![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 57 to 81 of 116. Go back in thread:
Posted by JLM on February 12, 2004, at 19:16:13
In reply to Cymbalta/Duloxetine--Something's Up, posted by Jack Smith on March 11, 2003, at 12:55:39
> There has got to be something going on with duloxetine that we just don't know about. I mean they got an approvable letter almost six months ago and knowing Lily's eagerness to get the stuff out, you think it would be here by now. I CANNOT believe that their manufacturing problems are that great. I mean Straterra is here which is also manufactured by Lily. Something is going on. Moreover, apparently Lily is asking for more volunteers to do more clinical trials for depression with cymbalta. I think this drug won't be out for a while, unfortunately. I hope I am wrong.
>
> So many times people get their hopes up. If you look through the archives, you will see posts saying that reboxetine would be out by the end of 1999! Now, we know it's never coming out. Also, you will see posts in 2000 saying that the selegiline patch will be out by the end of that year. Last I heard, someone here talked to Dr. Bodkin who said that he would bet it would be out by this time next year. I would take that bet in a heartbeat. . . . . I have high hopes for cymbalta but looks like I am going to just go with effexor--which seems to be a little less potent than duloxetine and because of its shorter half life almost postively has worse withdrawls.
>
> Just my two cents. Thanks for listening.
>
> JACK
Yes, 'something' is up indeed:"February 12, 2004
Student, 19, in Trial of New Antidepressant Commits Suicide
By GARDINER HARRIS
19-year-old college student who had shown no outward signs of depression killed herself over the weekend at an Eli Lilly & Company laboratory in Indianapolis where she had been participating in a company drug trial for an experimental antidepressant.The student, Traci Johnson, was one of 25 healthy patients at an Eli Lilly clinic who were being given larger than therapeutic doses of duloxetine, which will be known as Cymbalta if it is introduced as an antidepressant. Four days before her death, Ms. Johnson was taken off Cymbalta and given a placebo.
While Eli Lilly asserted that it had properly screened Ms. Johnson before the study started to ensure that she was healthy and had no mental problems, her death is being used by critics of a popular class of antidepressants to bolster their case that the widely used drugs carry the risk of suicidal tendencies for a small number of people, particularly young people.
Four other patients who were given the drug during earlier trials also committed suicide, the company said. The drug is being tested not only as an antidepressant but also as a possible treatment for stress urinary incontinence.
Ms. Johnson's death came less than a week after a federal advisory panel concluded that the Food and Drug Administration should issue stronger warnings to doctors that this class of antidepressants may be linked to suicide and violent behavior in children and teenagers.
A review board has told Eli Lilly to stop entering new patients into the trial, and to have all the current participants evaluated by an independent psychiatrist.
Robert Smith, a Lilly spokesman, said the company did not believe that duloxetine, the drug's generic name, caused the suicide.
"This drug has been studied in 9,000 patients, in depressed and nondepressed healthy people, and we have not been able to discern any signal between duloxetine and suicide or suicidal ideation," Mr. Smith said.
Ms. Johnson had not shown signs of depression, distress or mood swings throughout about a month in the trial, said Dr. Alan Breier, Lilly's chief medical officer.
Patients who abruptly stop therapy with some antidepressants often experience withdrawal symptoms that can include severe agitation, unusual dreams and night sweats. This is especially true of antidepressants like Paxil, made by GlaxoSmithKline, that leave the bloodstream quickly. Cymbalta also leaves the blood stream quickly.
Dr. Breier said Ms. Johnson did not appear to be suffering any withdrawal symptoms. He said the company might never be able to answer why Ms. Johnson killed herself.
"Most people who commit suicide in the general population leave people asking these kinds of questions," Dr. Breier said. "And just because this happens while someone is taking a drug doesn't mean the drug caused it."
Ms. Johnson did not leave a suicide note. She hanged herself in a shower stall Saturday night in the bathroom of Lilly's dormlike laboratory on the top two floors of the Indiana University Medical Center.
