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Re: Nardil to Marplan SLS

Posted by Jadde on February 27, 2020, at 7:26:55

In reply to Re: Nardil to Marplan, posted by SLS on February 27, 2020, at 0:19:27


>
> Hi, Jade.
>
> I can't speak on behalf of your doctor or your tortured brain, and while I can't guarantee that you would react badly to introducing Marplan while you are still taking Nardil, I would still urge caution and patience - just in case. I once became incoherent for two days and was hospitalized when I waited only 3 days between my last dose of Nardil and my first dose of Parnate. I think this reaction was a form of serotonin syndrome. No other explanations were offered.
>
> My guess is that going from Nardil to Parnate is more dangerous than going from Parnate to Nardil. Parnate has a 3 hour half life. Nardil has a 12 hour half life after a single dose, but it actually inhibits its own metabolism when given chronically. It probably takes longer for MAO activity to recover with Nardil, but I haven't seen anything written about this.
>
> If your doctor or his colleagues have already performed cross-titration successfully with these drugs, then perhaps there is nothing to worry about. Have you searched the Internet regarding this issue? My pharmacy should have Marplan waiting for me tomorrow. I took my last dose of Effexor about a week ago.
>
> Wishing us both good luck!!!
>
>
> - Scott

Hey Scott,

Based on your advice, and these charts, I think I will go with caution and patience.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919171/table/t3/?report=objectonly

https://www.nps.org.au/assets/Products/Guidelines-switching-antidepressants_A3.pdf

So taper off Nardil, 14 day wait, then start Marplan. Im just not in a place where I can take chances.

Funny thing happened when I dcd Nardil, I had a day or two of euphoria. Strange drugs.

Thanks for the advice, may we both have a successful journey with Marplan! Looking forward to hearing about your experience with it :)

Jade



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