Posted by Quintal on January 5, 2007, at 10:58:21
In reply to Re: Triple Re-uptake inhibitors- why so excited?, posted by linkadge on January 4, 2007, at 16:59:44
>Just like how MDMA, is a serotonin reuptake inhibitor, but that doesn't mean SSRI's have
the abuse potential that MDMA has.Well it seems MDMA is a bit more than an SSRI:
__________________________________________________MDMA (3,4-methylenedioxy-N-methylamphetamine), most commonly known by the street names Ecstasy, E, X, or XTC is a semisynthetic entactogen of the phenethylamine family, whose primary effect is believed to be the stimulation of secretion as well as inhibition of re-uptake of large amounts of serotonin as well as dopamine and norepinephrine in the brain, inducing a general sense of openness, empathy, energy, euphoria, and well-being.
http://en.wikipedia.org/wiki/MDMA
__________________________________________________
>Another point is that SJW is a triple uptake inhibitor, with moderate but equal potency on the three monoamines. SJW has no abuse potential though, and is not comparable to cocaineSounds a bit like Nardil:
__________________________________________________Some believe that Hyperforin is the major constituent responsible for antidepressant activity, and it has been shown to inhibit the uptake of 5-HT, dopamine, noradrenaline, GABA and glutamate.
http://en.wikipedia.org/wiki/St_John%27s_Wort
__________________________________________________I've never taken Nardil but I know I was able to abuse Parnate as a euphoric stimulant at high doses.
I'm sure abuse potential will be carefully screened in the clinical trials but that wasn't really the point I was trying to make. It just seems we're taking a step closer to the pharmacology of many substances of abuse in our quest for more effective antidepressants, regardless of whether these substances will have abuse potential themselves.
Ronald K. Siegel, Ph.D. makes this point in his book "Intoxication: the universal drive for mind altering substances"
Q
poster:Quintal
thread:719292
URL: http://www.dr-bob.org/babble/20070101/msgs/719568.html