Psycho-Babble Medication | about biological treatments | Framed
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Re: Any ideas why SSRIs give me a 1 day boost

Posted by porkpiehat on July 21, 2020, at 15:43:26

In reply to Re: Any ideas why SSRIs give me a 1 day boost, posted by rjlockhart37 on June 24, 2020, at 0:01:28

My understanding is that the re-uptake action begins pretty much right away, and that is why you feel something quickly: The transporters ARE being blocked and your synapses ARE being flooded with serotonin.

However, the anti-depression/anxiety effect is believed to come from the eventually DOWN-REGULATION of 5ht receptors from the bombardment of extra serotonin (in a complicated set of steps I can't assume to understand).

I experience the same phenomenon. And it is a very specific serotonergic reaction so I don't believe it's completely placebo.

Perhaps one of the higher level guys on the board can shed more light.




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