She had been attending nearby Indiana Bible College but left school to participate in the study because it paid $150 a day plus meals.
Whether antidepressants cause some people to commit suicide was an issue that flared briefly in the early 1990's but had been largely dismissed by mainstream researchers until last summer. That is when GlaxoSmithKline warned that a series of studies had found that children and teenagers given Paxil were more likely to attempt or think about suicide than those given a placebo.
Wyeth soon followed with a warning suggesting that its antidepressant, Effexor, should not be given to children. British and American drug regulators set to work studying the problem. The British soon concluded that most antidepressants in this class should not be used in children and teenagers since they have not proved effective in that population and could be linked to suicide.
The F.D.A. continues to study the issue, said Susan Cruzan, an agency spokeswoman. The agency is aware of Ms. Johnson's death and will evaluate its implications once the agency receives all of the needed information about it, Ms. Cruzan said."
She was a HEALTHY volunteer in a HEALTHY volunteer study. Hence, they can't use their standard 'it was the illness' arugment this time.
Folks, Lilly shelved this drug a long time ago as a possible AD. It only got brought back to life when r-fluoxetine blew up in their face, and they needed a successor to Prozac to maintain their market share.
Posted by Marilyn on February 17, 2004, at 8:37:21
In reply to Re: Cymbalta/Duloxetine timing, posted by fendleywood on July 19, 2003, at 11:59:42
More information:
http://www.antidepressantsfacts.com/2004-02-07-Traci-Johnson-19-duloxetine.htm
http://www.antidepressantsfacts.com/2004-02-13-FDA-concerned-mother.htm
http://www.antidepressantsfacts.com/Traci-Johnson-duloxetine-FDA.htm
Posted by bookgurl99 on April 18, 2004, at 12:11:55
In reply to Re: Cymbalta/Duloxetine timing, posted by Marilyn on February 17, 2004, at 8:37:21
If I have to take something not to have migraines every day, I wanna try this. I hope it comes out soon.
I feel bad about the suicide in the trials, but the doses those people were on were enormous -- not something most people would take. Also, I think it's pretty easy to fake _not_ being depressed if you need the money you'd make from a drug trial.
I took Serzone and it was the most 'normal,' I've ever felt, with no migraines. (Until I tried to go off of it.) This sounds like a cleaner version of it.
Posted by Marilyn on June 8, 2004, at 21:21:26
In reply to i wanna try it, posted by bookgurl99 on April 18, 2004, at 12:11:55
>> I took Serzone and it was the most 'normal,' I've ever felt, with no migraines. (Until I tried to go off of it.) This sounds like a cleaner version of it.
Yeah right, what about this "cleaner" version:
Anti-Depressant Serzone (Nefazodone, Dutonin)Taken Off Market in the United States. The drug was already taken off the market in Europe, Australia, New Zealand and Canada. In the case of Canada, Bristol-Myers acknowledged the reason was "adverse events including liver failure." One of those victims, Cassie Geisenhof, who was just 15 when a doctor prescribed Serzone for her depression, suffered irreversible liver damage three months later. Doctors rushed her in for an emergency liver transplant and blamed the Serzone. Unfortunately, Cassie Geisenhof suffered constant problems after her liver transplant. She lapsed into a coma and passed away on April 13 in a Minneapolis hospital.
http://www.antidepressantsfacts.com/2004-05-19-serzone-off-the-market-US.htm
Posted by Griobhtha on August 4, 2004, at 14:49:52
In reply to Cymbalta/Duloxetine--Something's Up, posted by Jack Smith on March 11, 2003, at 12:55:39
> There has got to be something going on with duloxetine that we just don't know about. I mean they got an approvable letter almost six months ago and knowing Lily's eagerness to get the stuff out, you think it would be here by now. I CANNOT believe that their manufacturing problems are that great. I mean Straterra is here which is also manufactured by Lily. Something is going on. Moreover, apparently Lily is asking for more volunteers to do more clinical trials for depression with cymbalta. I think this drug won't be out for a while, unfortunately. I hope I am wrong.
