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Re: Currently on low dose Nortriptyline but not sure.. undopaminergic

Posted by Skeletor on November 9, 2020, at 12:46:25

In reply to Re: Currently on low dose Nortriptyline but not sure.., posted by undopaminergic on November 9, 2020, at 12:29:42

> > (I've been thinking about trying Aripiprazole ("Abilify"), in case Nortriptyline won't work)
> >
> Probably the only reason aripiprazole sometimes works for depression is that it acts primarily as a dopamine direct agonist at low doses. I strongly recommend you try pramipexole instead, because it acts as an agonist at all doses.
> Indeed, pramipexole is the only drug I ever tried that was (temporarily) effective against anhedonia.
> -undopaminergic

Pramipexole sure is interesting, but difficult to come by... most doctors especially in Germany are afraid of full dopamine agonists ^^

Imho Aripiprazole is interesting because it is pro-dopaminergic at low dosages (2 mg) and it exhibits 5HT2-antagonist-properties AND it isn't a strong antihistamine. But yeah, your mileage may vary.

Low dosage of Olanzapine is also interesting, but strong antihistamine... ^^

What is your current regimen?




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