Posted by F_minor on June 1, 2013, at 4:10:12
In reply to Re: Amitriptyline, Perphenazine and Effexor XR » F_minor, posted by ed_uk2010 on May 30, 2013, at 18:22:30
> >I am taking for years amitriptyline 25mg and Perphenazine 4 mg.
>
> Are these meds helping at all? Amitriptyline is an antidepressant but perphenzine is an antipsychotic. Perphenazine is normally only recommended for long-term use in schizophrenia. For depression and anxiety, it is only recommended for short-term use. This is because long-term use can eventually cause a movement disorder called tardive dyskinesia, even when used at low doses. Tardive dyskinesia usually causes uncontrolled movements of the tongue/mouth/face but can affect other parts of the body too. Hopefully, you might be able to reduce perphenazine gradually and stop.
>
> Tardive dyskinesia...
>
> http://www.youtube.com/watch?v=W_3bbpFjI68
>
> Rather than trying a different antidepressant, you could consider increasing amitriptyline. Most patients need more than 25mg to help their depression.
>
> >What about serotonin syndrome?
>
> Serotonin syndrome is very unlikely with this combination.
>
> I assume you've already tried one or more SSRI antidepressants such as citalopram or sertraline? Although Effexor can be effective, it tends to cause more side effects than SSRIs and more severe withdrawal symptoms when it's stopped. For this reason it is not a drug of first choice. Among the SSRIs, sertraline might be a good choice because it can be combined with your current meds without an interaction. Some SSRIs interact with amitriptyline and so would not be suitable.
>
>
>Thank you all for your responses!
I am on day 2 of effexor 75mg. I have tried escitalopram for some years and fluoxetine... i see on drug interactions that sertraline increases plasma concentrations of phenothiazines,like perphenazine... so i am not taking the risk.
Perphenazine helps keep me calm from my phobias, amitriptyline i dont know.
i had a very expensive psychiatrist, who was considered very good, and gave me fluoxetine with amitriptyline, 40mg of fluoxetine and 50mg of amitriptyline... when i told him to check for interactions he said i was stupid....
Anyway, i cant up the dose of amitriptyline cause here in Greece it is sold as a combo with perphenazine and i dont want to take more of the antipsychotic.
poster:F_minor
thread:1044497
URL: http://www.dr-bob.org/babble/20130527/msgs/1044591.html