>
> So many times people get their hopes up. If you look through the archives, you will see posts saying that reboxetine would be out by the end of 1999! Now, we know it's never coming out. Also, you will see posts in 2000 saying that the selegiline patch will be out by the end of that year. Last I heard, someone here talked to Dr. Bodkin who said that he would bet it would be out by this time next year. I would take that bet in a heartbeat. . . . . I have high hopes for cymbalta but looks like I am going to just go with effexor--which seems to be a little less potent than duloxetine and because of its shorter half life almost postively has worse withdrawls.
>
> Just my two cents. Thanks for listening.
>
> JACK
CYMBALTA - With Drug Approval, Lilly Sighs Relief Griobhtha 8/4/04 -- http://www.dr-bob.org/babble/20040730/msgs/374053.htmlAP: Cymbalta, Lilly's Depression Drug Is Approved -- http://www.dr-bob.org/babble/20040730/msgs/374056.html
Posted by KimberlyDi on August 4, 2004, at 15:33:22
In reply to Re: Cymbalta/Duloxetine--Something's Up, posted by Griobhtha on August 4, 2004, at 14:49:52
Posted by KaraS on August 4, 2004, at 15:51:49
In reply to Re: Cymbalta/Duloxetine--Something's Up, posted by Griobhtha on August 4, 2004, at 14:49:52
I think a young woman committed suicide (supposedly with no history of depression) while on a trial of Cymbalta/duloxetine. That may be holding things up. (Don't ask me why she was taking it to begin with.)
Posted by caraher on August 4, 2004, at 16:26:43
In reply to Re: Cymbalta/Duloxetine--Something's Up, posted by KaraS on August 4, 2004, at 15:51:49
> I think a young woman committed suicide (supposedly with no history of depression) while on a trial of Cymbalta/duloxetine. That may be holding things up. (Don't ask me why she was taking it to begin with.)
True. She was a healthy paid volunteer with no history of depression. At the time of the suicide she was taking a placebo but had been taking duloxetine earlier in the study, according to the consent form for the study I'm in now.
In another forum I heard the FDA officially announced approval of Cymbalta today.
Posted by KaraS on August 4, 2004, at 16:41:01
In reply to Re: Cymbalta/Duloxetine--Something's Up, posted by caraher on August 4, 2004, at 16:26:43
> > I think a young woman committed suicide (supposedly with no history of depression) while on a trial of Cymbalta/duloxetine. That may be holding things up. (Don't ask me why she was taking it to begin with.)
>
> True. She was a healthy paid volunteer with no history of depression. At the time of the suicide she was taking a placebo but had been taking duloxetine earlier in the study, according to the consent form for the study I'm in now.
>
> In another forum I heard the FDA officially announced approval of Cymbalta today.
Yes, thank you. I just read that on the main board. Lots of people are very happy. Are you taking it currently? If so, what are you experiencing so far?
Posted by Marilyn on August 4, 2004, at 17:32:46
In reply to Re: Cymbalta/Duloxetine--Something's Up, posted by KaraS on August 4, 2004, at 16:41:01
> Yes, thank you. I just read that on the main
> board. Lots of people are very happy.Actually Cymbalta (duloxetine) is just another SSRI anti-depressant that also acts on nor-epinephrine (nor-adrenalin). It is comparable to Effexor (venlafaxine). Thus this new "miracle drug" offers potentially just as many horrendous side-effects that people already experienced on the other SSRIs.... and these people are definitely not so happy!
Read their experiences first:
http://www.antidepressantsfacts.com/experiences.htmAnother interesting site is:
http://www.drugawareness.orgMarilyn
Posted by caraher on August 4, 2004, at 17:35:06
In reply to Re: Cymbalta/Duloxetine--Something's Up, posted by KaraS on August 4, 2004, at 16:41:01
> Yes, thank you. I just read that on the main board. Lots of people are very happy. Are you taking it currently? If so, what are you experiencing so far?
