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Re: TO UNDOPAMINERGIC linkadge

Posted by undopaminergic on January 11, 2020, at 9:58:26

In reply to Re: TO UNDOPAMINERGIC undopaminergic, posted by linkadge on January 11, 2020, at 8:02:48

> >I've reviewed the literature on modafinil before, >and I just haven't come across any sources >suggesting serotonergic actions of modafinil, >probably because it is a marginal phenomenon.
>
> Neither you nor I know the extent of the effect. The fact is that it DOES have documented (perhaps indirect) effects on the serotoninergic system. The mechanism of modafinil is complex and might (speculation here) affect serotonin via a histaminergic mechanism.
>

Adrafinil, of which modafinil is the active metabolite, was so called because it was thought to be an agonist at alpha1-adrenoceptors. My hunch is that there are downstream effects of this, such as functional (not necessarily directly related to changed concentrations) modulation of several neurotransmitter systems, which may well include serotonin and histamine, and not unlikely dopamine, the latter of which may work synergistically with the dopamine reuptake inhibition activity of the drug. There is some evidence that there is a central system that uses adrenaline (epinephrine) as the neurotransmitter, and this using alpha1B (and maybe beta2 and beta3), in particular, as its preferential target receptors.

This report focusses on a central adrenaline-activated system:
https://www.nature.com/articles/1300222.pdf?origin=ppub

-undopaminergic


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