Posted by zatar on August 17, 2009, at 10:40:40
In reply to To Scott - Things Ivan Goldberg Has Tried, posted by bulldog2 on August 10, 2009, at 11:10:37
The thing that comes to mind is that most drug studies didn't, and still don't, take into account the differences in drug metabolism of patients. Slow metabolizers and fast metabolizers, not to mention the effect that other medications have, are all lumped together. Then there's the differences in receptor sensitivity.
I used low dose doxepin (10mg) for sleep for years and it worked like a charm, yet a blood level at that dose was "zero". Lately, the same 10mg didn't keep me asleep, so I raised the dose to 40mg to get the same effect. Admittedly these are low doses and most docs wouldn't even think twice about it, but my point is that some may need MORE than typical doses to see an effect, while some may need LESS.
-zatar
poster:zatar
thread:911309
URL: http://www.dr-bob.org/babble/20090810/msgs/912575.html