I might be. In the study I'm in it's either Cymbalta, Lexapro or placebo (odds are 40-40-20). I'm only one week into the study and I've experienced some mild nausea. I've managed to be more productive at work the past few days, better able to concentrate, so it's early yet but I feel generally positive about how it's going.
Posted by caraher on August 4, 2004, at 17:42:59
In reply to Re: Cymbalta/Duloxetine--Something's Up...YES!, posted by Marilyn on August 4, 2004, at 17:32:46
> Actually Cymbalta (duloxetine) is just another SSRI anti-depressant that also acts on nor-epinephrine (nor-adrenalin). It is comparable to Effexor (venlafaxine). Thus this new "miracle drug" offers potentially just as many horrendous side-effects that people already experienced on the other SSRIs.... and these people are definitely not so happy!That's basically my understanding, that it's kinda like Effexor in terms of the neurotransmitters it acts on, but with different kinetics and possibly other differences I'm not competent to speak to, being neither a chemist nor a neurobiologist.
Certainly Cymbalta is solidly in the "marketing hype" phase of its use as an antidepressant. Certainly there are people who will react badly to it, just like pretty much every other drug. I think the truth for most patients, as always, will lie somewhere in between Lilly's claims and the tales of horror so readily cataloged on the web.
Posted by maximum-doser on August 4, 2004, at 18:30:11
In reply to Re: Cymbalta/Duloxetine--Something's Up, posted by Griobhtha on August 4, 2004, at 14:49:52
Does anyone know what Cymbalta will cost, and what the dosage is?
Posted by KaraS on August 4, 2004, at 18:39:51
In reply to Re: Cymbalta/Duloxetine--Something's Up...YES!, posted by caraher on August 4, 2004, at 17:42:59
>
> > Actually Cymbalta (duloxetine) is just another SSRI anti-depressant that also acts on nor-epinephrine (nor-adrenalin). It is comparable to Effexor (venlafaxine). Thus this new "miracle drug" offers potentially just as many horrendous side-effects that people already experienced on the other SSRIs.... and these people are definitely not so happy!
>
> That's basically my understanding, that it's kinda like Effexor in terms of the neurotransmitters it acts on, but with different kinetics and possibly other differences I'm not competent to speak to, being neither a chemist nor a neurobiologist.
>
> Certainly Cymbalta is solidly in the "marketing hype" phase of its use as an antidepressant. Certainly there are people who will react badly to it, just like pretty much every other drug. I think the truth for most patients, as always, will lie somewhere in between Lilly's claims and the tales of horror so readily cataloged on the web.
It's supposed to be different from Effexor in that it is more balanced in terms of the reuptake inhibition of norepinephrine (NE) and serotonin. Effexor only mildly inhibits NE reuptake and then only at higher dosages. This extra NE inhibition could make it quite different, and more powerful, than any of the SSRIs or Effexor. Unfortunately, it's short half-life does predispose it to withdrawal effects when going off of it but "no pain, no gain" I guess. I prefer to take more natural treatments but I'm in favor of anything that can help. Too many people are suffering way too much IMHO and I don't want to shut the door to any potential help.I agree with you completely that the truth of it's impact will lie somewhere between the hype and the horror stories.
Good luck with the rest of your trial. Please let us know how it turns out in the end (when will that be by the way?)
Kara
Posted by caraher on August 4, 2004, at 20:34:31
In reply to Re: Cymbalta/Duloxetine--Something's Up, posted by maximum-doser on August 4, 2004, at 18:30:11
No idea of the cost, but I believe the "standard" dose is 60 mg/day.
Posted by caraher on August 5, 2004, at 12:44:07
In reply to Re: Cymbalta/Duloxetine--Something's Up, posted by maximum-doser on August 4, 2004, at 18:30:11
> Does anyone know what Cymbalta will cost, and what the dosage is?
