Posted by ed_uk2010 on August 15, 2010, at 12:08:20
In reply to Re: NARDIL / PARNATE Users Please Read » ed_uk2010, posted by angels78 on August 15, 2010, at 0:09:40
>He said he was correct regarding the 1/14th rate
I assume he is a pharmacologist? :) If so, perhaps he has performed a study which demonstrates that switching from one MAOI to another without any washout period is safe? (since this is what he is advising you to do).
>(MAO replacement, after stopping phenelzine) is a constant, continuous process.
Perhaps he could provide a reference? What makes him think that the process of MAO replacement occurs at a constant rate? The synthesis of enzymes/proteins in the body is a controlled process. I doubt that MAO synthesis occurs at a constant rate no matter what. The brain does not function like a mechanical toy. For many enzymes, the rate of synthesis of new enzymes is controlled by the concentration of substances which are metabolised by the enzyme, or by the concentration of the end product produced by the enzyme.
>it is nothing short of obvious that in any given 24-hour period, you can expect a turnover of roughly 1/14th of total MAO enzymes.
Not necessarily.
To be honest Angel, I am having difficulty understanding why this person is advising you to go against standard medical advice. The recommendation seems to be based mainly on his own personal experience, n=1.
In order for something to be considered safe, it needs to be tested in a large number of people. One person's reaction is not sufficient. Not everyone suffers an adverse reaction, clearly, but that fact that some people have suffered serious reactions does suggest that abruptly switching from Nardil to Parnate is not a good idea.
Be safe.
poster:ed_uk2010
thread:958545
URL: http://www.dr-bob.org/babble/20100811/msgs/958675.html