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Re: I knew spicy foods helped my depression

Posted by undopaminergic on January 17, 2020, at 16:51:09

In reply to Re: I knew spicy foods helped my depression undopaminergic, posted by linkadge on January 17, 2020, at 16:07:18

> No clue.
>
> I do know that my medical cannabis has seemed quite a bit more potent in the days that I have ramped up my hot-spice intake.
>
> I am interested in the TRPV1 receptors as they seem to modulate some of the effect of classic antidepressants. They also appear to have anticonvulsant effects.
>
> 3 substances that seem to help me (cannabis, capsaicin and niacin) all interact with TRPV1.
>

As a result of one of my current research projects into prospective augmentation treatments, namely lithium in this case, I came to look into whether lithium was also a TRPV1 (Transient Receptor Potential Vanilloid 1) modulator. There was little or no evidence of this. However, another thing I looked into was how lithium may interact with the cannabinoid system; see:
https://www.ncbi.nlm.nih.gov/pubmed/?term=lithium%5Bti%5D+AND+cannabinoid%5Bti%5D

It appears from a cursory glance (without getting into any details) that lithium and cannabinoids may antagonise certain of each other's effects. Does this make any sense from your experience? You said you are going on and off lithium recurrently.

Maybe you have to choose "either or"?

-undopaminergic


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