Psycho-Babble Medication | about biological treatments | Framed
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Re: The other abilifys

Posted by SLS on October 20, 2020, at 7:18:00

In reply to The other abilifys, posted by Christ_empowered on September 17, 2020, at 19:33:16

> Any point in trying? 20mgs abilify seems to be where I land. 15 is ok with some trips into chipper, anxious, and talkative realms.
> I think something about the d2 partial agonists is...better, for a lot of people who require a full dose tranquilizer. Not so interested in the other atypicals.
> Thanks.

On paper, Abilify/aripiprazole is more of an antidepressant than Rixulti/brexpiprazole based upon the higher ratio of DA D3/D2 partial agonism. This seems to be born out clinically from my observation of others.

Vraylar/cariprazine is also a DA D3/D2 partial agonist. I had high hopes as I waited for this drug to be approved. Unfortunately, it made my depression quite a bit worse after 3 days. I refused to continue taking cariprazine because its half-life is so enormously long. It would have taken weeks to leave my system. That's too long to be curled up on the couch whimpering as I did with moclobemide. It was a torturous two weeks. Regarding DA selectivity, cariprazine has a higher D3/D2 ratio than aripiprazole.

I don't have a clinical impression of cariprazine. I haven't seen enough people taking it.

One comment on aripiprazole: Lower dosages 2-5 mg/day are better for depression while higher dosages 20 mg/day are better for schizoid psychoses. I can't characterize middle dosages 10-15 mg/day with any confidence but they might be sufficiently effective in bipolar mania. Higher dosages might actually be counterproductive for treating unipolar depression, if for no other reason than to minimize side-effects.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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