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Re: Marplan compared to Parnate. Which one?

Posted by PeterMartin on February 20, 2020, at 2:32:59

In reply to Re: Marplan compared to Parnate. Which one? Tom2228, posted by SLS on February 20, 2020, at 1:03:10

> I hope I can convince my doctor to go that high if needed. I emailed him the 2007 Marplan company drug monograph that recommends a maximum dosage of 60 mg/day - as compared to the old recommendation of 30 mg/day.

Actually one thing I noticed when Validus reintroduced Marplan this time is that the included patient guide (the one on their site) lists a maximum dose of 80mg. It's only in this section but it is there on the official pdf on (

Clinical Efficacy Data
The effectiveness of Marplan was demonstrated in two 6-week placebo-controlled studies
conducted in adult outpatients with depressive symptoms that corresponded to the DSM-IV
category of major depressive disorder. The patients often also had signs and symptoms of
anxiety (anxious mood, panic, and/or phobic symptoms). Patients were initiated with a dose
of 10 mg bid, with increases every 2 to 4 days, as tolerated, until a therapeutic effect was
achieved, up to a maximum dose of 80 mg/day. Doses were administered on a divided
schedule ranging from 2 to 4 times a day. The mean dose overall for both studies was
approximately 40 mg/day, with very few patients receiving doses greater than 60 mg/day. In
both studies at the end of 6 weeks, patients receiving Marplan had significantly greater
reduction in signs and symptoms of depression evaluated by the Hamilton Depression Scale,
for both the Total Score and the Depressed Mood Score, than patients who received placebo.

Btw Ive avoided chiming in on this discussion since I've been dealing w RLS issues that I'm pretty sure are related to Nardil cessation. My mood overall has been good (about 5wks on Maplan) but for almost a week I could barely sleep. I know that's not Marplan related, but it has prevented me from feeling "good". The RLS has been less the last two days a and today I finally feel like the restlessness may have abated.

Being on Ritalin w/ Nardil may have complicated the switch (lots of dopamine which seems to be related to rls). I also don't think the Ritalin is helping me - probably making me worse - I'm definitely less productive and don't -feel- much of an effect anymore. I emailed my doc today that I'd like to take a break from Ritalin (asked to go back to armodafinil to hopefully prevent w/d).

Anyway I only posted cause I thought the 80mg note would be helpful (not to talk about this other stuff). But since I did post and it's known that I'm on Marplan just wanted to mention I can't give a fair assessment yet. I do think it's helping and maybe a good amount but I need to get beyond this restless leg stuff (and off the hourly up/down of ir Ritalin) before I'd be comfortable recommending it (based on this trial / worked amazing for me years back).

Sorry if this has run on sentences or typos - typing on my phone about to crash.

As of today:
Marplan 40mg (Started Jan 9 w/ import ver for a week / one month on new US batch)
Lamotrigine 250mg (Unichem batch verified by Valisure)
Metformin IR 1500mg (Mylan batch verified by Valisure)
Ritalin IR 60mg (Not going to refill / asked to switch to Armodafinil-Nuvigil again 250mg)
Seroquel ~20mg Lupin for sleep




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