Posted by SLS on September 30, 2009, at 14:50:58
In reply to How does Abilify augment antidepressants?, posted by number42 on September 30, 2009, at 12:00:32
> I recently added Abilify 20 mgs. to 80 mgs. of Prozac and i am doing so much better. Anyone familiar with how an anti-psychotic enhances an AD?
With Abilify, there are probably at least three mechanisms involved:
1. Dopamine D2 and D3 receptor partial agonism.
2. Serotonin 5-HT2a receptor antagonism.
3. Serotonin 5-HT1a receptor partial agonism.
The net effect here is to increase dopamine and serotonin activity.
Linkadge could probably add some insight into what are the downstream effects of these events.
- Scott
poster:SLS
thread:919132
URL: http://www.dr-bob.org/babble/20090921/msgs/919148.html