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Re: To SLS - clorgyline and imidazoline linkadge

Posted by undopaminergic on January 4, 2020, at 8:08:41

In reply to Re: To SLS - clorgyline and imidazoline undopaminergic, posted by linkadge on January 3, 2020, at 17:29:02

> >This pattern of "helps my depression -- BUT alas X" >seems to be a recurrent theme in your >experimentation. In contrast to my not unusual >pattern of "BUT it stopped working", yours seems to >be "BUT had X adverse effect". I don't recall ever >having to stop an effective antidepressant >treatment for reasons of adverse effects.
> Look, ...

Hey, no need to get defensive, I'm not criticising you. In the part you cited, I was just sharing some observations. I thought I was making an interesting comparison. I concede that it may seem I was implying that you were stopping effective treatments too readily, but that was not the intention. If it was a Freudian slip, it was probably due to envy of your response rate to different agents that have failed to help me.

> So, for example...
> Trimipramine. Yes it worked. However, it is also one of the genotoxic TCAs. I'm sorry, but I need a medication that I can take long term! I don't want to just get settled on a medication that I just get to respond to and then find out that it could give me cancer 20 years down the road. Sorry - deal breaker!

No need to apologise. Thank you for explaining -- I can understand it technically, but I cannot really relate, although I *am* somewhat concerned about the implications of the fact that lamotrigine (another drug I'm taking) accumulates in the iris. Meanwhile, I'm not the least bit worried about getting cancer from trimipramine, even if I were to use it in the long term. I quit smoking, not to avoid lung cancer but to save money. I'm not afraid of death, and moreover, I do not *want* to live a long time, if life isn't better than this. Note that I'm describing my perspective, and not implying that you are more interested in quantity than quality of life. However, I wonder if you have weighed the cancer risk from trimipramine against the risk associated with untreated (or poorly treated) depression. You have said you have suicidal episodes. One of my suicidal acts would have been lethal if I hadn't received treatment as soon as I did, and I was even closer to permanent kidney failure.

> However, again, I don't want to give all the gory details because I don't want to negatively influence other people's response to a medication.

This cuts both ways. I am more prone to nocebo than placebo. If I think something will work great, then it almost certainly won't work at all.

However, I *am* more likely to *try* treatments that people say encouraging things about.

> But if you demand the details then the example I have of trimipramine is one.

Right. It was useful. In any case, your reasons are yours, and as with the example above, I probably would not share your perspective in any case. On the other hand it is interesting to see how others think different.





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