Posted by phidippus on July 28, 2014, at 16:47:03
In reply to Re: ongoing akathisia » g_g_g_unit, posted by SLS on July 28, 2014, at 8:48:33
Although akathisia is commonly attributed to antipsychotic medication and considered as an extrapyramidal symptom, the reports in the literature suggest varying underlying pathways. Deficiency of dopamine in the nigrostriatal pathway is considered to be responsible for extrapyramidal symptoms; however, serotonergic-induced inhibition of dopamine in the mesocorticolimbic pathway projecting from the ventral tegmental area (VTA) of the brain to the prefrontal cortex is thought to be responsible for the arising of akathisia. Like serotonin, norepinephrine acts similarly to inhibit dopamine in the VTA. Consequently, drugs that increase the stimulation of serotonergic or noradrenergic receptors in the mesocorticolimbic pathway theoretically could be responsible for inducing akathisia.
Eric
poster:phidippus
thread:1068586
URL: http://www.dr-bob.org/babble/20140717/msgs/1068910.html