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Re: Dextromethorphan/Bupropion for MDD soon..... PeterMartin

Posted by undopaminergic on December 17, 2019, at 11:06:25

In reply to Re: Dextromethorphan/Bupropion for MDD soon....., posted by PeterMartin on December 17, 2019, at 3:05:50

> Dextromethorphan works the NMDA receptor so it's novel in that regard. There are other drugs (new) in trial that work by touching on NMDA.

Dextromethorphan (DXM) is also a serotonin reuptake inhibitor. I noticed this myself. It is probably a sigma-receptor agonist too, but I'm not 100% sure about that.

It does work on NMDA. So does memantine, which was so "good" it made me manic. I was having so much fun just from YouTube. Alas, I got impulsive and took an overdose of a few grams, so I'm probably the world record-holder in the category of highest dose of memantine taken.

I'm not sure whether I was trying to kill myself... I guess I was a bit confused.





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