The Indy Star newspaper reports today that the wholesale price per 60 mg dose will be about $2.85. They also say Lilly expects it will be available in about 80% of pharmacies nationwide by the end of August
Posted by JLM on August 5, 2004, at 12:52:33
In reply to Re: Cymbalta/Duloxetine--Something's Up, posted by caraher on August 5, 2004, at 12:44:07
Something is indeed up.
Cybalta is a drug that was studied in the early nineties by Lilly. Apparently at that time, they didn't think it was of much value as an AD, but it was apparently marked in Europe as a treatment for stress urinary incontinence.
With the failure of, r-fluoxetine, and Proazc going off patent, they HAD to find something to retain their market share, and thus you have Cymbalta...BACK FROM THE DEAD.
Most of the positive studies were open label. The one's where they claimed 'complete remission'.
Don't believe the hype. ESPECIALLY FROM an open label study.
The woman that killed herself was participating in
a 'healthy volunteer' study. I have never heard an explanation from Lilly for her suicide. How does one explain that? Was it the Easter Bunny that made her do it? Space aliens? Hrmmmm........It would be a simple matter to confirm whether it was indeed the drug by doing a challenge/dechallenge,rechallenge protocol, like the one suggested by Healy, but I doubt you are going to see that anytime soon. They promised FDA they would do one for Prozac, but Lilly never carried it out. One wonder's why that is. The "Beasley Protocol"
Posted by caraher on August 5, 2004, at 15:19:40
In reply to Re: Cymbalta/Duloxetine--Something's Up, posted by JLM on August 5, 2004, at 12:52:33
> Cybalta is a drug that was studied in the early nineties by Lilly. Apparently at that time, they didn't think it was of much value as an AD, but it was apparently marked in Europe as a treatment for stress urinary incontinence.The difference as I understand it is that they originally didn't test it at as high a dose as they did this time around.
Of course, this makes the safety concerns all the more poignant, and Lilly probably has not been as publicly responsive to those as they probably should be. I don't think it's possible to "explain" every suicide but Lilly has certainly done far less than they should, especially concerning the tragedy last spring. Pointing out that the subject was no longer taking the study drug and commenting on the low suicide rate among depressed patients who took the duloxetine scarcely reveal an aggressive search for the truth!
Posted by Marilyn on August 6, 2004, at 11:18:15
In reply to Re: Cymbalta/Duloxetine--Something's Up, posted by caraher on August 5, 2004, at 15:19:40
> I don't think it's possible to "explain" every
> suicide but Lilly has certainly done far less
> than they should, especially concerning the
> tragedy last spring. Pointing out that the
> subject was no longer taking the study drug and
> commenting on the low suicide rate among
> depressed patients who took the duloxetine
> scarcely reveal an aggressive search for the
> truth!The truth is indeed what people need. Suicide is not the only side-effect been seen with antidepressants. Actually there are a range of other horrendous side-effects reported by medical physicians. For an example of side-effects to be expected with the ingestion of Cymbalta (duloxetine) I would like to encourage you to read what side-effects are already reported with regards to Effexor (venlafaxine).
http://www.antidepressantsfacts.com/effexor-ADF.htm
Effexor/Efexor Cases & Reviews...
