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Re: To SLS - clorgyline and imidazoline

Posted by linkadge on January 3, 2020, at 8:05:11

In reply to Re: To SLS - clorgyline and imidazoline linkadge, posted by SLS on January 2, 2020, at 21:20:54

>What do you know about the function of these >receptors?

It doesn't appear to be a well characterized receptor (at least at the moment). There are two subtypes IM1 & IM2 but not sure of the difference. There is a binding side for imidazoline on MAO enzymes and agonizing the receptors may have some impact on monoamine oxidase levels. It also appears to regulate the alpha-2 receptors (behaving as a functional agonist) as imidazoline agonists can lower blood pressure in a clonidine sensitive manner. Imidazoline agonists may also have anti-addictive / anti-tolerance effects.

Imidazoline agonists may have antidepressant effects, but it's not conclusive as there is a lack of selective agonists for the receptor. The beta carbolines (in coffee) appear to be imidazoline agonists and MAO inhibitors.

Anyhow, not entirely sure, but there is enough evidence that imidazoline regulate certain neurotransmitter systems.

I just thought it was interesting that clorgyline was such a strong agonist at these receptors (which distinguishes it from other MAOIs) and that perhaps this could account for differences in responses to this drug.





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