Posted by doxogenic boy on September 24, 2009, at 14:28:15
In reply to Re: Who Is Peter Breggin? » 49er, posted by metafunj on September 23, 2009, at 21:21:06
> I am taking Wellbutrin and have tinnitus. I hope it lessens or in the case that the med doesn't work, I hope it goes away when I discontinue.Some antidepressants are tried against tinnitus. Maybe it works to add nortriptyline?
http://www.ncbi.nlm.nih.gov/pubmed/8215728
Arch Intern Med. 1993 Oct 11;153(19):2251-9.
[...]
A randomized trial of nortriptyline for severe chronic tinnitus. Effects on depression, disability, and tinnitus symptoms.
Sullivan M, Katon W, Russo J, Dobie R, Sakai C.Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle.
OBJECTIVE: To determine whether the antidepressant, nortriptyline, is effective for treatment of depression, tinnitus-related disability, and tinnitus symptoms in patients with severe chronic tinnitus. DESIGN: A 12-week, double-blind, randomized controlled trial. SETTING: A university otolaryngology clinic. PATIENTS: Ninety-two subjects with severe chronic tinnitus: 38 with current major depression and 54 with depressive symptoms and significant tinnitus-related disability. INTERVENTION: Nortriptyline (maintained at 50 to 150 mg/mL for 6 weeks) or placebo. MAIN OUTCOME MEASURES: Hamilton Depression Rating Scale, Tinnitus Disability Measures, and Audiometric Measures. RESULTS: Nortriptyline was superior to placebo by multivariate analysis of covariance for depression (10.6 vs 14.3 final Hamilton Depression score), for tinnitus-related disability (1.8 vs 2.4 final MPI Tinnitus Interference), and tinnitus loudness (13.6 vs 20.0 dB final loudness match [in worst ear at tinnitus frequency]). When major depression and depressive symptoms groups were considered separately, nortriptyline was superior to placebo on these same measures but differences did not achieve statistical significance. CONCLUSIONS: The antidepressant nortriptyline decreases depression, functional disability, and tinnitus loudness associated with severe chronic tinnitus. What appears to be irreversible disability of otologic origin may, in part, be reversible disability of psychiatric origin.
------------------------doxogenic
poster:doxogenic boy
thread:917824
URL: http://www.dr-bob.org/babble/20090921/msgs/918323.html