2003
12/00
Case/Review Fatality related to a 30-g venlafaxine overdose
2003
07/12
Case/Review Withdrawal symptoms in Baby after exposure to venlafaxine during pregnancy
2003
07/08
Case/Review Severe Headache with venlafaxine withdrawal
2003
07/00
Case/Review A case report of Paranoid Delusion with venlafaxine use
2003
06/00
Case/Review Mania associated with Effexor discontinuation
2003
05/00
Case/Review Efexor more likely to cause Serotonin Toxicity in patient at risk seizure/suicide
2003
05/00
Case/Review Shock-like Sensations during Venlafaxine Withdrawal
2003
05/00
Case/Review Hepatic Injury & Pancreatitis during treatment with SSRIs & Effexor
2003
04/00
Case/Review Venlafaxine and Increased Aggression in a female with autism
2003
04/00
Case/Review Effexor-induced Pneumonitis (Lung Reaction) & Heart Failure simultaneously
2003
04/00
Case/Review Eroto-Mania induced by venlafaxine: a case study
2003
02/00
Case/Review Serotonin Syndrome Induced by Low-Dose Effexor (venlafaxine)
2002
00/00
Case/Review Venlafaxine -Long Term Adverse Effects
2002
10/00
Case/Review Effexor (& other antidepressants) -induced Sexual Dysfunction
2002
10/04
Case/Review Deaths, Arrhythmias & Seizures in Effexor (venlafaxine) overdose
2002
08/00
Case/Review Venlafaxine Poisoning complicated by a late rise in creatine kinase
2002
07/00
Case/Review Discontinuation/Withdrawal Reactions associated with Effexor (venlafaxine)-5
2002
06/00
Case/Review Delirium during Withdrawal of Effexor
2002
05/00
Case/Review Venlafaxine-associated Vaginal Bleeding
2002
04/00
Case/Review Proconvulsant Effects of high doses of venlafaxine in rats
2002
03/00
Case/Review Hyponatraemia in elderly psychiatric patients treated with SSRIs & Effexor
2002
03/04
Case/Review Serotonin Toxicity with therapeutic doses of dexamphetamine and venlafaxine
2001
00/00
Case/Review An Organic Psychosis due to a venlafaxine-propafenone interaction
2001
08/00
Case/Review Flushing/Return of Hot Flashes in a Menopausal Woman Taking Venlafaxine
2001
07/00
Case/Review Venlafaxine-Induced Hair Loss
2001
07/00
Case/Review Withdrawal Reactions with Effexor (venlafaxine) presenting as stroke
2001
05/00
Case/Review Venlafaxine has a stronger association with Hyponatraemia
2001
01/16
Case/Review Conduction Disturbances Associated with Venlafaxine-overdose
2000
12/00
Case/Review Seizures associated with therapeutic doses of venlafaxine and trimipramine
2000
09/00
Case/Review Reduced Testosterone Level in a venlafaxine treated patient
2000
04/00
Case/Review Abstract: SSRIs & Sexual Dysfunction (Paxil, Zoloft, Effexor)
2000
04/00
Case/Review Venlafaxine-induced Painful Ejaculation
2000
04/00
Case/Review Venlafaxine-induced Serotonin Syndrome with relapse following amitriptyline
2000
03/00
Case/Review Discontinuation/Withdrawal Reactions associated with Effexor (venlafaxine)-4
2000
03/07
Case/Review Venlaxafine-Associated Hepatitis
2000
01/00
Case/Review Effexor: Eosinophilic Pneumonia (Lung/Blood Disease) & Respiratory Failure
2000
01/22
Case/Review Neuroleptic Malignant Syndrome after venlafaxine
1999
00/00
Case/Review Acute Ischaemic Event associated with the use of venlafaxine
1999
10/00
Case/Review Effexor-induced Bruxism (Teeth Grinding)
1999
08/00
Case/Review Influence of CYP2D6 liver-enzymes & Cardiovascular Toxicity of venlafaxine
1999
06/01
Case/Review Venlaxafine-Associated Hepatitis
1999
05/00
Case/Review Venlafaxine can cause Significant Cardiovascular & Neurological Toxicity
1999
04/00
Case/Review Effect of CYP2D6*10 genotype on venlafaxine in healthy adult volunteers
1998
09/00
Case/Review Serotonin Syndrome due to venlafaxine overdose
1998
09/19
