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Question interpreting 2 new studies (Dementia)

Posted by PeterMartin on December 9, 2019, at 21:01:29

Today a new study that found inflammatory marker sCD14 correlates w/ risk of dementia:

I did a search to see if any of my medicines have been studied in regards to sCD14. One random study from 2018 found: Finally, KDM individuals on metformin treatment exhibited significantly lower levels of sCD14, sCD163 and CRP compared with those on non‐metformin‐containing regimens. ( at:

I guess I'm curious (even though it's a stretch) is there a chance Metformin could be good at reducing risk for Dementia?

Here's the info from the new article on the biomarker:
An inflammatory marker called sCD14 is related to brain atrophy, cognitive decline and dementia, according to a study of more than 4,700 participants from two large community-based heart studies. The study was published Monday, Dec. 9, in the journal Neurology.

"We have strong reason to believe that sCD14 can be a useful biomarker to assess a person's risk of cognitive decline and dementia," said study senior author Sudha Seshadri, M.D., professor of neurology at UT Health San Antonio and director of the university's Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases.

"The most exciting part is that we could assess this risk in advance, when there is ample time to intervene and change the course of a person's life," Dr. Seshadri said.

"Higher levels of sCD14 were associated with markers of brain aging and injury, such as total brain atrophy and a decline in executive functioningthe decision-making needed for many activities of daily life," said study lead author Matthew Pase, Ph.D., of the Florey Institute for Neuroscience and Mental Health in Melbourne, Australia.




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