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Re: Question

Posted by undopaminergic on March 2, 2020, at 13:00:08

In reply to Re: Question, posted by Jadde on March 2, 2020, at 10:46:53

> If I were to quickly cross taper Nardil to Marplan, will I still experience all the withdrawals coming off of Nardil? Or will the Marplan, being an MAOI, cancel those out?

Cross-titration will keep the MAO inhibition in effect; as the MAOI effects from phenelzine (Nardil) diminish, the MAOI effects from isocarboxazid (Marplan) will increase, keeping up the effect, and so, there will be no withdrawal with respect to MAO inhibition.

However, Nardil has a GABAergic metabolite that Marplan lacks, and you may experience some withrawal from that as you phase out Nardil. If you go slow, you should be all right.





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