Case/Review Discontinuation/Withdrawal Reactions associated with Effexor (venlafaxine)-3
1998
07/00
Case/Review Serotonin Syndrome induced by transitioning from phenelzine to venlafaxine
1998
07/08
Case/Review Serotonin Syndrome with Effexor and other SSRI-antidepressants
1998
04/00
Case/Review Serotonin Syndrome induced by venlafaxine and fluoxetine
1998
04/00
Case/Review Discontinuation/Withdrawal Reactions associated with Effexor (venlafaxine)-2
1998
04/01
Case/Review Hallucinations as a Side Effect of "Venlafaxine"(Effexor) Related Link
1998
03/04
Case/Review Increased Ocular Pressure in 2 patients treated with venlafaxine
1998
02/00
Case/Review Akathisia in withdrawal reactions Effexor (venlafaxine)
1998
01/00
Case/Review Hyponatremia with venlafaxine
1997
12/00
Case/Review Discontinuation/Withdrawal Reactions associated with Effexor (venlafaxine)
1997
12/21
Moore/Study Hard to Swallow: Serzone and Effexor
1997
11/00
Case/Review Seizures, Tachycardia & Rhabdomyolysis following Venlafaxine & Lamotrigine
1997
08/00
Case/Review Venlafaxine produces Sleep Disturbances & Abnormal Leg Movements
1997
06/00
Case/Review Syndrome of Inappropriate ADH Secretion (SIADH) attributed to venlafaxine
1997
02/00
Case/Review Seizure resulting from a venlafaxine overdose
1997
01/00
Case/Review Serotonin Syndrome following a single dose of Effexor (venlafaxine)
1996
07/12
Case/Review Isolated venlafaxine-overdose-induced Serotonin Syndrome
1996
07/08
Case/Review Two Fatal Cases of Venlafaxine Poisoning
1995
00/00
Case/Review A case report of venlafaxine-overdose Toxicity
Posted by SLS on August 6, 2004, at 12:17:00
In reply to Side-effects to be expected from Cymbalta/duloxeti, posted by Marilyn on August 6, 2004, at 11:18:15
> The truth is indeed what people need.
What exactly is this truth?
- Scott
Posted by Leo the Lion on August 7, 2004, at 16:25:32
In reply to Side-effects to be expected from Cymbalta/duloxeti, posted by Marilyn on August 6, 2004, at 11:18:15
The truth is indeed what people need, and they won't get it from so called antidepressantfacs.com
I don't know the intentions of the people running that site, but if they are not bad, they should be sterilized for the better good of humanity.
EX:
Case/Review Fatality related to a 30-g venlafaxine overdose30 grammes, that's 400 pills.
Take xxx aspirin - death
Drink 400 glasses of water within the hour - death
A case review is exactly that; a case review.
from http://www.antidepressantsfacts.com/pinealstory.htm
"...What actually happens when you increase serotonergic neuronal activity or elevate your serotonin levels is this: the stress hormones "Cortisol" & "Adrenaline" (Epinephrine) in the brain and body are triggered by increased serotonergic activity or elevated serotonin levels. ... They give the human personality a boost, producing a euphoric state, which can last for a prolonged period of time. In this manner SSRI-AntiDepressants initially produce the deceptive results the doctor and "patient" are both expecting. *"
I can tell you first hand that you do not get a "boost" from antidepressant.
A very heavy release of adrenalin can get you a boost. A heck load of cortisol make you feel wired in the most unpleasant sense of the word.
So, marilyn, drop dead.
'nuff said
Posted by Marilyn on August 7, 2004, at 18:28:01
In reply to Re: Side-effects to be expected from Cymbalta/duloxeti » Marilyn, posted by Leo the Lion on August 7, 2004, at 16:25:32
> So, marilyn, drop dead.
Well, we all have to die sometime, but until that time arrives I will continue to provide the truth to people who are unbeknown of the powerful physical and mental side-effects of these antidepressants.
