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Re: Best serotonin 5-HT2C antagonist?

Posted by linkadge on September 10, 2021, at 16:54:14

In reply to Best serotonin 5-HT2C antagonist?, posted by undopaminergic on September 10, 2021, at 12:07:42

Clomipramine, to some degree is a 5-ht2c antagonist. Many of the TCAs are 5-ht2a/c antagonists.

There are no available selective 5-ht2c antagonists. The closest is agomelatine, but I don't think this is available in the US.

Others would include TCAs, mirtazapine, cyproheptadine and atypical antipsychotics.

I sometimes combine mirtazapine and cyproheptadine. I believe that mirtazapine is an inverse agonist which confers some additional properties over traditional antagonists.

A selective 5-ht2c antagonist would be quite useful (in my opinion).

Linkadge


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