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Re: Nardil to Marplan

Posted by SLS on February 27, 2020, at 0:19:27

In reply to Nardil to Marplan, posted by Jadde on February 26, 2020, at 16:40:57

> Saw my pdoc today. After discontinuing Nardil due to surgery I have not been able to recapture its charm. Maybe 25/30%. So disappointing as Nardil gave me 3 years of feeling satisfied with life. Anyway, as a result of all the side effects With Nardil (mainly weight gain) I decided to cross taper from Nardil to Marplan. My doc said outright that it is a weaker A/D, but I decided a full response to Marplan might be better than a partial response to Nardil. Well see.
> As for sleep, he agreed to trying Seroquel but wants me to stay on Olanzapine until the taper is complete.
> Jade

Hi, Jade.

I can't speak on behalf of your doctor or your tortured brain, and while I can't guarantee that you would react badly to introducing Marplan while you are still taking Nardil, I would still urge caution and patience - just in case. I once became incoherent for two days and was hospitalized when I waited only 3 days between my last dose of Nardil and my first dose of Parnate. I think this reaction was a form of serotonin syndrome. No other explanations were offered.

My guess is that going from Nardil to Parnate is more dangerous than going from Parnate to Nardil. Parnate has a 3 hour half life. Nardil has a 12 hour half life after a single dose, but it actually inhibits its own metabolism when given chronically. It probably takes longer for MAO activity to recover with Nardil, but I haven't seen anything written about this.

If your doctor or his colleagues have already performed cross-titration successfully with these drugs, then perhaps there is nothing to worry about. Have you searched the Internet regarding this issue? My pharmacy should have Marplan waiting for me tomorrow. I took my last dose of Effexor about a week ago.

Wishing us both good luck!!!

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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