Re: Linkadge. to late in the evening to

Posted by linkadge on January 6, 2007, at 20:59:15

In reply to Linkadge. to late in the evening to, posted by fca on January 6, 2007, at 18:39:15

>I know this is an unfair tactic but I need to >move on.
No worries.

>but I know for a fact that almost 1/3 of persons >with schizophrenia who never responded to any >treatment now have a realistic chance of >improving.
I am not saying that antipsychotics may not produce some impressive short term changes in behavior in schizophrenics, but that is far from proof of helping them long term.
>If you wish, start researching the PET studies >done before and after serious periods of >decompensation.
We could also look at post mortem neuroleptic induced morphological alterations in brain structure.
>Or better yet go back and look
>at the mortality and morbidity statistics for >people with schizophrenia who were alive 50-70 >years ago before any of the major antipsychotics.
I was under the impression that antipsychotics increased morbidity. If you are referring to suicide risk, clozapine is the only antipsychotic with any proven effect on suicide rate.

>I would guess that most were dead by their mid >fifties and/or had such overwhelming cognitive >limitations that they were essentially unable to >function.
There are many studies that show that *long term* neuroleptic use worsens cogntative function in schizophrenia.
Time Dependent Cognitive Deficits Associated with First and Second Generation Antipsychotics: Cholinergic Dysregulation as a Potential Mechanism
http://jpet.aspetjournals.org/cgi/content/abstract/jpet.106.106047v2
Evidence of neuroleptic induced brain dammage:
http://www.namiscc.org/Research/2003/NeurolepticInducedBrainDamage.htm
Dramatic downregulation of BDNF following Haldol treatment.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11071712&dopt=Abstract
The Effect of Antipsychotics on Cognition in Schizophrenia
http://www.cnsforum.com/magazine/focus/cognition_schizophrenia/
"Neuroleptics were associated with the reduction of psychotic symptoms of schizophrenia, but they did not demonstrate any significant impact on cognitive features of the disease (Sweeney et al., 1991)."
"Conventional antipsychotics, which primarily block D2 dopamine receptors, may demonstrate no effect (Berman et al., 1986) or minimal beneficial effect on cognitive functioning (Serper et al., 1994) or can even further impair cognitive functioning (Sweeney et al., 1991). Also, traditional antipsychotics cause extrapyramidal symptoms (EPS), which significantly decrease speed on cognitive tasks involving motor output and readiness to respond."
"Acute treatment with typical neuroleptics can result in a deterioration in some aspects of attention and motor behavior"
"neuroleptic drugs lack the ability to improve the various domains of cognitive function impaired in schizophrenia."
>People with schizophrenia still have a much
>shorter life span than others but I bet it sure
>is longer than before.

http://www.john-libbey-eurotext.fr/en/revues/bio_rech/jpc/e-docs/00/02/71/38/resume.md?type=text.html
"However, it is possible that the impact of adverse effects on the cardiovascular system related to certain antipsychotic drug use may well increase the prevalence of mortality and morbidity due to cardiovascular events and may also play a significant role in the reduced life expectancy of the patient with schizophrenia"
Linkadge

Thread

Patient paid to accept neuroleptic depot injection ed_uk 1/5/07
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Re: Patient paid to accept neuroleptic depot injec fca 1/6/07
Re: Patient paid to accept neuroleptic depot injec » ed_uk SLS 1/6/07
Re: Patient paid to accept neuroleptic depot injec SLS 1/6/07
Re: Patient paid to accept neuroleptic depot injec linkadge 1/6/07
Re: Patient paid to accept neuroleptic depot injec med_empowered 1/6/07
Re: Patient paid to accept neuroleptic depot injec linkadge 1/6/07
Re: Patient paid to accept neuroleptic depot injec linkadge 1/6/07
Linkadge. to late in the evening to fca 1/6/07
Re: Patient paid to accept neuroleptic depot injec » linkadge Phillipa 1/6/07
Re: the case for neuroleptics is kind of weak » med_empowered Phillipa 1/6/07
Re: Patient paid to accept neuroleptic depot injec » SLS ed_uk 1/6/07
Re: Patient paid to accept neuroleptic depot injec » laima Phillipa 1/6/07
Re: Linkadge. to late in the evening to linkadge 1/6/07
Re: the case for neuroleptics is kind of weak linkadge 1/6/07
Re: the case for neuroleptics is kind of weak linkadge 1/6/07
Re: Patient paid to accept neuroleptic depot injec » Phillipa laima 1/6/07
Re: Patient paid to accept neuroleptic depot injec » Phillipa laima 1/6/07
Re: Patient paid to accept neuroleptic depot injec » laima Phillipa 1/6/07
Re: Patient paid to accept neuroleptic depot injec » laima Phillipa 1/6/07
Re: Patient paid to accept neuroleptic depot injec » laima Quintal 1/6/07
Re: Patient paid to accept neuroleptic depot injec » linkadge yxibow 1/6/07
Re: Patient paid to accept neuroleptic depot injec » Phillipa laima 1/6/07
Re: Patient paid to accept neuroleptic depot injec » Quintal laima 1/6/07
Re: Patient paid to accept neuroleptic depot injec » Phillipa laima 1/6/07
Re: Patient paid to accept neuroleptic depot injec » Quintal yxibow 1/6/07
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Re: samples... PS laima 1/12/07

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