Posted by Tomatheus on August 16, 2010, at 19:58:39
In reply to Moclobemide issues - very short half-life » Tomatheus, posted by ed_uk2010 on August 16, 2010, at 15:50:14
> You make some excellent points. Now about moclobemide... I've been wondering whether the problem with moclobemide is not its reversibility, but its very short duration of action. It has an extremely short half life and I suspect that it does not consistently inhibit MAO-A across day, despite twice a day dosing. On average, moclobemide's half-life is about 3 hours. In some patients, it is as little as 2 hours. For a *reversible* inhibitor of MAO, how can this be adequate?
>
> I wonder whether moclobemide would be more effective if given more frequently? 150mg four times a day might work.Ed,
You could be right about moclobemide's efficacy problem having to do with its short half-life. I'm pretty sure that I tried taking it three times a day at one point, but I'm not sure if I ever went up to 150 mg four times daily. I agree that such a dose might increase the medication's effectiveness.
Tomatheus
poster:Tomatheus
thread:958646
URL: http://www.dr-bob.org/babble/20100811/msgs/958874.html