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Re: Neuroleptic weight gain dose dependend? Linearly?

Posted by Christ_empowered on January 7, 2021, at 11:40:18

In reply to Re: Neuroleptic weight gain dose dependend? Linearly?, posted by undopaminergic on January 7, 2021, at 5:49:34

just...jumping in here...

i thought -maybe- a D2 partial agonist could be your 1 neuroleptic. I don't know about the newer ones, but Abilify is surprisingly high potency...once you hit the fda-approved max of 30mgs/daily, over 90% of D2 receptors are "occupied" or whatever the experts call it. The only reason people don't twitch and feel horrible like with Haldol or Prolixin is because of the D2 partial agonism, it seems.

that is all. no one is suggesting there is a wonder drug out there, or a pill for every ill. the other potential (possible) upside of a D2 partial agonist is that, at least with Abilify, animal studies show less D2 upregulation, following long term administration. so...assuming that's at all true of human consumption, there -might- possibly be less risk of tardive syndromes, especially tardive psychosis.

i wish you well. my -personal suggestion- would be to try to get down to 1 tranquilizer. in addition to the increase in overall neuroleptic exposure one gets from 2+ at once, some data suggests more risks, overall.




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