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Re: Marplan compared to Parnate. Which one? Jadde

Posted by SLS on February 18, 2020, at 14:25:50

In reply to Re: Marplan compared to Parnate. Which one? SLS, posted by Jadde on February 17, 2020, at 11:57:02

Hi, Jade.

> > I have to choose between Marplan and Parnate next week. Any and all comments are welcome.
> >
> > :-)
> >
> > For me, Parnate increases mental energy - which is nice. However it lacks the ability to treat anhedonia and amotivation. It also doesn't improve clarity of thought, cognitive blunting, and memory impairments. I feel flat and don't want to do anything. Parnate is a dead end for me, and I don't want to live out my years that way.
> >
> > I guess this is my main question:
> >
> > Is there anyone who has taken both Marplan and Parnate who had a better response to Marplan?
> >
> > Thanks.
> >
> >
> > - Scott
>
> https://www.google.com/search?q=marplan+verses+parnate&rlz=1CDGOYI_enUS735US735&oq=marplan+verses+parnate&aqs=chrome..69i57.9260j0j7&hl=en-US&sourceid=chrome-mobile&ie=UTF-8
>
> Good luck!
>
> Jade


This was a great find, Jade! Thanks.

Since the 1960s, Marplan has always been described as being a "weak" Nardil. That's why I was never drawn to it. My case is rated as "very severe" on depression rating scales (37) and is all but intractable. I turn 60 tomorrow, and thoughts of committing suicide now intrude my mind often. It seems inevitable.

Here is the passage that I found most compelling:

"Marplan (isocarboxazid). Marplan, like Parnate, comes in 10 mg pills, and is dosed pretty much identically. Marplan was withdrawn from the U.S. market in 1994 for unclear reasons, apparently due primarily to the economics of marketing it. But it was reapproved by the FDA under new ownership (Roche Pharmaceuticals) and with a new, more generous maximum approved dose of 60 mg/day (vs. the former 30 mg/day). The scoop on Marplan is that it is better tolerated than Nardil, and a large metaanalysis reported that it has outperformed placebo more robustly than Parnate or Nardil (Thase et. al., Neuropsychopharmacology 1995;12:185-219)."

Years ago, Thase was one of the foremost researchers for mood illness.

Thanks again. I think I'll send the article to my doctor.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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