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Re: Can Marplan work better than Nardil or Parnate?

Posted by undopaminergic on January 26, 2020, at 7:24:22

In reply to Can Marplan work better than Nardil or Parnate?, posted by SLS on January 25, 2020, at 12:09:15

You probably know these things, but anyway, isocarboxazid (Marplan) is in part unique compared to the other MAOI alternatives. It a) does not have the GABAergic metabolites of phenelzine (Nardil), b) does not have the intrinsic amphetaminergic action of tranylcypromine (Parnate), c) does not have the l-amphetamine metabolites of selegiline, and d) does not have a preference for MAO-B like selegiline and rasagiline.

The only MAOIs I took were selegiline and rasagiline in low, MAO-B selective doses, but I would love to try tranylcypromine or isocarboxazide, in order of preference.

Also, remember that you can augment the MAOIs if they are not sufficient on their own. I used phenylethylamine (PEA) with selegiline, and while it was a very potent combination, the short half-life of PEA led to constant ups and downs, and I experienced neurotoxicity similar to what long-term meth users do. I would recommend methylphenidate or dextroamphetamine in preference to PEA, but the latter does have the advantage of not requiring a prescription. You can also try augmentation with amino acids, especially phenylalanine, tyrosine, and L-dopa, but if you need more serotonin you can also use tryptophan or 5-hydroxytryptophan (5-HTP).





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