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Re: Dextromethorphan/Bupropion for MDD soon..... pedr

Posted by undopaminergic on January 10, 2020, at 11:03:50

In reply to Re: Dextromethorphan/Bupropion for MDD soon..... PeterMartin, posted by pedr on January 10, 2020, at 9:31:01

> Would tablets be worth a shot do you think?

Yes, absolutely.

I had an antidepressive response to a dextromethorphan (DXM) pill once. I figured it might be the serotonergic action, because the effect came so soon(*) and the dose was so low.

(*) the NMDA-antagonism comes largely from metabolism to dextrorphan; hence it takes some time till the onset.

DXM also binds to sigma-receptors. I'm not sure whether it is an agonist or antagonist.





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