I came accross another recent post regarding physical and mental side-effects due to another Lilly SSRI antidepressant known as Prozac (fluoxetine). You can find it at: http://forum.conductdisorders.com/ubbcgi/ultimatebb.cgi?ubb=get_topic&f=1&t=055041
Just another example of the side-effects to be expected with the new Lilly drug Cymbalta (duloxetine)
posted August 07, 2004 12:30
My personal experience withdrawing from Prozac. I felt like I was coming out of my skin, would feel like needles were shooting out of my fingertips,would have awful nightmares, shake out of control, felt sick to my stomach, it was without a doubt the worse thing I ever lived through, and it was at that time that I thought back to my daughter's withdrawal on zoloft, and it made me feel so bad for her and relieved she made it through it. I dont know many people(actually none)who have lived through this nightmare to even remotely share the experience of how it felt, so I feel I should share this here, just as general information/food for thought. My family all knew I was coming off the drug and was alert to my mouthyness, aggitation,all the physical symtoms, and it was living hell. I missed work until I could function.I tapered extremely slowly, right down to breaking open the capsules and putting the powder in something else so I could try and prevent withdrawals. I could feel episodes coming on. I would feel extremely sick, the shakes and the buzzing would start and I had to sit down for at least 30 minutes to ride it. I had a awful time. I am still on trazedone(which also interacted with the prozac)for sleep leftover from my own anxiety from my daughter. This drug is what I now feel is the reason for my excessive sweating! I googled sweat and trazedone and ended up reading a lot about some ADs having excessive sweating as a side effect. I am in the process of coming off of this drug now, as it isnt needed and am not seeing any of the nasty withdrawals I had on Prozac. I find the more I read, and lots of the fine print on how these drugs actually work in the brain/body help understand better. Makes you feel like a home grown scientist.Good luck.
Posted by SLS on August 7, 2004, at 20:26:18
In reply to Re: So, marilyn, drop dead, posted by Marilyn on August 7, 2004, at 18:28:01
> > So, marilyn, drop dead.
> Well, we all have to die sometime, but until that time arrives I will continue to provide the truth to people who are unbeknown of the powerful physical and mental side-effects of these antidepressants.Dear Marilyn,
I'm glad you were able to shrug off so easily the ingracious comments of the previous poster. I don't want you to drop dead. :-)
I still don't understand what your point is. These drugs have side effects. This is not news.
Is there anything else that you are trying to say beyond the fact that these drugs have side effects?
Thanks.
- Scott
Posted by Dr. Bob on August 8, 2004, at 2:32:21
In reply to Re: Side-effects to be expected from Cymbalta/duloxeti » Marilyn, posted by Leo the Lion on August 7, 2004, at 16:25:32
> The truth is indeed what people need, and they won't get it from so called antidepressantfacs.com
>
> they should be sterilized for the better good of humanity.
>
> Take xxx aspirin - death
>
> So, marilyn, drop dead.Please don't discuss specific ways of harming oneself, suggest that others be harmed, exaggerate or overgeneralize, or post under more than one name at the same time.
Sharing something about your own issues and their possible role in your reaction might be an interesting exercise -- and might help others respond to you supportively.
Anyone who has questions about this or about posting policies in general, or who is interested in alternative ways of expressing themselves, should see the FAQ:
http://www.dr-bob.org/babble/faq.html#civil
Also, follow-ups regarding these issues should be redirected to Psycho-Babble Administration.
Thanks,
Bob
Posted by caraher on August 12, 2004, at 11:27:31
In reply to Side-effects to be expected from Cymbalta/duloxeti, posted by Marilyn on August 6, 2004, at 11:18:15
Today's Indy Star had an article saying the FDA will agree with Lilly concerning the suicide in a Cymbalta trial earlier this year: http://www.indystar.com/articles/9/169521-6899-223.html
I was astounded that the "wean" period was only 4 days. I've never quit any antidepressant that abruptly myself and would be rather worried about doing so. Today the a coordinator for the study I'm in told me the suicide occurred 2 weeks after she last took duloxetine. Also, the new consent form I received today says that over 11,000 people have now taken the drug in trials.
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