at 17:31:42
Hi Jeroen :-) Bonjour Jeroen :-) Goedemiddag Jeroen :-)
> i feel very depressed for 5 months now
Are you still taking amantadine? Is it still helping your depression?
>i tryed 5 medicines with no result
All the medicines that you've tried are antipsychotics, perhaps a different type of drug would be better. I think you should ask your new doctor for suggestions. Perhaps an antidepressant such as Sipralexa would be more helpful.
>SEROQUEL: POSSIBLE CREATES PSYCHOSIS WITH ME FELT HEAVY SEDATED AND CANNOT FUNCTION IN LIFE, I WAS ZOMBIE!!
Most people would feel awful if they suddenly took 400mg Seroquel! If you increase the dose gradually it should be much more pleasant. Please will you ask your new doctor to prescribe the 25mg tablets, I honestly believe that he would be fine about it if only you asked.
Ed.
Posted by olysi79 on February 3, 2005, at 9:29:12
In reply to Re: I hate Thorazine!! » olysi79, posted by ed_uk on February 3, 2005, at 7:48:16
Hi Ed- indeed you got my name right :) I found 100 mgs of over the counter Benedryl to be very helpful. Ativan was good, even at a low dose (roughly .25???). I have taken Wellbutrin before, a good medicine but watch out for anxiety and insomnia from it, but taken with an SSRI, it may be a great combo.
> Hi Chris :-) (I haven't got your name wrong, have I?!)
>
> How effective did you find Benadryl compared to Ativan? What dose of Ativan did you use?
>
> Have you ever tried Wellbutrin?
>
> Ed.
Posted by ed_uk on February 3, 2005, at 9:48:56
In reply to Re: I hate Thorazine!! » ed_uk, posted by olysi79 on February 3, 2005, at 9:29:12
Hi Chris!
> I have taken Wellbutrin before, a good medicine but watch out for anxiety and insomnia from it, but taken with an SSRI, it may be a great combo.
Yes, I would quite like to try bupropion. In the UK it's only used for smoking cessation though. Also, the government has warned doctors not to combine it with SSRIs. I mentioned it to my pdoc but he hadn't heard of it. Btw, what country do you live in?
Ed.
Posted by olysi79 on February 3, 2005, at 10:19:13
In reply to Re: Wellbutrin » olysi79, posted by ed_uk on February 3, 2005, at 9:48:56
oops I tried to post something back to you but goofed. I live in the U.S. and docs here prescribe it with SSRI's regularly. It's too bad they don't do that in the UK. I'd like to get on 100-150MGS/day to help with some of the dopamine problems I've been experiencing. Also I'm a light/moderate smoker and if it can help me quit, and all abotu it! I'm going to ask around the board for input on it. It may also help with these periodic bouts of depression and anxiety I go through. They're wierd, they last 2 to 3 days then head out the door. I call in unipolar cycling because I'm not having any hypomanias right now, just that. are trhere and APs you've taken that don't cause akathisia for you? I wish there was one out there that had a solidlong lasting anti-anxiety effect.
Chris> Hi Chris!
>
> > I have taken Wellbutrin before, a good medicine but watch out for anxiety and insomnia from it, but taken with an SSRI, it may be a great combo.
>
> Yes, I would quite like to try bupropion. In the UK it's only used for smoking cessation though. Also, the government has warned doctors not to combine it with SSRIs. I mentioned it to my pdoc but he hadn't heard of it. Btw, what country do you live in?
>
> Ed.
Posted by ed_uk on February 4, 2005, at 6:20:02
In reply to Re: Wellbutrin » ed_uk, posted by olysi79 on February 3, 2005, at 10:19:13
Hi Chris!
> I'd like to get on 100-150MGS/day to help with some of the dopamine problems I've been experiencing.
You might need 300mg to help you quit smoking though!
>It may also help with these periodic bouts of depression and anxiety I go through.
Some people find Wellbutrin causes/worsens anxiety. Did it have any effect on your anxiety?
>are there any APs you've taken that don't cause akathisia for you?
I've only tried chlorpromazine. Low doses didn't cause akathisia at all but at high doses it was very severe.
Not many people get akathisia from thioridazine (Mellaril) but it's rarely used anymore due to the risk of cardiac arrhythmias. It was the most popular AP in the UK for many years!
>I wish there was one out there that had a solidlong lasting anti-anxiety effect.
Chlorpromazine didn't reduce my anxiety at all :-(
Best Regards,
Ed.
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