Posted by Tomatheus on February 20, 2014, at 0:10:09
In reply to Nardil/phenelzine at 45mg (Lotsa Questions, Sorry), posted by dbbs on February 19, 2014, at 12:43:09
dbbs,
Hello, and welcome to Psycho-Babble. Thank you for writing all that you did and for posing all of the questions that you posed. My ability to concentrate on reading is only so-so at present (and is better right now than it was earlier today), so I read through your message in parts, and I think that I understand some of the things that you're trying to ask. I don't have answers to all of your questions, but I'll try to address those that I can at least partially answer.
As to whether or not 45 mg of Nardil could have an effect on you therapeutically in the long run, yes, I do think it's possible, but I think that your chances of benefiting from the medication would be stronger at a higher dose. I looked through some of the Nardil-related studies that I have in my possession, and even though none of them have been published recently, I did come across one that found 90 mg of phenelzine to be superior to 45 mg of the medication. Here's a link to the article's abstract:
http://www.ncbi.nlm.nih.gov/pubmed/6992903
Here's what was reported in the "results" section of the article concerning the dose of phenelzine that was used in relation to therapeutic efficacy:
"Patients taking the high dosage of phenelzine (90 mg daily) showed significantly greater improvement on the Hamilton ratings than those taking lower dosage (45 mg/day) (P <0.02) (Table III). A similar result was found with the results of the patients' self-ratings. Differences in improvement between the dosage schedules started to show after two weeks (i.e. after only one week's treatment with the higher dose) and increased in the succeeding weeks of treatment (Figure) although these differences did not reach statistical significance (F = 1.35, df 3 and 174)."
Concerning whether or not Nardil might help with your ADHD, I think it's conceivable that it might, given its effects on dopamine and phenylethylamine (which you mentioned), but I'm not aware of any scientific evidence that would specifically support the notion that Nardil might be an effective ADHD treatment. I think that it would be best to see how Nardil will affect you in the longer run and then to discuss augmentation strategies with your nurse practitioner if the Nardil doesn't seem to help. Unfortunately, I'm not too well versed on what medications (including stimulants and other ADHD medications) can be safely combined with Nardil, both others here on this board might be.
Well, I'm sorry if I couldn't be of more help, but I figured that I'd chime in and try to answer at least a little bit of what you've asked. I do hope that your Nardil trial will continue to work out well. Feel free to let me know if there's anything more that you'd like for me to explain.
Tomatheus
Has an affective psychosis with strong symptoms of fatigue, hypersomnia, and difficulty concentrating
Taking Abilify & supplements
poster:Tomatheus
thread:1060862
URL: http://www.dr-bob.org/babble/20140214/msgs/1060895.html