Posted by Helena24 on September 26, 2009, at 11:38:33
In reply to Agomelatine/Valdoxan for anxiety??, posted by jms600 on September 21, 2009, at 6:38:51
"Take less of the tianeptine" is not so easy since it is a habit-forming drug.
Look at my thread about tianeptine addiction.http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20090921/msgs/918569.html#918569
Tianeptine raises dopamine in the nucleus accumbens.
Agomelatine raises DA and NE in the prefrontal cortex.
I was hoping to "augment" the tianeptine with the agomelatine /to "boost" it's effects.Agomelatine is also similar to mirtrazapine in some ways (5ht-receptor antagonism/increase of dopamine and norepinephrine in the prefrontal cortex).
In the past I had a bad reaction to mirtrazapine (the 2nd time I tried it) with agitation/dispair and emotional outburts.I took it with no other drug.
Perhaps I'm sensitive to this specific action of increased DA and NE in the PFC and/or 5ht2b/c receptor antagonism.
Maybe I try Ago again when I manage to come off the tianeptine.
In my oppinion tianeptine is much more effective than agomelatine.
Servier failed to draw the appropriate attention to it.
poster:Helena24
thread:917917
URL: http://www.dr-bob.org/babble/20090921/msgs/918571.html