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Re: Marplan compared to Parnate. Which one? Lamdage22

Posted by undopaminergic on February 18, 2020, at 10:56:14

In reply to Re: Marplan compared to Parnate. Which one?, posted by Lamdage22 on February 17, 2020, at 13:39:38

> Hmmm, Isn't Marplan Parnate minus the activating metabolite?

My current understanding, is that there is no such metabolite, but rather, the tranylcypromine (Parnate) itself has an intrinsic amphetamine-like action. That would seem to be the main reason why higher doses, beyond what is enough for complete MAO inhibition, is due to that intrinsic stimulant effect.

Selegiline, on the other hand, has amphetamine metabolites.

> How can MAO Inhibition lead to a different outcome, just because it is achieved by a different substance?

The answer, as I see it, is that the only difference lies in what *other* effects a MAOI has. For isocarboxazid (Marplan) there are no known "other" effects beyond the MAOI inhibition, whereas phenelzine (Nardil), tranylcypromine, and selegiline, all have additional effects.

> ... You probably need a main "lifter" so that supplements even make sense. I get that.

I'm not sure what you are saying. Why do supplements make sense?





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