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Re: Dextromethorphan/Bupropion for MDD soon..... undopaminergic

Posted by pedr on January 10, 2020, at 12:23:01

In reply to Re: Dextromethorphan/Bupropion for MDD soon..... pedr, posted by undopaminergic on January 10, 2020, at 11:03:50

> > Would tablets be worth a shot do you think?
> Yes, absolutely.
> I had an antidepressive response to a dextromethorphan (DXM) pill once. I figured it might be the serotonergic action, because the effect came so soon(*) and the dose was so low.
> (*) the NMDA-antagonism comes largely from metabolism to dextrorphan; hence it takes some time till the onset.
> DXM also binds to sigma-receptors. I'm not sure whether it is an agonist or antagonist.
> -undopaminergic

thanks for the rapid response! so you didn't encounter any nausea?
Cheers, Pete

TRD, TR OCD since 1996.
Meds: 40 Fetzima, 30 Lexapro, 30 Ritalin, 60 Adderall, 2.5 Abilify, 45 Buspar (OCD/GAD), 300 Lyrica, 150 Trazodone (sleep), 40 Percocet (Chronic Pain)
Ad hoc: 2 Ativan




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